関: 6-hydroxydopamine、6-OHDA

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2012/12/05 12:34:39」(JST)

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Oxidopamine, also known as 6-hydroxydopamine (6-OHDA) or 2,4,5-trihydroxyphenethylamine, is a neurotoxic synthetic organic compound used by researchers to selectively destroy dopaminergic and noradrenergic neurons in the brain. 6-OHDA is thought to enter the neurons via the dopamine and noradrenaline (norepinephrine) reuptake transporters. Oxidopamine is often used in conjunction with a selective noradrenaline reuptake inhibitor (such as desipramine) to selectively destroy dopaminergic neurons only.

The main use for oxidopamine in scientific research is to induce Parkinsonism in laboratory animals such as mice, rats and monkeys, in order to develop and test new medicines for treating Parkinson's disease in humans. In order to induce this condition in animals, around 70% of the dopaminergic neurons in the substantia nigra of the brain must be destroyed, and this is achieved either with oxidopamine or MPTP. Both these agents likely destroy neurons by generating reactive oxygen species such as superoxide radical. Oxidopamine toxicity in neonatal rodents is also used as an animal model for the Lesch-Nyhan syndrome.^[1]

References

^ Breese GR, Knapp DJ, Criswell HE, Moy SS, Papadeas ST, Blake BL (2005). "The neonate-6-hydroxydopamine-lesioned rat: a model for clinical neuroscience and neurobiological principles". Brain Res. Brain Res. Rev. 48 (1): 57–73. doi:10.1016/j.brainresrev.2004.08.004. PMID 15708628.

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English Journal

Resistin protects against 6-hydroxydopamine-induced cell death in dopaminergic-like MES23.5 cells.

Lu DY, Chen JH, Tan TW, Huang CY, Yeh WL, Hsu HC.SourceGraduate Institute of Neural and Cognitive Sciences, College of Life Sciences, China Medical University, Taichung, Taiwan. dahyuu@mail.cmu.edu.tw
Journal of cellular physiology.J Cell Physiol.2013 Mar;228(3):563-71. doi: 10.1002/jcp.24163.
Resistin is originally reported as an adipose tissue-specific hormone and is thought to represent a link between obesity and insulin-resistant diabetes. Adipokines exert energy-regulation and has been reported to have neuroprotective effect like leptin, adiponectin, and ghrelin. However, the role of
PMID 22806254

In-vivo measurement of LDOPA uptake, dopamine reserve and turnover in the rat brain using [18F]FDOPA PET.

Walker MD, Dinelle K, Kornelsen R, McCormick S, Mah C, Holden JE, Farrer MJ, Stoessl AJ, Sossi V.SourceDepartment of Physics and Astronomy, University of British Columbia, Vancouver, BC, Canada. mwalker@physics.ubc.ca
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.J Cereb Blood Flow Metab.2013 Jan;33(1):59-66. doi: 10.1038/jcbfm.2012.120. Epub 2012 Aug 29.
Longitudinal measurements of dopamine (DA) uptake and turnover in transgenic rodents may be critical when developing disease-modifying therapies for Parkinson's disease (PD). We demonstrate methodology for such measurements using [(18)F]fluoro-3,4-dihydroxyphenyl-L-alanine ([(18)F]FDOPA) positron em
PMID 22929441

Therapeutic deep brain stimulation in Parkinsonian rats directly influences motor cortex.

Li Q, Ke Y, Chan DC, Qian ZM, Yung KK, Ko H, Arbuthnott GW, Yung WH.SourceSchool of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong, China.
Neuron.Neuron.2012 Dec 6;76(5):1030-41. doi: 10.1016/j.neuron.2012.09.032.
Much recent discussion about the origin of Parkinsonian symptoms has centered around the idea that they arise with the increase of beta frequency waves in the EEG. This activity may be closely related to an oscillation between subthalamic nucleus (STN) and globus pallidus. Since STN is the target of
PMID 23217750

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★リンクテーブル★

リンク元	「6-hydroxydopamine」「6-OHDA」「オキシドパミン」

「6-hydroxydopamine」

Oxidopamine
	IUPAC name 5-(2-Aminoethyl)benzene-1,2,4-triol
Identifiers
CAS number	1199-18-4
PubChem	4624
ChemSpider	4463
UNII	8HW4YBZ748
KEGG	D05294
ChEMBL	CHEMBL337702
Jmol-3D images	Image 1
	SMILES c1c(c(cc(c1O)O)O)CCN ;
	InChI InChI=1S/C8H11NO3/c9-2-1-5-3-7(11)8(12)4-6(5)10/h3-4,10-12H,1-2,9H2 ; Key: DIVDFFZHCJEHGG-UHFFFAOYSA-N InChI=1/C8H11NO3/c9-2-1-5-3-7(11)8(12)4-6(5)10/h3-4,10-12H,1-2,9H2; Key: DIVDFFZHCJEHGG-UHFFFAOYAG ;
Properties
Molecular formula	C8H11NO3
Molar mass	169.18 g/mol
	(verify) (what is: /?); Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
	Infobox references