WordNet

a salt or ester of maleic acid; used as a nontricyclic antidepressant drug for psychomotor activation
an antihistamine used in preparations to treat allergies and respiratory infections; used to treat rhinitis and skin rashes and pruritus

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2013/07/27 16:25:56」(JST)

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Pheniramine (INN, trade name Avil, among others) is an antihistamine with anticholinergic properties used to treat allergic conditions such as hay fever or urticaria. It has relatively strong sedative effects, and may sometimes be used off-label as an over-the-counter sleeping pill in a similar manner to other sedating antihistamines such as diphenhydramine. Pheniramine is also commonly found in eyedrops used for the treatment of allergic conjunctivitis.

Pheniramine is generally sold in combination with other medications, rather than as a stand-alone drug, although some formulations are available containing pheniramine by itself. As an example, Neo Citran contains pheniramine.

Chemical relatives[edit]

Derivatives of pheniramine include chlorpheniramine, dexchlorpheniramine, dexbrompheniramine, deschlorpheniramine, triprolidine, and brompheniramine. Two other halogenated derivatives, iodopheniramine and fluorpheniramine, are currently in use for research on combination therapies for malaria and some cancers. The halogenation of pheniramine increases its potency by 20-fold.

Availability[edit]

In India, it is not given as an OTC as was done previously as this drug has been misused as a sleeping pill alternative.

Side effects[edit]

Pheniramine may cause drowsiness, bradycardia and over-dosage may lead to sleep disorders. Overdose may lead to seizures, especially in combination with alcohol. People combining with cortisol in the long term should avoid pheniramine as it may cause lowered levels of adrenaline (epinephrine) which may lead to loss of consciousness.

References[edit]

Leaflet on Avil^{[dead link]} by The Royal Australian College of General Practitioners

External links[edit]

MedlinePlus Encyclopedia Pheniramine overdose

This drug article relating to the respiratory system is a stub. You can help Wikipedia by expanding it.

This sedative-related article is a stub. You can help Wikipedia by expanding it.

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1. アレルギー性結膜炎：マネージメント allergic conjunctivitis management
2. 翼状片 pterygium
3. Conjunctivitis
4. 中毒性結膜炎 toxic conjunctivitis
5. 妊娠中絶の概要 overview of pregnancy termination

English Journal

Assessment of protective effects of methylprednisolone and pheniramine maleate on reperfusion injury in kidney after distant organ ischemia: a rat model.

Bayrak S, Yurekli I, Gokalp O, Kiray M, Bademci MS, Ozcem B, Besir Y, Yilik L, Kestelli M, Gurbuz A.SourceDepartment of Cardiovascular Surgery, Izmir Ataturk Education and Research Hospital, Izmir, Turkey.
Annals of vascular surgery.Ann Vasc Surg.2012 May;26(4):559-65. Epub 2012 Mar 22.
BACKGROUND: Ischemia/reperfusion (I/R) injury of tissues is a common problem that cardiovascular surgeons are faced with. Suppression of inflammation, which plays an important role in the pathogenesis of I/R injury, may reduce this damage. The aim of this study is to investigate the protective effec
PMID 22445244

Blood-brain barrier in vitro models as tools in drug discovery: assessment of the transport ranking of antihistaminic drugs.

Neuhaus W, Mandikova J, Pawlowitsch R, Linz B, Bennani-Baiti B, Lauer R, Lachmann B, Noe CR.SourceDepartment of Medicinal Chemistry, University of Vienna, Austria. winfried.neuhaus@univie.ac.at
Die Pharmazie.Pharmazie.2012 May;67(5):432-9.
In the course of our validation program testing blood-brain barrier (BBB) in vitro models for their usability as tools in drug discovery it was evaluated whether an established Transwell model based on porcine cell line PBMEC/C1-2 was able to differentiate between the transport properties of first a
PMID 22764578

「フェニラミン」

Pheniramine
Systematic (IUPAC) name
	N,N-dimethyl-3-phenyl-3-pyridin-2-yl-propan-1-amine
Clinical data
AHFS/Drugs.com	International Drug Names
MedlinePlus	a606008
Pregnancy cat.	A (AU) C (US)
Legal status	?
Routes	Oral ; injection (intramuscular or slow intravenous); topical (ophthalmic/nasal solution)
Pharmacokinetic data
Metabolism	Hepatic hydroxylation, demethylation and glucuronidation
Excretion	Renal
Identifiers
CAS number	86-21-5
ATC code	R06AB05
PubChem	CID 4761
DrugBank	DB01620
ChemSpider	4597
UNII	134FM9ZZ6M
KEGG	D08355
ChEMBL	CHEMBL1193
Chemical data
Formula	C16H20N2
Mol. mass	240.343 g/mol
	SMILES n1ccccc1C(c2ccccc2)CCN(C)C;
	InChI InChI=1S/C16H20N2/c1-18(2)13-11-15(14-8-4-3-5-9-14)16-10-6-7-12-17-16/h3-10,12,15H,11,13H2,1-2H3 ; Key:IJHNSHDBIRRJRN-UHFFFAOYSA-N ;
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　　[★]

英: pheniramine、pheniramine maleate
関: マレイン酸フェニラミン

クロルフェニラミン

抗ヒスタミン薬;アルキルアミン系

「マレイン酸フェニラミン」

　　[★]

英: pheniramine maleate
関: フェニラミン

「chlorpheniramine maleate」

　　[★]

マレイン酸クロルフェニラミン、クロルフェニラミンマレイン酸塩

関: Chlor-Trimeton、chlorphenamine、chlorpheniramine、chlorpheniramine polistirex、d-chlorpheniramine maleate

同: Chlor-Trimeton

「d-chlorpheniramine maleate」

　　[★]

d-マレイン酸クロルフェニラミン、d-クロルフェニラミンマレイン酸塩

関: chlorpheniramine、chlorpheniramine maleate、chlorpheniramine polistirex

「maleate」

　　[★]

マレイン酸、マレイン酸塩、マレイン酸エステル

関: maleic acid

maleic acid

リンク元	「フェニラミン」「マレイン酸フェニラミン」
拡張検索	「chlorpheniramine maleate」「d-chlorpheniramine maleate」
関連記事	「maleate」

匿名

検索

案内

案内

pheniramine maleate