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English Journal

Abd Elrazek AE1, Eid KA, El-Sherif AE, Abd El Al UM, El-Sherbiny SM, Bilasy SE.
European journal of gastroenterology & hepatology.Eur J Gastroenterol Hepatol.2015 Jan;27(1):8-12. doi: 10.1097/MEG.0000000000000196.
OBJECTIVE: Cost-effectiveness analysis is an approach used to determine the value of a medical care option and refers to a method used to assess the costs and health benefits of an intervention. Upon the diagnosis of liver cirrhosis, the current guidelines recommend that all cirrhotic patients have
PMID 25304250

The Ability to Diagnose Intrahepatic Cholangiocarcinoma Definitively Using Novel Branched DNA-Enhanced Albumin RNA In Situ Hybridization Technology.

Ferrone CR1, Ting DT, Shahid M, Konstantinidis IT, Sabbatino F, Goyal L, Rice-Stitt T, Mubeen A, Arora K, Bardeesey N, Miura J, Gamblin TC, Zhu AX, Borger D, Lillemoe KD, Rivera MN, Deshpande V.
Annals of surgical oncology.Ann Surg Oncol.2014 Dec 18. [Epub ahead of print]
BACKGROUND: Intrahepatic cholangiocarcinoma (ICC) often is a diagnosis determined by exclusion. Distinguishing ICC from other metastatic adenocarcinomas based on histopathologic or immunohistochemical analysis often is difficult and requires an extensive workup. This study aimed to determine whether
PMID 25519926

Protein kinase Cδ protects against bile acid apoptosis by suppressing proapoptotic JNK and BIM pathways in human and rat hepatocytes.

Webster CR1, Johnston AN2, Anwer MS3.
American journal of physiology. Gastrointestinal and liver physiology.Am J Physiol Gastrointest Liver Physiol.2014 Dec 15;307(12):G1207-15. doi: 10.1152/ajpgi.00165.2014. Epub 2014 Oct 30.
Retained bile acids, which are capable of inducing cell death, activate protein kinase Cδ (PKC-δ) in hepatocytes. In nonhepatic cells, both pro- and antiapoptotic effects of PKC-δ are described. The aim of this study was to determine the role of PKC-δ in glycochenodeoxycholate (GCDC)-induced apo
PMID 25359536