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a salt or ester of acetic acid (同)ethanoate

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酢酸(さくさん)塩;アセテート(酢酸人造絹糸)

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/06/26 16:30:17」(JST)

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Retinyl acetate (retinol acetate, vitamin A acetate) is a natural form of vitamin A which is the acetate ester of retinol. It has potential antineoplastic and chemopreventive activities.^[2]^[3]

In the United States, retinyl acetate is classified generally recognized as safe (GRAS) in the amounts used to fortify foods with vitamin A.^[4]^[5]

Teratogenicity

World Health Organization recommendation on Maternal Supplementation During Pregnancy states that "health benefits are expected for the mother and her developing fetus with little risk of detriment to either, from a daily supplement not exceeding 10,000IU [preformed] vitamin A (3000mcg RE) at any time during pregnancy." Preformed Vitamin A refers to retinyl palmitate and retinyl acetate. ^[6]

References

^ ^a ^b ^c Retinyl acetate from Sigma-Aldrich
^ Moon, Richard C.; Grubbs, Clinton J.; Sporn, Michael B.; Goodman, Dawn G. (1977). "Retinyl acetate inhibits mammary carcinogenesis induced by N-methyl-N-nitrosourea". Nature 267 (5612): 620–1. doi:10.1038/267620a0. PMID 876383.
^ Retinyl acetate, National Cancer Institute Drug Dictionary
^ Select Committee on GRAS Substances (SCOGS) Opinion: Vitamin A, United States Food and Drug Administration
^ 21 C.F.R. 184.1930
^ http://whqlibdoc.who.int/hq/1998/WHO_NUT_98.4_eng.pdf

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English Journal

DEVTA: results from the biggest clinical trial ever.

Garner P, Taylor-Robinson D, Sachdev HS.SourceLiverpool School of Tropical Medicine, Liverpool L3 5QA, UK. pgarner@liv.ac.uk
Lancet.Lancet.2013 Apr 27;381(9876):1439-41. doi: 10.1016/S0140-6736(13)60600-5. Epub 2013 Mar 14.
PMID 23498851

Population deworming every 6 months with albendazole in 1 million pre-school children in north India: DEVTA, a cluster-randomised trial.

Awasthi S, Peto R, Read S, Richards SM, Pande V, Bundy D; DEVTA (Deworming and Enhanced Vitamin A) team.Collaborators (74)Ayyar L, Chandra A, Joshi VC, Narang N, Rehman H, Saxena N, Prakash N, Sharma A, Sharma M, Tripathi M, Upreti DK, Das R, Lal A, Rastogi T, Mani SS, Chitransh D, Pandey L, Tandon A, Bajpai D, Chandra U, Dwivedi A, Pant PK, Shukla V, Ahmad A, Ahmad H, Bahadur J, Chandra H, Chandra R, Chaturvedi A, Dwivedi S, Kumar A, Kumar D, Kumar M, Kumar N, Kumar R, Kumar S, Kumar S 1st, Kumar S 2nd, Pal C, Prasad M, Kumar R 1st, Kumar R 2nd, Rashid Z, Singh H, Shukla H, Shukla KB, Shukla SS, Shukla VB, Singh S, Singh S, Verma SS, Verma SS, Chandra R, Haq I, Kazi M, Kumar A, Kumar K, Kumar M, Kumar S, Lal B, Tiwari AK, Awasthi S, Maseeh A, Najeeb S, Neetu L, Parween S, Rai B, Rastogi T, Sharma A, Shukla R, Shukla S, Shukla L, Srivastava A, Srivastava VK.
Lancet.Lancet.2013 Apr 27;381(9876):1478-86. doi: 10.1016/S0140-6736(12)62126-6. Epub 2013 Mar 14.
BACKGROUND: In north India many pre-school children are underweight, many have intestinal worms, and 2-3% die at ages 1·0-6·0 years. We used the state-wide Integrated Child Development Service (ICDS) infrastructure to help to assess any effects of regular deworming on mortality.METHODS: Participan
PMID 23498850

Vitamin A supplementation every 6 months with retinol in 1 million pre-school children in north India: DEVTA, a cluster-randomised trial.

