関: oxiconazole nitrate

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2013/01/29 22:48:53」(JST)

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Oxiconazole nitrate (U.S.: Oxistat, Canada: Oxizole) is an antifungal medication typically administered in a cream or lotion to treat skin infections, such as athlete's foot, jock itch and ringworm. It can also be prescribed to treat the skin rash known as tinea versicolor, caused by systemic yeast overgrowth (Candida spp.).

Mixich, G.; Thiele, K.; 1986, U.S. Patent 4,550,175.

External links

MedlinePlus - Oxiconazole

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1. 紅色陰癬 erythrasma
2. カンジダ性間擦疹 candidal intertrigo

English Journal

AroER tri-screen is a biologically relevant assay for endocrine disrupting chemicals modulating the activity of aromatase and/or the estrogen receptor.

Chen S1, Zhou D, Hsin LY, Kanaya N, Wong C, Yip R, Sakamuru S, Xia M, Yuan YC, Witt K, Teng C.
Toxicological sciences : an official journal of the Society of Toxicology.Toxicol Sci.2014 May;139(1):198-209. doi: 10.1093/toxsci/kfu023. Epub 2014 Feb 4.
Endocrine disrupting chemicals (EDCs) interfere with the biosynthesis, metabolism, and functions of steroid hormones, including estrogens and androgens. Aromatase enzyme converts androgen to estrogen. Thus, EDCs against aromatase significantly impact estrogen- and/or androgen-dependent functions, in
PMID 24496634

Intertrigo and secondary skin infections.

Kalra MG1, Higgins KE2, Kinney BS1.
American family physician.Am Fam Physician.2014 Apr 1;89(7):569-73.
Intertrigo is a superficial inflammatory dermatitis occurring on two closely opposed skin surfaces as a result of moisture, friction, and lack of ventilation. Bodily secretions, including perspiration, urine, and feces, often exacerbate skin inflammation. Physical examination of skin folds reveals r
PMID 24695603

Optimizing topical antifungal therapy for superficial cutaneous fungal infections: focus on topical naftifine for cutaneous dermatophytosis.

Del Rosso JQ, Kircik LH.
Journal of drugs in dermatology : JDD.J Drugs Dermatol.2013 Nov;12(11 Suppl):s165-71.
Superficial cutaneous fungal infections (SCFIs) are commonly encountered in clinical practice in the United States, and comprise infections of the skin by dermatophytes and yeasts. The most common organisms causing SCFI are dermatophytes, especially Trichophyton spp. With the exception of onchomycos
PMID 24196340

Japanese Journal

新規ピリドン系抗真菌剤Rilopiroxのin vitro抗Candida活性の特徴

原田郁子,三井一孝,内田勝久,山口英世
The Japanese Journal of Antibiotics 52(2), 146-152, 1999
… 対照薬には同系の既存薬ciclopirox olamine (CPO), ならびに産婦人科領域における真菌症の局所療法に最も繁用されているイミダゾール系の2薬剤oxiconazole nitrate (OCZ) およびisoconazole nitrate (ICZ) を使用し, 次の成績を得た。 …
NAID 130004395853

新規ピリドン系抗真菌剤 Rilopirox の in vitro 抗真菌活性

原田郁子,三井一孝,内田勝久,山口英世
The Japanese Journal of Antibiotics 50(2), 195-199, 1997
… 新規ピリドン系抗真菌化合物Rilopirox(RIL)のin vitro抗真菌活性を, 既存のピリドン系抗真菌剤Ciclopirox olamine (CPO) およびイミダゾール系抗真菌剤Oxiconazole nitrate (OCZ) を対照薬として測定した。 …
NAID 130004395794

表在性皮膚真菌症に対するオキナゾールクリームの効果:オキナゾール®クリーム治験班

吉川邦彦
皮膚 29(2), 318-325, 1987
… 大阪市内とその近郊の14総合病院において, 80人の表在性皮膚真菌症患者にオキナゾール®クリーム (1% oxiconazole nitrate 含有) を用い, その臨床的効果を調べた。 …
NAID 130003843474

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リンク元	「オキシコナゾール」
拡張検索	「oxiconazole nitrate」

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Oxiconazole
Systematic (IUPAC) name
	(E)-[1-(2,4-dichlorophenyl)-2-(1H-imidazol-1-yl)ethylidene][(2,4-dichlorophenyl)methoxy]amine
Clinical data
Trade names	Oxistat
AHFS/Drugs.com	monograph
MedlinePlus	a689004
Pregnancy cat.	?
Legal status	?
Identifiers
CAS number	64211-46-7
ATC code	D01AC11 G01AF17
PubChem	CID 5361463
DrugBank	DB00239
ChemSpider	4514745
UNII	RQ8UL4C17S
KEGG	D00885
ChEMBL	CHEMBL1262
Chemical data
Formula	C18H13Cl4N3O
Mol. mass	429.126 g/mol
	SMILES Clc3ccc(/C(=N\OCc1ccc(Cl)cc1Cl)Cn2ccnc2)c(Cl)c3;
	InChI InChI=1S/C18H13Cl4N3O/c19-13-2-1-12(16(21)7-13)10-26-24-18(9-25-6-5-23-11-25)15-4-3-14(20)8-17(15)22/h1-8,11H,9-10H2/b24-18- ; Key:QRJJEGAJXVEBNE-MOHJPFBDSA-N ;
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