English Journal

Imidazole-stabilized gold nanoparticles induce neuronal apoptosis: an in vitro and in vivo study.

Imperatore R1, Carotenuto G, Di Grazia MA, Ferrandino I, Palomba L, Mariotti R, Vitale E, De Nicola S, Longo A, Cristino L.
Journal of biomedical materials research. Part A.J Biomed Mater Res A.2015 Apr;103(4):1436-46. doi: 10.1002/jbm.a.35289. Epub 2014 Aug 2.
Gold nanoparticles are increasingly being employed in innovative biological applications thanks to their advantages of material- and size-dependent physics and chemical interactions with the cellular systems. On the other hand, growing concern has emerged on the toxicity which would render gold-base
PMID 25046830

Inhibitory effects of novel synthetic methimazole derivatives on mushroom tyrosinase and melanogenesis.

Chan CF1, Lai ST2, Guo YC2, Chen MJ3.
Bioorganic & medicinal chemistry.Bioorg Med Chem.2014 May 1;22(9):2809-15. doi: 10.1016/j.bmc.2014.03.009. Epub 2014 Mar 15.
In this study, we synthesized 4 methimazole (2-mercapto-1-methylimidazole, MMI) derivatives. The kinetics of inhibition on mushroom tyrosinase by methimazole and its derivatives were investigated. The results indicated that tert-butyl 3-methyl-2-sulfanylidene-2,3-dihydro-1H-imidazole-1-carboxylate (
PMID 24703463

Au-Ag-Au double shell nanoparticles-based localized surface plasmon resonance and surface-enhanced Raman scattering biosensor for sensitive detection of 2-mercapto-1-methylimidazole.

Liao X1, Chen Y, Qin M, Chen Y, Yang L, Zhang H, Tian Y.
Talanta.Talanta.2013 Dec 15;117:203-8. doi: 10.1016/j.talanta.2013.08.051. Epub 2013 Sep 14.
In this paper, Au-Ag-Au double shell nanoparticles were prepared based on the reduction of the metal salts HAuCl4 and AgNO3 at the surface of seed particles. Due to the synergistic effect between Au and Ag, the hybrid nanoparticles are particularly stable and show excellent performances on the detec
PMID 24209331