Awasthi S, Peto R, Read S, Clark S, Pande V, Bundy D; DEVTA (Deworming and Enhanced Vitamin A) team.Collaborators (74)Ayyar L, Chandra A, Joshi VC, Narang N, Rehman H, Saxena N, Prakash N, Sharma A, Sharma M, Tripathi M, Upreti DK, Das R, Lal A, Rastogi T, Mani SS, Chitransh D, Pandey L, Tandon A, Bajpai D, Chandra U, Dwivedi A, Pant PK, Shukla V, Ahmad A, Ahmad H, Bahadur J, Chandra H, Chandra R, Chaturvedi A, Dwivedi S, Kumar A, Kumar D, Kumar M, Kumar N, Kumar R, Kumar S, Kumar S 1st, Kumar S 2nd, Pal C, Prasad M, Kumar R 1st, Kumar R 2nd, Rashid Z, Singh H, Shukla H, Shukla KB, Shukla SS, Shukla VB, Singh S, Singh S, Verma SS, Verma SS, Chandra R, Haq I, Kazi M, Kumar A, Kumar K, Kumar M, Kumar S, Lal B, Tiwari AK, Awasthi S, Maseeh A, Najeeb S, Neetu L, Parween S, Rai B, Rastogi T, Sharma A, Shukla R, Shukla S, Shukla L, Srivastava A, Srivastava VK.
Lancet.Lancet.2013 Apr 27;381(9876):1469-77. doi: 10.1016/S0140-6736(12)62125-4. Epub 2013 Mar 14.
BACKGROUND: In north India, vitamin A deficiency (retinol <0·70 μmol/L) is common in pre-school children and 2-3% die at ages 1·0-6·0 years. We aimed to assess whether periodic vitamin A supplementation could reduce this mortality.METHODS: Participants in this cluster-randomised trial were pr
PMID 23498849

Japanese Journal

脂溶性ビタミンおよび関連物質のファージ不活化作用

ビタミン 84(1), 1-6, 2010-01-25
NAID 110007521140

Electrophoretic analysis of various urinary proteins in Japanese patients with Dent disease

Journal of Electrophoresis 54(1), 19-25, 2010
NAID 130000423936

Flow-Injection Determination of Retinol and Tocopherol in Pharmaceuticals with Acidic Potassium Permanganate Chemiluminescence

Analytical Sciences 25(3), 407-412, 2009
NAID 130004441832

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★リンクテーブル★

リンク元	「レチノール」「retinol palmitate」「酢酸レチノール」

「レチノール」

Retinyl acetate
	IUPAC name (2E,4E,6E,8E)-3,7-Dimethyl-9-(2,6,6-trimethylcyclohex-1-en-1-yl)nona-2,4,6,8-tetraen-1-yl acetate
	Other names Retinol acetate; Vitamin A acetate; Vitamin A1 acetate; Acetylretinol; all-trans-Retinol acetate; all-trans-Retinyl acetate; all-trans-Vitamin A acetate;
Identifiers
CAS number	127-47-9
PubChem	638034
ChemSpider	553599
Jmol-3D images	Image 1
	SMILES O=C(OC/C=C(/C=C/C=C(/C=C/C1=C(/CCCC1(C)C)C)C)C)C ;
	InChI InChI=1S/C22H32O2/c1-17(9-7-10-18(2)14-16-24-20(4)23)12-13-21-19(3)11-8-15-22(21,5)6/h7,9-10,12-14H,8,11,15-16H2,1-6H3/b10-7+,13-12+,17-9+,18-14+; Key: QGNJRVVDBSJHIZ-QHLGVNSISA-N InChI=1/C22H32O2/c1-17(9-7-10-18(2)14-16-24-20(4)23)12-13-21-19(3)11-8-15-22(21,5)6/h7,9-10,12-14H,8,11,15-16H2,1-6H3/b10-7+,13-12+,17-9+,18-14+; Key: QGNJRVVDBSJHIZ-QHLGVNSIBE ;
Properties
Molecular formula	C22H32O2
Molar mass	328.49 g mol−1
Melting point	57 to 58 °C (135 to 136 °F; 330 to 331 K)
Hazards
R-phrases	R38-R63
S-phrases	S36/37
NFPA 704	1 1 0
	Except where noted otherwise, data are given for materials in their standard state (at 25 °C (77 °F), 100 kPa)
	Infobox references