mitotic catastrophe

分裂死、分裂期細胞死

WordNet

1. a sudden violent change in the earths surface (同)cataclysm
2. a state of extreme (usually irremediable) ruin and misfortune; "lack of funds has resulted in a catastrophe for our school system"; "his policies were a disaster" (同)disaster
3. of or relating to or undergoing mitosis

PrepTutorEJDIC

1. (突然の)大変動,大災害 / 悲劇的結末,破局

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2013/10/15 18:23:33」(JST)

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[Wiki en表示]

Mitotic catastrophe is an event in which a cell is destroyed during mitosis. This is believed by some to occur as a result of an attempt at aberrant chromosome segregation early in mitosis, or as a result of DNA damage later.

The term ‘mitotic catastrophe’ is used to explain a mechanism of a delayed mitotic-linked cell death, a sequence of events that results from premature or inappropriate entry of cells into mitosis that can be caused by chemical or physical stresses. It can be triggered with agents influencing the stability of microtubule, various anticancer drugs and mitotic failure caused by defective cell cycle checkpoints. Mitotic catastrophe is the main form of cell death induced by ionizing radiation

Cells which fail to go through a mitotic catastrophe after a mitotic failure are likely to create aneuploid cells when they later reproduce, posing a risk of oncogenesis, potentially leading to cancer.

External links

• Castedo M, Perfettini JL, Roumier T, Andreau K, Medema R, Kroemer G. (12 April 2004). "Cell death by mitotic catastrophe: a molecular definition". Oncogene 23 (16): 2825–2837. doi:10.1038/sj.onc.1207528. ISSN 0950-9232. PMID 15077146. 

Chow, J.P.H. and Poon, R.Y.C. (2010) Mitotic catastrophe. Cell Cycle Deregulation in Cancer p.79-96. Ed. Greg Enders. Springer, New York.

Vakifahmetoglu H, Olsson M, Zhivotovsky B. Death through a tragedy: mitotic catastrophe. Cell Death Differ 2008; 15: 1153–1162. url = http://www.apo-sys.eu/aposys/Publications/Publications2008-pdf/Vakifahmetoglu-tragedy.pdf

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English Journal

• Mechanism of the antiproliferative activity of some naphthalene diimide g-quadruplex ligands.

• Hampel SM, Pepe A, Greulich-Bode KM, Malhotra SV, Reszka AP, Veith S, Boukamp P, Neidle S.SourceUCL School of Pharmacy, University College London, London, WC1N 1AX, UK. s.neidle@ucl.ac.uk.
• Molecular pharmacology.Mol Pharmacol.2013 Feb;83(2):470-80. doi: 10.1124/mol.112.081075. Epub 2012 Nov 27.
• G-quadruplexes are higher-order nucleic acid structures that can form in G-rich telomeres and promoter regions of oncogenes. Telomeric quadruplex stabilization by small molecules can lead to telomere uncapping, followed by DNA damage response and senescence, as well as chromosomal fusions leading to
• PMID 23188717

• RPF101, a new capsaicin-like analogue, disrupts the microtubule network accompanied by arrest in the G2/M phase, inducing apoptosis and mitotic catastrophe in the MCF-7 breast cancer cells.

• de-Sá-Júnior PL, Pasqualoto KF, Ferreira AK, Tavares MT, Damião MC, de Azevedo RA, Câmara DA, Pereira A, de Souza DM, Parise Filho R.SourceLaboratory of Genetics, Butantan Institute, Vital Brasil Avenue 1500, Postal Code: 05503-900, Sao Paulo, Brazil.
• Toxicology and applied pharmacology.Toxicol Appl Pharmacol.2013 Feb 1;266(3):385-98. doi: 10.1016/j.taap.2012.11.029. Epub 2012 Dec 10.
• Breast cancer is the world's leading cause of death among women. This situation imposes an urgent development of more selective and less toxic agents. The use of natural molecular fingerprints as sources for new bioactive chemical entities has proven to be a quite promising and efficient method. Cap
• PMID 23238560

Japanese Journal

• High LET Radiation Amplifies Centrosome Overduplication Through a Pathway of γ-Tubulin Monoubiquitination.

• Shimada Mikio,Hirayama Ryoichi,Komatsu Kenshi
• International journal of radiation oncology, biology, physics 86(2), 358-365, 2013-06-01
• … [Purpose]Radiation induces centrosome overduplication, leading to mitotic catastrophe and tumorigenesis. … Because mitotic catastrophe is one of the major tumor cell killing factors in high linear energy transfer (LET) radiation therapy and long-term survivors from such treatment have a potential risk of secondary tumors, we investigated LET dependence of radiation-induced centrosome overduplication and the underlying mechanism. …
• NAID 120005245135

• Radiation-induced Cell Death and its Mechanisms

• Kondo Takashi
• Radiation emergency medicine 2(1), 1-4, 2013-02
• NAID 40019561809

• Pseudolaric Acid B–Induced Autophagy Contributes to Senescence via Enhancement of ROS Generation and Mitochondrial Dysfunction in Murine Fibrosarcoma L929 Cells

• Qi Min,Fan Simiao,Yao Guodong,Li Zhao,Zhou Haiyan,Tashiro Shin-ichi,Onodera Satoshi,Xia Mingyu,Ikejima Takashi
• Journal of Pharmacological Sciences 121(3), 200-211, 2013
• … Our previous study demonstrated that PAB induced mitotic catastrophe in L929 cells and indicated that only a small percentage (12%) of the cells undergoing mitotic catastrophe displayed an apoptotic phenotype after PAB treatment for 72 h. … In this study, we found that a minority of the cells undergoing mitotic catastrophe ended in apoptosis, and a majority of them entered a period of senescence. …
• NAID 130003362687

Related Links

• Mitotic catastrophe - Wikipedia, the free encyclopedia

Mitotic catastrophe is an event in which a cell is destroyed during mitosis. This is believed by some to occur as a result of an attempt at aberrant chromosome segregation early in mitosis, or as a result of DNA damage later. The term 'mitotic ...

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★リンクテーブル★

リンク元	「分裂死」「分裂期細胞死」
関連記事	「mitotic」「catastrophe」

「分裂死」

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mitotic catastrophe

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分裂期細胞死

「分裂期細胞死」

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英

mitotic catastrophe

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分裂死

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mitoses、mitosis

　

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• カタストロフ、破局