関: para-aortic body

WordNet

wind instrument whose sound is produced by means of pipes arranged in sets supplied with air from a bellows and controlled from a large complex musical keyboard (同)pipe_organ
a fully differentiated structural and functional unit in an animal that is specialized for some particular function
a government agency or instrument devoted to the performance of some specific function; "The Census Bureau is an organ of the Commerce Department"
a periodical that is published by a special interest group; "the organ of the communist party"

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『オルガン』,パイプオルガン(pipe organ),リードオルガン(reed organ),電子オルガン(electronic organ),手回しオルガン(barrel organ) / (動植物の)『器官』 / (政党・会社などの)機関誌,機関紙 / 《しばしば複数形で》(行動・実施などの)組織,機関
《所有・所属》…『の』,…のものである,…に属する・《材料・要素》…『でできた』,から成る・《部分》…『の』[『中の』] ・《数量・単位・種類を表す名詞に付いて》…の・《原因・動機》…『で』,のために(because of) ・《主格関係》…『の』,による,によって・《目的格関係》…『を』,の・《同格関係》…『という』・《関係・関連》…『についての』[『の』],の点で・《抽象名詞などと共に》…の[性質をもつ] ・《『It is』+『形』+『of』+『名』+『to』 doの形で,ofの後の名詞を意味上の主語として》・《分離》…『から』・《起原・出所》…『から』[『の』](out of) ・《『名』+『of』+『a』(『an』)+『名』の形で》…のような・《『名』+『of』+『mine』(『yours, his』など独立所有格)の形で》…の…・《時》(1)《副詞句を作って》…に《形容詞句を作って》…の・《時刻》《米》…前(to,《米》before)
OLD French古[代]フランス語

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/10/09 09:10:34」(JST)

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The organ of Zuckerkandl is a chromaffin body derived from neural crest located at the bifurcation of the aorta or at the origin of the inferior mesenteric artery. It can be the source of pheochromocytoma or paraganglioma.^[1]

The term para-aortic body is also sometimes used to describe it, as it usually arises near the abdominal aorta, but this term can be the source of confusion, because the term "corpora paraaortica" is also used to describe the aortic body, which arises near the thoracic aorta. This diffuse group of neuroendocrine sympathetic fibres was first described by Emil Zuckerkandl, a professor of anatomy at the University of Vienna, in 1901.^[2]

Some sources equate the "aortic bodies" and "paraaortic bodies",^[3] while other sources explicitly distinguish between the two.^[4]^[5] When a distinction is made, the "aortic bodies" are chemoreceptors which regulate circulation, while the "paraaortic bodies" are the chromaffin cells which manufacture catecholamines.

Structure

Function

Its physiological role is thought to be of greatest importance during the early gestational period as a homeostatic regulator of blood pressure, secreting catecholamines into the fetal circulation.

The organ itself regresses in the late third trimester and following birth to form the aorticosympathetic group of the adult paraganglia.

Clinical significance

Pathology

It can be the source of paraganglioma or pheochromocytoma.^[6]

The organ of Zuckerkandl is of pathological significance in the adult as a common extra-adrenal site of pheochromocytoma though the most common extra-adrenal site is in the superior para-aortic region between the diaphragm and lower renal poles.^[7]

Extra-adrenal tumors account for around 10% of all cases of pheochromocytoma.^[8] Resection has been described.^[9]

In addition to its endocrine effects, it can also cause obstructive pathology.^[10]

References

^ Dossett, Lesly; Rudzinski, Erin; Blevins, Lewis; Chambers, Eugene (2007). "Malignant Pheochromocytoma of the Organ of Zuckerkandl Requiring Aortic and Vena Caval Reconstruction". Endocrine Practice 13 (5): 493–7. doi:10.4158/ep.13.5.493. PMID 17872352.
^ synd/3111 at Who Named It?
^ "organs of Zuckerkandl" at Dorland's Medical Dictionary
^ Aortic Bodies at the US National Library of Medicine Medical Subject Headings (MeSH)
^ Para-Aortic Bodies at the US National Library of Medicine Medical Subject Headings (MeSH)
^ Saurborn, Daniel P.; Kruskal, Jonathan B.; Stillman, Isaac E.; Parangi, Sareh (2003). "Best Cases from the AFIP". RadioGraphics 23 (5): 1279–86. doi:10.1148/rg.235035022. PMID 12975514.
^ Whalen, R. K.; Althausen, A. F.; Daniels, G. H. (1992). "Extra-adrenal pheochromocytoma". The Journal of urology 147 (1): 1–10. PMID 1729490.
^ Thompson, Robert W. (2002). "Detection and Management of Small Aortic Aneurysms". New England Journal of Medicine 346 (19): 1484–6. doi:10.1056/NEJM200205093461910. PMID 12000820.
^ Kravarusic, Dragan; Pinto-Rojas, Alfredo; Al-Assiri, Ali; Sigalet, David (2007). "Laparoscopic resection of extra-adrenal pheochromocytoma—Case report and review of the literature in pediatric patients". Journal of Pediatric Surgery 42 (10): 1780–4. doi:10.1016/j.jpedsurg.2007.06.025. PMID 17923216.
^ Blecha, Matthew; Galanopolous, Christos; Dharkar, Dilip; Salti, George (2005). "Massive Organ of Zuckerkandl Inducing Small Bowel Obstruction". Journal of the American College of Surgeons 201 (3): 480–1. doi:10.1016/j.jamcollsurg.2005.02.031. PMID 16125084.

