関: ribosomal frameshifting、translational frameshifting

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2013/09/04 21:31:14」(JST)

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A ribosomal frameshift allows alternative translation of a mRNA sequence by changing the open reading frame. It is commonly found in viruses including barley yellow dwarf virus,^[1] potato leafroll virus^[2] simian retrovirus-1 and coronaviruses.^[3] Ribosomal frameshifting is promoted by a pseudoknot structure and slippery sequence (usually UUUAAAC).^[4] It is often required for translation of putative RNA-dependent RNA polymerase.

References[edit source | edit]

^ Vincent JR, Lister RM, Larkins BA (October 1991). "Nucleotide sequence analysis and genomic organization of the NY-RPV isolate of barley yellow dwarf virus". J. Gen. Virol. 72 (10): 2347–55. PMID 1840612.
^ Kujawa AB, Drugeon G, Hulanicka D, Haenni AL (May 1993). "Structural requirements for efficient translational frameshifting in the synthesis of the putative viral RNA-dependent RNA polymerase of potato leafroll virus". Nucleic Acids Res. 21 (9): 2165–71. doi:10.1093/nar/21.9.2165. PMC 309480. PMID 8502558.
^ Sung D, Kang H (March 1998). "Mutational analysis of the RNA pseudoknot involved in efficient ribosomal frameshifting in simian retrovirus-1". Nucleic Acids Res. 26 (6): 1369–72. doi:10.1093/nar/26.6.1369. PMC 147434. PMID 9490779.
^ Meulenberg JJ, Hulst MM, de Meijer EJ, et al. (January 1993). "Lelystad virus, the causative agent of porcine epidemic abortion and respiratory syndrome (PEARS), is related to LDV and EAV". Virology 192 (1): 62–72. doi:10.1006/viro.1993.1008. PMID 8517032.

External links[edit source | edit]

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English Journal

Interaction of polyamines and mTOR signaling in the synthesis of antizyme (AZ).

Ray RM1, Bavaria M2, Johnson LR2.
Cellular signalling.Cell Signal.2015 Sep;27(9):1850-9. doi: 10.1016/j.cellsig.2015.06.002. Epub 2015 Jun 17.
Tissue polyamine levels are largely determined by the activity of ornithine decarboxylase (ODC, EC 4.1.17), which catalyzes the conversion of ornithine to the diamine putrescine. The activity of the enzyme is primarily regulated by a negative feedback mechanism involving ODC antizyme (AZ). Our previ
PMID 26093026

Cis- and trans-regulation of luteovirus gene expression by the 3' end of the viral genome.

Miller WA1, Jackson J2, Feng Y3.
Virus research.Virus Res.2015 Aug 3;206:37-45. doi: 10.1016/j.virusres.2015.03.009. Epub 2015 Apr 6.
Translation of the 5.7kb luteovirus genome is controlled by the 3' untranslated region (UTR). Base pairing between regions of the 3' UTR and sequences kilobases upstream is required for cap-independent translation and ribosomal frameshifting needed to synthesize the viral replicase. Luteoviruses pro
PMID 25858272

A Nascent Peptide Signal Responsive to Endogenous Levels of Polyamines Acts to Stimulate Regulatory Frameshifting on Antizyme mRNA.

Yordanova MM1, Wu C2, Andreev DE3, Sachs MS2, Atkins JF4.
The Journal of biological chemistry.J Biol Chem.2015 Jul 17;290(29):17863-78. doi: 10.1074/jbc.M115.647065. Epub 2015 May 21.
The protein antizyme is a negative regulator of cellular polyamine concentrations from yeast to mammals. Synthesis of functional antizyme requires programmed +1 ribosomal frameshifting at the 3' end of the first of two partially overlapping ORFs. The frameshift is the sensor and effector in an autor
PMID 25998126

Japanese Journal

Preparation of Functional Single-Chain Antibodies against Bioactive Gibberellins by Utilizing Randomly Mutagenized Phage-Display Libraries

Suzuki Yoshihito,Ito Shinsaku,Otsuka Kaori [他],IWASAWA Eriko,NAKAJIMA Masatoshi,YAMAGUCHI Isomaro
Bioscience, biotechnology, and biochemistry 69(3), 610-619, 2005-03-23
… We found further that a ribosomal frameshift to complement a nonsense mutation frequently occurred in an amber suppressor strain of <I>E. …
NAID 130000030401

Hepatitis C virus quasispecies in cancerous and noncancerous hepatic lesions: the core protein-encoding region.

Alam Shahjalal S.,Nakamura Takashi,Naganuma Atsushi,Nozaki Akito,Nouso Kazuhiro,Shimomura Hiroyuki,Kato Nobuyuki
Acta Medica Okayama 56(3), 2002-06
… Moreover, during the course of the study, we obtained several interesting variants possessing a substitution at codon 9 of the core gene, whose substitution has been shown to induce the production of the F protein synthesized by a - 2/+1 ribosomal frameshift.</p> …
NAID 120002312476

Analysis of micronuclear, macronuclear and cDNA sequences encoding the regulatory subunit of camp-dependent protein kinase of Euplotes octocarinatus : evidence for a ribosomal frameshift

TAN M.
J. Euk. Microbiol. 48, 80-87, 2001
NAID 30015499164

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