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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/03/08 03:35:21」(JST)

Lomerizine (INN) is a calcium channel blocker^[1] with antimigraine properties.

§References

^ Selt M, Bartlett CA, Harvey AR, Dunlop SA, Fitzgerald M (November 2009). "Limited restoration of visual function after partial optic nerve injury; a time course study using the calcium channel blocker lomerizine". Brain Res. Bull. 81 (4–5): 467–471. doi:10.1016/j.brainresbull.2009.11.004. PMID 19913075.

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Changes in optic nerve head circulation in response to vasoactive agents: intereye comparison in monkeys with experimental unilateral glaucoma.

Mayama C, Ishii K, Ota T, Tomidokoro A, Araie M.SourceDepartment of Ophthalmology, the University of Tokyo Graduate School of Medicine, Tokyo, Japan. cmayama-tky@umin.ac.jp
Investigative ophthalmology & visual science.Invest Ophthalmol Vis Sci.2012 Aug 22;53(9):5771-8. doi: 10.1167/iovs.12-9765.
PURPOSE: To investigate circulatory changes in the optic nerve head (ONH) in response to vasoactive agents including calcium antagonists, a substrate of nitric oxide (NO), and an inhibitor of NO synthase (NOS) in monkeys with unilateral experimental glaucoma.METHODS: Argon laser cautery to the trabe
PMID 22714894

Neuroprotection by lomerizine, a prophylactic drug for migraine, against hydrogen peroxide-induced hippocampal neurotoxicity.

Ishii M, Iizuka R, Kiuchi Y, Mori Y, Shimizu S.SourceDepartment of Pathophysiology, School of Pharmaceutical Sciences, Showa University, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo 142-8555, Japan. masakazu@pharm.showa-u.ac.jp
Molecular and cellular biochemistry.Mol Cell Biochem.2011 Dec;358(1-2):1-11. doi: 10.1007/s11010-011-0913-3. Epub 2011 Jun 9.
Migraine is one of the risk factor for ischemic stroke. The purpose of this study was to examine the effect of lomerizine, a prophylactic drug for migraine, on H(2)O(2)-induced cell death of hippocampal neurons. Cytosolic Ca(2+) concentration was measured using fura-2 as a Ca(2+) indicator. Cell dea
PMID 21656126

症例報告ロメリジン投与にて脳梗塞抑制効果が示唆されたcerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL)の1例

ロメリジン投与にて脳梗塞抑制効果が示唆されたcerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy（CADASIL）の1例

清水久央,長見周平,高橋信行
臨床神経学 54(1), 22-26, 2014
症例は60歳の男性である．54歳時に左上下肢の麻痺にて来院．頭部MRIにて右放線冠に新鮮梗塞を，両側基底核や大脳深部白質に陳旧性脳梗塞をみとめた．抗血小板薬を投与したが，4度脳梗塞をくりかえした．家族歴からcerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy （CADAS …
NAID 130004921131

渡邉由佳,高嶋良太郎,岩波久威,鈴木紫布,五十嵐久佳,平田幸一
臨床神経学 53(11), 1228-1230, 2013
今年，日本神経学会，日本頭痛学会から慢性頭痛の診療ガイドライン2013が出版され，あらたに「慢性片頭痛はどのように治療するか」というCQが設けられた．2010年にバルプロ酸（VPA）が片頭痛治療に保険適用が追加になり，プロプラノロール，アミトリプチリン，ベラパミルも続き片頭痛治療は躍進した．エビデンスのある慢性片頭痛の薬物治療には，VPA，トピラマート（TPM），レベチラセタム，ガバペンチン，アミ …
NAID 130004505396

リンク元	「ロメリジン」
拡張検索	「lomerizine hydrochloride」

Lomerizine
Systematic (IUPAC) name
	1-[bis(4-fluorophenyl)methyl]-4-(2,3,4-trimethoxybenzyl)piperazine
Clinical data
AHFS/Drugs.com	International Drug Names
Legal status	℞ Prescription only;
Routes	Oral
Identifiers
CAS number	101477-55-8
ATC code	None
PubChem	CID 3949
ChemSpider	3812
UNII	DEE37CY4VO
ChEMBL	CHEMBL29188
Chemical data
Formula	C27H30F2N2O3
Molecular mass	468.53 g/mol
	SMILES COC1=C(C(=C(C=C1)CN2CCN(CC2)C(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F)OC)OC;
	InChI InChI=1S/C27H30F2N2O3/c1-32-24-13-8-21(26(33-2)27(24)34-3)18-30-14-16-31(17-15-30)25(19-4-9-22(28)10-5-19)20-6-11-23(29)12-7-20/h4-13,25H,14-18H2,1-3H3 ; Key:JQSAYKKFZOSZGJ-UHFFFAOYSA-N ;
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