- 関
- protein precursor
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2017/03/14 17:28:04」(JST)
[Wiki en表示]
A protein precursor, also called a pro-protein or pro-peptide, is an inactive protein (or peptide) that can be turned into an active form by post-translational modification, such as breaking off a piece of the molecule or adding on another molecule. The name of the precursor for a protein is often prefixed by pro-. Examples include proinsulin and proopiomelanocortin, which are both prohormones.
Protein precursors are often used by an organism when the subsequent protein is potentially harmful, but needs to be available on short notice and/or in large quantities. Enzyme precursors are called zymogens or proenzymes. Examples are enzymes of the digestive tract in humans.
Some protein precursors are secreted from the cell. Many of these are synthesized with an N-terminal signal peptide that targets them for secretion. Like other proteins that contain a signal peptide, their name is prefixed by pre. They are thus called pre-pro-proteins or pre-pro-peptides.[1] The signal peptide is cleaved off in the endoplasmic reticulum.[1] An example is preproinsulin.
Pro-sequences are areas in the protein that are essential for its correct folding, usually in the transition of a protein from an inactive to an active state. Pro-sequences may also be involved in pro-protein
References
- ^ a b Alberts, Bruce (2002). Molecular biology of the cell. New York: Garland Science. p. 760. ISBN 0-8153-3218-1.
English Journal
- Novel translocation intermediate allows re-evaluation of roles of ATP, proton motive force and SecG at the late stage of preprotein translocation.
- Nishiyama KI1,2, Tokuda H3.
- Genes to cells : devoted to molecular & cellular mechanisms.Genes Cells.2016 Dec;21(12):1353-1364. doi: 10.1111/gtc.12447. Epub 2016 Nov 4.
- Presecretory proteins such as pOmpA are translocated across the inner membrane of Escherichia coli by Sec translocase powered by ATP and proton motive force (PMF). Translocation activity has been determined by protease protection assaying in vitro. We identified a new translocation intermediate at
- PMID 27813233
- Plant-Specific Preprotein and Amino Acid Transporter Proteins Are Required for tRNA Import into Mitochondria.
- Murcha MW1,2,3,4,5,6,7, Kubiszewski-Jakubiak S8,9,10,11,12,13,14, Teixeira PF8,9,10,11,12,13,14, Gügel IL8,9,10,11,12,13,14, Kmiec B8,9,10,11,12,13,14, Narsai R8,9,10,11,12,13,14, Ivanova A8,9,10,11,12,13,14, Megel C8,9,10,11,12,13,14, Schock A8,9,10,11,12,13,14, Kraus S8,9,10,11,12,13,14, Berkowitz O8,9,10,11,12,13,14, Glaser E8,9,10,11,12,13,14, Philippar K8,9,10,11,12,13,14, Maréchal-Drouard L8,9,10,11,12,13,14, Soll J8,9,10,11,12,13,14, Whelan J1,2,3,4,5,6,7.
- Plant physiology.Plant Physiol.2016 Dec;172(4):2471-2490. Epub 2016 Oct 27.
- A variety of eukaryotes, in particular plants, do not contain the required number of tRNAs to support the translation of mitochondria-encoded genes and thus need to import tRNAs from the cytosol. This study identified two Arabidopsis (Arabidopsis thaliana) proteins, Tric1 and Tric2 (for tRNA import
- PMID 27789739
- Amyloid β-peptides interfere with mitochondrial preprotein import competence by a coaggregation process.
- Cenini G1, Rüb C1, Bruderek M1, Voos W2.
- Molecular biology of the cell.Mol Biol Cell.2016 Nov 1;27(21):3257-3272. Epub 2016 Sep 14.
- Aβ peptides play a central role in the etiology of Alzheimer disease (AD) by exerting cellular toxicity correlated with aggregate formation. Experimental evidence has shown intraneuronal accumulation of Aβ peptides and interference with mitochondrial functions. Nevertheless, the relevance of intra
- PMID 27630262
Japanese Journal
- In Vitro Fluorescent Analysis of Preprotein Import into Chloroplasts
- Kwanchanok Sattasuk,Inoue Hitoshi,Akita Mitsuru
- Bioscience, biotechnology, and biochemistry 75(10), 2001-2007, 2011-10-23
- Despite recent progress in fluorescence techniques employed to observe protein localization in living cells, the <I>in vitro</I> chloroplastic protein transport assay remains a useful tool …
- NAID 10029873114
- Spatial Orientation of Mitochondrial Processing Peptidase and a Preprotein Revealed by Fluorescence Resonance Energy Transfer
- Nishino Tomonori G.,Kitano Ken,Kojima Katsuhiko [他],OGISHIMA Tadashi,ITO Akio,KITADA Sakae
- The journal of biochemistry 141(6), 889-895, 2007-06-01
- NAID 10020098777
- Characterization of the preprotein and amino acid transporter gene family in Arabidopsis
Related Links
- preprotein [pre-pro´tēn] a protein precursor that contains a signal peptide sequence; it is a nonpolar sequence at the head of the growing polypeptide chain and is required for its transfer into the cistern of the endoplasmic reticulum ...
- Definition of preprotein. Provided by Stedman's medical dictionary and Drugs.com. Includes medical terms and definitions. ... Drugs.com Mobile Apps The easiest way to lookup drug information, identify pills, check interactions and ...
★リンクテーブル★
[★]
- 英
- protein precursor、preprotein
- 関
- 前タンパク質
[★]
- 英
- preprotein
- 関
- タンパク質前駆体
[★]
- 関
- preprotein