WordNet

any of a large group of nitrogenous organic compounds that are essential constituents of living cells; consist of polymers of amino acids; essential in the diet of animals for growth and for repair of tissues; can be obtained from meat and eggs and milk and legumes; "a diet high in protein"
characterized or caused by inflammation; "an inflammatory process"; "an inflammatory response"
a large phagocyte; some are fixed and other circulate in the blood stream

PrepTutorEJDIC

蛋白(たんばく)質
炎症を起こす,炎症性の / 憤激させる,扇動的な

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/02/07 00:18:48」(JST)

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Macrophage Inflammatory Proteins (MIP) belong to the family of chemotactic cytokines known as chemokines. In humans, there are two major forms, MIP-1α and MIP-1β that are now officially named CCL3 and CCL4, respectively. Both are major factors produced by macrophages after they are stimulated with bacterial endotoxins.^[3] They are crucial for immune responses towards infection and inflammation.^[4] They activate human granulocytes (neutrophils, eosinophils and basophils) which can lead to acute neutrophilic inflammation. They also induce the synthesis and release of other pro-inflammatory cytokines such as interleukin 1 (IL-1), IL-6 and TNF-α from fibroblasts and macrophages. The genes for CCL3 and CCL4 are both located on human chromosome 17.^[5]

They are produced by many cells, particularly macrophages, dendritic cells, and lymphocytes.^[6] MIP-1 are best known for their chemotactic and proinflammatory effects but can also promote homoeostasis.^[6] Biophysical analyses and mathematical modelling has shown that MIP-1 reversibly forms a polydisperse distribution of rod-shaped polymers in solution. Polymerization buries receptor-binding sites of MIP-1, thus depolymerization mutations enhance MIP-1 to arrest monocytes onto activated human endothelium.^[4]

References

^ Czaplewski, L. G.; McKeating, J.; Craven, C. J.; Higgins, L. D.; Appay, V.; Brown, A.; Dudgeon, T.; Howard, L. A.; Meyers, T.; Owen, J.; Palan, S. R.; Tan, P.; Wilson, G.; Woods, N. R.; Heyworth, C. M.; Lord, B. I.; Brotherton, D.; Christison, R.; Craig, S.; Cribbes, S.; Edwards, R. M.; Evans, S. J.; Gilbert, R.; Morgan, P.; Randle, E.; Schofield, N.; Varley, P. G.; Fisher, J.; Waltho, J. P.; Hunter, M. G. (1999). "Identification of amino acid residues critical for aggregation of human CC chemokines macrophage inflammatory protein (MIP)-1alpha, MIP-1beta, and RANTES. Characterization of active disaggregated chemokine variants". The Journal of Biological Chemistry 274 (23): 16077–16084. doi:10.1074/jbc.274.23.16077. PMID 10347159.
^ Lodi, P. J.; Garrett, D. S.; Kuszewski, J.; Tsang, M. L.; Weatherbee, J. A.; Leonard, W. J.; Gronenborn, A. M.; Clore, G. M. (1994). "High-resolution solution structure of the beta chemokine hMIP-1 beta by multidimensional NMR". Science 263 (5154): 1762–1767. doi:10.1126/science.8134838. PMID 8134838.
^ Sherry B, Tekamp-Olson P, Gallegos C, Bauer D, Davatelis G, Wolpe SD, Masiarz F, Coit D, Cerami A (December 1988). "Resolution of the two components of macrophage inflammatory protein 1, and cloning and characterization of one of those components, macrophage inflammatory protein 1 beta". J. Exp. Med. 168 (6): 2251–9. doi:10.1084/jem.168.6.2251. PMC 2189160. PMID 3058856.
^ ^a ^b Ren M, Guo Q, Guo L, et al. (December 2010). "Polymerization of MIP-1 chemokine (CCL3 and CCL4) and clearance of MIP-1 by insulin-degrading enzyme". EMBO J. 29 (23): 3952–66. doi:10.1038/emboj.2010.256. PMC 3020635. PMID 20959807.
^ Irving SG, Zipfel PF, Balke J, McBride OW, Morton CC, Burd PR, Siebenlist U, Kelly K (June 1990). "Two inflammatory mediator cytokine genes are closely linked and variably amplified on chromosome 17q". Nucleic Acids Res. 18 (11): 3261–70. doi:10.1093/nar/18.11.3261. PMC 330932. PMID 1972563.
^ ^a ^b Maurer M, von Stebut E (October 2004). "Macrophage inflammatory protein-1". Int. J. Biochem. Cell Biol. 36 (10): 1882–6. doi:10.1016/j.biocel.2003.10.019. PMID 15203102.

