WordNet

a silvery soft waxy metallic element of the alkali metal group; occurs abundantly in natural compounds (especially in salt water); burns with a yellow flame and reacts violently in water; occurs in sea water and in the mineral halite (rock salt) (同)Na, atomic number 11

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ソジウム,ナトリウム(金属元素;化学記号はNa)

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/07/18 20:52:31」(JST)

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Olsalazine is an anti-inflammatory drug used in the treatment of inflammatory bowel disease such as ulcerative colitis. It is sold under the name Dipentum.

The chemical name is 3,3' -azobis (6-hydroxybenzoate)salicylic acid. It is sold as the disodium salt.

Like balsalazide, olsalazine is believed to deliver mesalazine, or 5-aminosalicylic acid (5-ASA), past the small intestine, directly to the large intestine, which is the active site of disease in ulcerative colitis.

History

Olsalazine gained Food and Drug Administration (FDA) approval in 1990.

Supply

The drug is supplied by UCB Pharma.

Other indications

The Australian biotech company Giaconda has developed a combination therapy for treating constipation-predominant irritable bowel syndrome that uses olsalazine and the anti-gout drug colchicine.

External links

Olsalazine official site
Medicine Net

This drug article relating to the gastrointestinal system is a stub. You can help Wikipedia by expanding it.

UpToDate Contents

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1. 炎症性腸疾患治療におけるスルファサラジンおよび5-アミノサリチル酸 sulfasalazine and 5 aminosalicylates in the treatment of inflammatory bowel disease
2. 小児および思春期における軽度～中等度潰瘍性大腸炎のマネージメント management of mild to moderate ulcerative colitis in children and adolescents
3. 成人における軽症～中等症クローン病の内科的マネージメントの概要 overview of the medical management of mild to moderate crohn disease in adults
4. 小児および思春期におけるクローン病マネージメントの概要 overview of the management of crohn disease in children and adolescents
5. 炎症性腸疾患治療のための抗菌薬 antibiotics for treatment of inflammatory bowel diseases

English Journal

Technetium-99 m labeling and evaluation of olsalazine: a novel agent for ulcerative colitis imaging.

El-Kawy OA1, Ibrahim IT1, Farah K1.
Journal of labelled compounds & radiopharmaceuticals.J Labelled Comp Radiopharm.2015 Jun 1. doi: 10.1002/jlcr.3306. [Epub ahead of print]
Ulcerative colitis is a chronic disease having a regressive nature. Commonly used diagnostic methods have the disadvantage to be invasive, time-consuming, and expensive. Therefore, a new sensitive method for the detection and monitoring of disease activity is urgently needed in clinical practice. In
PMID 26031480

On the colonic bacterial metabolism of azo-bonded prodrugsof 5-aminosalicylic acid.

Sousa T1, Yadav V, Zann V, Borde A, Abrahamsson B, Basit AW.
Journal of pharmaceutical sciences.J Pharm Sci.2014 Oct;103(10):3171-5. doi: 10.1002/jps.24103. Epub 2014 Aug 4.
Azo-bonded prodrugs of 5-aminosalicylic acid (mesalazine)-sulfasalazine, balsalazide, and olsalazine, which are used in the treatment of ulcerative colitis, rely on colonic bacteria to cleave the azo bond and liberate the active drug in the large intestine. The aim of this study was to use an in vit
PMID 25091594

Role of pharmacoepidemiology studies in addressing pharmacovigilance questions: a case example of pancreatitis risk among ulcerative colitis patients using mesalazine.

Russo L1, Schneider G, Gardiner MH, Lanes S, Streck P, Rosen S.
European journal of clinical pharmacology.Eur J Clin Pharmacol.2014 Jun;70(6):709-17. doi: 10.1007/s00228-014-1660-7. Epub 2014 Mar 11.
PURPOSE: Well-designed pharmacoepidemiology studies address several limitations of postmarketing spontaneous reports in regard to signal evaluation. This study evaluated a signal of disproportionate reporting of acute pancreatitis cases observed in patients with ulcerative colitis (UC) treated with
PMID 24609467

Japanese Journal

Experimental colitis induced by dextran sulphate sodium in mice : beneficial effects of sulphasalazine and olsalazine

AXELSSON LG
Aliment Pharmacol Ther 12, 925-934, 1998
NAID 30004881637

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★リンクテーブル★

リンク元	「オルサラジン」「オルサラジンナトリウム」
関連記事	「olsalazine」

「オルサラジン」

Olsalazine
Systematic (IUPAC) name
	5-[(2Z)-2-(3-carboxy-4-oxocyclohexa-2,5-dien-1-ylidene)hydrazino]-2-hydroxybenzoic acid
Clinical data
Trade names	Dipentum
AHFS/Drugs.com	monograph
MedlinePlus	a601088
Pregnancy; category	US: C (Risk not ruled out);
Legal status	US: ℞-only;
Pharmacokinetic data
Protein binding	99%
Biological half-life	0.9 hours
Identifiers
CAS Registry Number	15722-48-2
ATC code	A07EC03
PubChem	CID: 6003770
DrugBank	DB01250
ChemSpider	10642377
UNII	ULS5I8J03O
KEGG	D00727
ChEMBL	CHEMBL571540
Chemical data
Formula	C14H10N2O6
Molecular mass	302.239g/mol
	SMILES O=C(O)c1cc(ccc1O)/N=N/c2cc(C(O)=O)c(O)cc2 ;
	InChI InChI=1S/C14H10N2O6/c17-11-3-1-7(5-9(11)13(19)20)15-16-8-2-4-12(18)10(6-8)14(21)22/h1-6,17-18H,(H,19,20)(H,21,22)/b16-15+ ; Key:QQBDLJCYGRGAKP-FOCLMDBBSA-N ;
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