腹膜癒着

WordNet

a fibrous band of scar tissue that binds together normally separate anatomical structures
abnormal union of bodily tissues; most common in the abdomen
of or relating to or affecting the peritoneum; "peritoneal cancer"

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粘着,付着

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1. 成人における術後の腹膜癒着とその予防 postoperative peritoneal adhesions in adults and their prevention
2. 成人における機械的小腸閉塞の疫学、臨床的特徴、および診断 epidemiology clinical features and diagnosis of mechanical small bowel obstruction in adults
3. 成人における機械的小腸閉塞のマネージメントの概要 overview of management of mechanical small bowel obstruction in adults
4. 機械的大腸閉塞の概要 overview of mechanical colorectal obstruction
5. 女性不妊症の原因 causes of female infertility

English Journal

Heated and humidified CO2 pneumoperitoneum inhibits tumour cell proliferation, migration and invasion in colon cancer.

Cai W1, Dong F, Wang Z, Yang X, Zheng M, Che X.Author information 1Department of General Surgery, Ruijin Hospital, School of Medicine, Shanghai Jiaotong University , Shanghai .AbstractAbstract Background: Peritoneal carcinomatosis (PC) arising from colorectal cancer is associated with poor prognosis and few treatment options are currently available. Laparoscopic CO2 insufflation stimulates the progression and metastatic potential of gastrointestinal carcinomas. However, heated and humidified CO2 pneumoperitoneum (HH-CO2) is a promising treatment for PC, although its effects and mechanism of action in human colon cancer cells remain unclear. This study evaluated the anti-tumour effects of HH-CO2 on human colon cancer in vitro. Methods: Cell viability was assessed using the WST-8 assay in two colon cancer cell lines. Apoptosis was assessed by Annexin V PI flow cytometry, and migration and invasion were examined using wound healing and Transwell® invasion assays. The expressions of Bcl-2, Bax, matrix metalloproteinase-2 (MMP-2), E-cadherin, ICAM-1, and CD44 were detected by western blotting. Results: HH-CO2 significantly inhibited cell proliferation, migration, invasion and adhesion. HH-CO2 induced apoptosis and significantly inhibited the expression of Bcl-2, MMP-2, ICAM-1 and CD44, and increased Bax and E-cadherin expression in colon cancer cells. Conclusions: HH-CO2 induces apoptosis and inhibits proliferation, migration, invasion and adhesion of human colon cancer cells. Our results suggest that HH-CO2 may serve as a potential candidate for the treatment and/or prevention of peritoneal carcinomatosis from colorectal cancer and warrant further in vivo investigation.
International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group.Int J Hyperthermia.2014 Apr 10. [Epub ahead of print]
Abstract Background: Peritoneal carcinomatosis (PC) arising from colorectal cancer is associated with poor prognosis and few treatment options are currently available. Laparoscopic CO2 insufflation stimulates the progression and metastatic potential of gastrointestinal carcinomas. However, heated an
PMID 24720439

Malignant ascites in ovarian cancer and the role of targeted therapeutics.