External links

Macrophage Inflammatory Proteins at the US National Library of Medicine Medical Subject Headings (MeSH)

This article on a gene on human chromosome 17 is a stub. You can help Wikipedia by expanding it.

This cell biology article is a stub. You can help Wikipedia by expanding it.

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English Journal

Attenuation of acute stroke injury in rat brain by minocycline promotes blood-brain barrier remodeling and alternative microglia/macrophage activation during recovery.

Yang Y1, Salayandia VM, Thompson JF, Yang LY, Estrada EY, Yang Y.
Journal of neuroinflammation.J Neuroinflammation.2015 Dec;12(1):245. doi: 10.1186/s12974-015-0245-4. Epub 2015 Feb 10.
BACKGROUND: Minocycline reduces reperfusion injury by inhibiting matrix metalloproteinases (MMPs) and microglia activity after cerebral ischemia. Prior studies of minocycline investigated short-term neuroprotective effects during subacute stage of stroke; however, the late effects of minocycline aga
PMID 25779432

Inflammation and pathological damage to the lungs of mice are only partially reversed following smoking cessation on subacute exposure to cigarette smoke.

Yan H1, Zhao L1, Wu X1, Liu H1, Wu C1, Li Y1, Zheng W1, Jiang H1.
Molecular medicine reports.Mol Med Rep.2015 Jun;11(6):4246-54. doi: 10.3892/mmr.2015.3337. Epub 2015 Feb 11.
The present study aimed to observe the level of inflammation and the number of lesions in the airways and parenchyma of mouse lungs subsequent to smoking cessation following 4 weeks exposure to cigarette smoke. Enlargement of the regional airspaces, deposition of peribronchial collagen fibers and m
PMID 25672547

Japanese Journal

Omega 3 Polyunsaturated Fatty Acids Suppress the Development of Aortic Aneurysms Through the Inhibition of Macrophage-Mediated Inflammation

, , , , , , , , , ,
Circulation Journal advpub(0), 2015
… The effects of ω3-PUFAs on abdominal aortic aneurysm (AAA) formation and macrophage-mediated inflammation remain unclear.Methods and Results:The AAA model was developed by angiotensin II infusion in apolipoprotein E-deficient mice. … The development of AAA lesions and macrophage infiltration in the aorta were analyzed. … Gene expression of inflammatory markers in aortic tissues and peritoneal macrophages were measured by using quantitative polymerase chain reaction. …
NAID 130005068466

Expression of Fgf23 in Activated Dendritic Cells and Macrophages in Response to Immunological Stimuli in Mice

, , , , , ,
Biological and Pharmaceutical Bulletin 38(5), 687-693, 2015
… Moreover, we examined the effects of recombinant Fgf23 protein on immune cells in vitro. … Collectively, these data suggest that Fgf23 might be intimately involved in inflammatory processes. …
NAID 130005068085

Related Pictures

★リンクテーブル★

リンク元	「マクロファージ炎症性タンパク質」
拡張検索	「macrophage inflammatory protein-1」「macrophage inflammatory protein 1alpha」
関連記事	「inflammatory」