External links

00520 at CHORUS

UpToDate Contents

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1. 副腎の外科解剖学 surgical anatomy of the adrenal glands
2. 頭部および頚部の傍神経節腫 paragangliomas of the head and neck

English Journal

Primary Retroperitoneal Inter-aorto-Caval Paraganglioma of the Organ of Zuckerkandl.

Vikas V1, Ahmed Z1, Singh O1, Pal SS2, Songra MC3.
Journal of clinical and diagnostic research : JCDR.J Clin Diagn Res.2014 Jul;8(7):ND06-7. doi: 10.7860/JCDR/2014/6781.4619. Epub 2014 Jul 20.
Tumour that arise from chromaffin cells at extra-adrenal locations are termed paragangliomas which are rare tumour. The organ of Zuckerkandl located along aortic bifurcation is the most common site of their occurrence. Herein, we report a case of 20-year-old male with large abdomino-pelvic paragangl
PMID 25177602

Role of rapid sequence whole-body MRI screening in SDH-associated hereditary paraganglioma families.

Jasperson KW1, Kohlmann W, Gammon A, Slack H, Buchmann L, Hunt J, Kirchhoff AC, Baskin H, Shaaban A, Schiffman JD.
Familial cancer.Fam Cancer.2014 Jun;13(2):257-65. doi: 10.1007/s10689-013-9639-6.
Patients with germline mutations in one of the SDH genes are at substantially increased risk of developing paragangliomas, pheochromocytomas (pheos), and other tumors (all combined referred to as SDH-related tumors). However, limited data exist on screening in SDH mutation carriers and no studies ha
PMID 23934599

Malignant melanotic schwannian tumor: a clinicopathologic, immunohistochemical, and gene expression profiling study of 40 cases, with a proposal for the reclassification of "melanotic schwannoma".

Torres-Mora J1, Dry S, Li X, Binder S, Amin M, Folpe AL.
The American journal of surgical pathology.Am J Surg Pathol.2014 Jan;38(1):94-105. doi: 10.1097/PAS.0b013e3182a0a150.
Melanotic schwannomas (MSs), variably associated with the Carney complex, are rare tumors that usually involve spinal nerve roots but may occur in other locations. Clinicopathologic evaluation poorly predicts the behavior of MS. Fewer than 200 cases have been reported. We report a series of 40 well-
PMID 24145644

Japanese Journal

エピネフリンが異常高値を示した副腎外褐色細胞腫の一例

菅原隆,清水公,瀬川郁夫
日本内分泌学会雑誌 72(3), 551-560, 1996-05-20
… We reported a case of a 72-year-old man with an extra-adrenal pheochromocytoma secreting excessive epinephrine (E). … An upper gastrointestinal series and computed tomography of the abdomen revealed an ovoid mass (diameter, approximately 5×6 cm) overlying the abdominal aorta and the inferior vena cava between the second and the third lumbar vertebra. …
NAID 10009419976

42.Organ of Zuckerkandl 原発神経節芽腫の1例(第24回日本小児外科学会東海地方会)

大和俊信,角岡秀彦,神尾善郎
日本小児外科学会雑誌 27(6), 1074, 1991-10-20
NAID 110002090615

Fine-needle aspiration cytology of pheochromocytoma-ganglioneuroma of the organ of Zuckerkandl

TANAKA T.
Diagn. Cytopathol 5, 64-68, 1989
NAID 30025947075

Related Pictures

★リンクテーブル★

リンク元	「傍神経節」「ツッカーカンドル器官」「Zuckerkandl器官」「para-aortic body」
関連記事	「organ」

「傍神経節」

Organ of Zuckerkandl
	The abdominal aorta and its branches. (Organ of Zuckerkandl is not shown, but it usually appears alongside the abdominal aorta.)
Identifiers
TA	A12.2.04.003
FMA	15647
	Anatomical terminology