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1. 非中毒性非閉塞性甲状腺腫の治療treatment of nontoxic nonobstructive goiter [show details]
…for the treatment of nontoxic goiter. Due to high dietary iodine intake, thyroid iodine uptake is typically low in patients with nontoxic goiter, and therefore, a relatively high dose of radioiodine is required …
2. 鉄キレート薬：選択肢、投与量、副作用iron chelators choice of agent dosing and adverse effects [show details]
… inadequate chelation, requiring intensification of treatment. Options include escalation to maximal allowed doses, switching to another chelating agent if compliance with the current agent has been inadequate …
3. トリメトプリムスルファメトキサゾール：概要trimethoprim sulfamethoxazole an overview [show details]
… Dosing of TMP-SMX is based on the trimethoprim component and expressed as a mg/kg per day of TMP. Oral doses of TMP-SMX are usually given… Maximal synergistic action occurs when microorganisms are susceptible to both drugs.…
4. プロトンポンプ阻害薬：胃酸分泌が関与する疾患への使用と副作用の概要proton pump inhibitors overview of use and adverse effects in the treatment of acid related disorders [show details]
…60 minutes before breakfast for maximal inhibition of proton pumps. PPI doses typically used in the treatment of acid-related disorders are listed in the table Dose reduction, particularly for maintenance …
5. COX-2選択的阻害剤の概要overview of selective cox 2 inhibitors [show details]
…elsewhere at doses of 7.5 and 15 mg once per day. As with etodolac, meloxicam principally inhibits the activity of COX-2 at low doses, while it has more effects upon COX-1 at higher doses. This loss of …

English Journal

Deciphering the potential of baicalin as an antiviral agent for Chikungunya virus infection.

Oo A, Rausalu K, Merits A, Higgs S, Vanlandingham D, Bakar SA, Zandi K.
Antiviral research. 2018 02;150()101-111.
The past decade has seen the re-emergence of Chikungunya virus (CHIKV) as a major global health threat, affecting millions around the world. Although fatal infections are rare among infected patients, the occurrence of long-lasting polyarthralgia has a significant impact on patients' quality of live
PMID 29269135

Identification of rosmarinic acid and sulfated flavonoids as inhibitors of microfouling on the surface of eelgrass Zostera marina.

Guan C, Parrot D, Wiese J, Sönnichsen FD, Saha M, Tasdemir D, Weinberger F.
Biofouling. 2017 11;33(10)867-880.
A bioassay-guided approach was used to identify defense compounds that are present on the surface of Zostera marina and which inhibit settlement of microfoulers at natural concentrations. Moderately polar eelgrass surface extracts inhibited the settlement of seven marine bacteria and one yeast that
PMID 29032711

Sensitization of gastric cancer cells to alkylating agents by glaucocalyxin B via cell cycle arrest and enhanced cell death.

Ur Rahman MS, Zhang L, Wu L, Xie Y, Li C, Cao J.
Drug design, development and therapy. 2017 ;11()2431-2441.
Severe side effects are major problems with chemotherapy of gastric cancer (GC). These side effects can be reduced by using sensitizing agents in combination with therapeutic drugs. In this study, the low/nontoxic dosage of glaucocalyxin B (GLB) was used with other DNA linker agents mitomycin C (MMC
PMID 28860714

Japanese Journal

Chrysin Inhibits Lymphangiogenesis <i>in Vitro</i>

Prangsaengtong Orawin,Athikomkulchai Sirivan,Xu Jiuxiang,Koizumi Keiichi,Inujima Akiko,Shibahara Naotoshi,Shimada Yutaka,Tadtong Sarin,Awale Suresh
Ｂｉｏｌｏｇｉｃａｌ　＆　Ｐｈａｒｍａｃｅｕｔｉｃａｌ　Ｂｕｌｌｅｔｉｎ 39(4), 466-472, 2016
… In this study, maximal nontoxic doses of chrysin on TR-LE cells were selected by performing a proliferation assay. … Chrysin at a nontoxic dose (25 μM) significantly inhibited cord formation, cell adhesion and migration of TR-LE cells when compared with the control group. …
NAID 130005141688