「マクロファージ炎症性タンパク質」

chemokine (C-C motif) ligand 4
	Human Mip-1β dimer. PDB 1hum. Disulfide bonds highlighted.
Identifiers
Symbol	CCL4
Alt. symbols	SCYA4, MIP-1β, LAG1
Entrez	6351
HUGO	10630
OMIM	182284
PDB	1HUM More structures
RefSeq	NM_002984
UniProt	P13236
Other data
Locus	Chr. 17 q21-q23

chemokine (C-C motif) ligand 3
	Human Mip-1α dimer D26A mutant. PDB 1b53. Disulfide bonds highlighted.
Identifiers
Symbol	CCL3
Alt. symbols	SCYA3, MIP-1α
Entrez	6348
HUGO	10627
OMIM	182283
PDB	1B50 More structures
RefSeq	NM_002983
UniProt	P10147
Other data
Locus	Chr. 17 q12

　　[★]

英: macrophage inflammatory protein、MIP
関: マクロファージ炎症性タンパク質-1

「macrophage inflammatory protein-1」

　　[★]

マクロファージ炎症性タンパク質-1

関: macrophage inflammatory protein

「macrophage inflammatory protein 1alpha」

　　[★]

マクロファージ炎症性タンパク質1α

関: MIP-1alpha

「inflammatory」

　　[★]

adj.

炎症性の、炎症の、起炎性の

関: inflamed、inflammation、-itis、phlogogenous、prophlogistic

[1] Czaplewski, L. G.; McKeating, J.; Craven, C. J.; Higgins, L. D.; Appay, V.; Brown, A.; Dudgeon, T.; Howard, L. A.; Meyers, T.; Owen, J.; Palan, S. R.; Tan, P.; Wilson, G.; Woods, N. R.; Heyworth, C. M.; Lord, B. I.; Brotherton, D.; Christison, R.; Craig, S.; Cribbes, S.; Edwards, R. M.; Evans, S. J.; Gilbert, R.; Morgan, P.; Randle, E.; Schofield, N.; Varley, P. G.; Fisher, J.; Waltho, J. P.; Hunter, M. G. (1999). "Identification of amino acid residues critical for aggregation of human CC chemokines macrophage inflammatory protein (MIP)-1alpha, MIP-1beta, and RANTES. Characterization of active disaggregated chemokine variants". The Journal of Biological Chemistry 274 (23): 16077–16084. doi:10.1074/jbc.274.23.16077. PMID 10347159.

[2] Lodi, P. J.; Garrett, D. S.; Kuszewski, J.; Tsang, M. L.; Weatherbee, J. A.; Leonard, W. J.; Gronenborn, A. M.; Clore, G. M. (1994). "High-resolution solution structure of the beta chemokine hMIP-1 beta by multidimensional NMR". Science 263 (5154): 1762–1767. doi:10.1126/science.8134838. PMID 8134838.

[pmid3058856-3] Sherry B, Tekamp-Olson P, Gallegos C, Bauer D, Davatelis G, Wolpe SD, Masiarz F, Coit D, Cerami A (December 1988). "Resolution of the two components of macrophage inflammatory protein 1, and cloning and characterization of one of those components, macrophage inflammatory protein 1 beta". J. Exp. Med. 168 (6): 2251–9. doi:10.1084/jem.168.6.2251. PMC 2189160. PMID 3058856.

[pmid20959807-4] Ren M, Guo Q, Guo L, et al. (December 2010). "Polymerization of MIP-1 chemokine (CCL3 and CCL4) and clearance of MIP-1 by insulin-degrading enzyme". EMBO J. 29 (23): 3952–66. doi:10.1038/emboj.2010.256. PMC 3020635. PMID 20959807.

[pmid1972563-5] Irving SG, Zipfel PF, Balke J, McBride OW, Morton CC, Burd PR, Siebenlist U, Kelly K (June 1990). "Two inflammatory mediator cytokine genes are closely linked and variably amplified on chromosome 17q". Nucleic Acids Res. 18 (11): 3261–70. doi:10.1093/nar/18.11.3261. PMC 330932. PMID 1972563.

[pmid15203102-6] Maurer M, von Stebut E (October 2004). "Macrophage inflammatory protein-1". Int. J. Biochem. Cell Biol. 36 (10): 1882–6. doi:10.1016/j.biocel.2003.10.019. PMID 15203102.

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案内

macrophage inflammatory protein