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English Journal

Differential expression of human cytochrome P450 enzymes from the CYP3A subfamily in the brains of alcoholic subjects and drug-free controls.

Booth Depaz IM, Toselli F, Wilce PA, Gillam EM.SourceSchool of Biomedical Sciences, The University of Queensland, Brisbane, Queensland, Australia.
Drug metabolism and disposition: the biological fate of chemicals.Drug Metab Dispos.2013 Jun;41(6):1187-94. doi: 10.1124/dmd.113.051359. Epub 2013 Mar 14.
Cytochrome P450 enzymes are responsible for the metabolism of most commonly used drugs. Among these enzymes, CYP3A forms mediate the clearance of around 40-50% of drugs and may also play roles in the biotransformation of endogenous compounds. CYP3A forms are expressed both in the liver and extrahepa
PMID 23491640

Cytochrome P450 enzymes in drug metabolism: regulation of gene expression, enzyme activities, and impact of genetic variation.

Zanger UM, Schwab M.SourceDr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, Auerbachstr. 112 D, 70376 Stuttgart, Germany. uli.zanger@ikp-stuttgart.de
Pharmacology & therapeutics.Pharmacol Ther.2013 Apr;138(1):103-41. doi: 10.1016/j.pharmthera.2012.12.007. Epub 2013 Jan 16.
Cytochromes P450 (CYP) are a major source of variability in drug pharmacokinetics and response. Of 57 putatively functional human CYPs only about a dozen enzymes, belonging to the CYP1, 2, and 3 families, are responsible for the biotransformation of most foreign substances including 70-80% of all dr
PMID 23333322

Extrahepatic Glissonean approach for laparoscopic major liver resection (with video).

Cho A, Yamamoto H, Kainuma O, Ota T, Park S, Arimitsu H, Ikeda A, Souda H, Nabeya Y, Takiguchi N, Nagata M.SourceDivision of Gastroenterological Surgery, Chiba Cancer Center Hospital, 666-2 Nitonachou, Chuou-ku, Chiba 260-8717, Japan. acho@chiba-cc.jp
Journal of hepato-biliary-pancreatic sciences.J Hepatobiliary Pancreat Sci.2013 Feb;20(2):141-4. doi: 10.1007/s00534-012-0559-x.
Although recent technological developments and improved endoscopic procedures have further spread the application of laparoscopic liver resection, laparoscopic major liver resection remains a highly specialized field because there are major technical difficulties, such as hilar dissection and pedicl
PMID 23001193