Smolle E1, Taucher V, Haybaeck J.Author information 1Department of Neuropathology, Institute of Pathology, Medical University of Graz, Auenbrugger-Platz 25, A-8036 Graz, Austria. johannes.haybaeck@medunigraz.at.AbstractOvarian cancer (OC) is the eighth most lethal gynecological malignancy and the main cause of gynecological cancer death in industrialized countries. Malignant ascites is often found in OC, with about 10% of patients suffering from recurrent OC. Tumor cells in OC-associated malignant ascites promote disease recurrence and patient mortality is mainly associated with widespread metastasis to serosal surfaces and accompanying peritoneal effusions. Targeted therapies have recently been developed as novel therapeutic options for malignant ascites. The tri-functional anti-epithelial cell adhesion molecule and anti-cluster of differentiation 3 monoclonal antibody catumaxumab has been assessed in the therapy of malignant ascites, and proven to significantly reduce the ascitic flow rate when applied into the peritoneal cavity. The anti-angiogenic targeted agent bevacizumab has also shown good effects in the symptomatic treatment of malignant ascites, significantly prolonging the time until the next paracentesis. Vascular endothelial growth factor (VEGF) Trap, or aflibercept, is a fusion protein that inhibits VEGF-receptor binding. Aflibercept has proven to be effective in reduction of ascites, diminishing clinical symptoms of ascites and prolonging the time to next paracentesis. All three agents we review in the present article are effective in symptomatic control of ascites, leading to a rapid reduction of effusion and prolonging the time interval between paracenteses. However, no improvement in overall survival was observed in any of the clinical trials reported. We, thus, conclude that further investigations on larger patient series are needed to clarify whether the reduction of ascites by these targeted agents leads to a prolongation in tumor-related survival or not.
Anticancer research.Anticancer Res.2014 Apr;34(4):1553-61.
Ovarian cancer (OC) is the eighth most lethal gynecological malignancy and the main cause of gynecological cancer death in industrialized countries. Malignant ascites is often found in OC, with about 10% of patients suffering from recurrent OC. Tumor cells in OC-associated malignant ascites promote
PMID 24692682

Effect of lesion location on endometriotic adhesion and angiogenesis in SCID mice.

Lu Z1, Zhang W, Jiang S, Zou J, Li Y.Author information 1Department of Obstetrics and Gynecology, Chinese PLA General Hospital, Beijing, China.AbstractOBJECTIVE: To evaluate the effects of lesion location on adhesion and angiogenesis of transplanted endometriotic lesions in SCID mice.
Archives of gynecology and obstetrics.Arch Gynecol Obstet.2014 Apr;289(4):823-30. doi: 10.1007/s00404-013-3048-9. Epub 2013 Oct 23.
OBJECTIVE: To evaluate the effects of lesion location on adhesion and angiogenesis of transplanted endometriotic lesions in SCID mice.METHODS: Three groups of female SCID mice included intraperitoneal (i.p.) (n = 12), subcutaneous (s.c.) (n = 12), and mock surgery (control) (n = 12). At 2 wee
PMID 24150520

Japanese Journal

手術手技 TAPPの腹膜縫合部へのセプラフィルムの使用 : 特に5mm portからの挿入について

加藤恭郎,鈴木大聡,垣本佳士 [他]
臨床外科 = Journal of clinical surgery 69(6), 761-764, 2014-06
NAID 40020109189

3) 卵巣癌腹膜播種の分子機構に関する複合的機能解析と新規治療戦略(シンポジウム1:腫瘍「婦人科癌の浸潤・転移機構の解明と臨床応用」,第65回日本産科婦人科学会・学術講演会講演要旨)

柴田清住
日本産科婦人科學會雜誌 65(10), 2414-2425, 2013-10-01
… Unlike other epithelial tumors, peritoneal dissemination is the most common mechanism of disease progression in ovarian cancer. … In this study, we investigated the participation of EMT, cancer stem cell, stem cell niche, and microRNA to peritoneal dissemination. … Methods We first investigated the induction of MMP secretion by interaction between ovarian cancer cells and peritoneal methothelial cells. …
NAID 110009674403

The effects of thermally cross-linked gelatin film on intraperitoneal dissemination of cancer cells : an in vitro study using human gastrointestinal cancer cell lines

MIYAMOTO Hiroe,TSUJIMOTO Hiroyuki,HORII Tsunehito [他],Ikeda Junki,Orikasa Taichi,Takamori Hideki,Torii Hiroko,Ozamoto Yuki,Morita Shinichiro,Urabe Mamoru,Hagiwara Akeo
同志社大学理工学研究報告 54(1), 16-20, 2013-04
… To prevent adhesion formation after abdominal surgery, we newly developed a thermally cross-linked gelatin film and previously reported its superior anti-adhesive effects with excellent peritoneal regeneration. …
NAID 110009575473