WordNet

any of various water-soluble compounds capable of turning litmus blue and reacting with an acid to form a salt and water; "bases include oxides and hydroxides of metals and ammonia" (同)alkali
(numeration system) the positive integer that is equivalent to one in the next higher counting place; "10 is the radix of the decimal system" (同)radix
the bottom side of a geometric figure from which the altitude can be constructed; "the base of the triangle"
situate as a center of operations; "we will base this project in the new lab"
a place that the runner must touch before scoring; "he scrambled to get back to the bag" (同)bag
installation from which a military force initiates operations; "the attack wiped out our forward bases" (同)base of operations
a support or foundation; "the base of the lamp" (同)pedestal, stand
(electronics) the part of a transistor that separates the emitter from the collector
a flat bottom on which something is intended to sit; "a tub should sit on its own base"
the principal ingredient of a mixture; "glycerinated gelatin is used as a base for many ointments"; "he told the painter that he wanted a yellow base with just a hint of green"; "everything she cooked seemed to have rice as the base"
the place where you are stationed and from which missions start and end (同)home
(anatomy) the part of an organ nearest its point of attachment; "the base of the skull"
the bottom or lowest part; "the base of the mountain"
illegitimate (同)baseborn
of low birth or station (`base is archaic in this sense); "baseborn wretches with dirty faces"; "of humble (or lowly) birth" (同)baseborn, humble, lowly
not adhering to ethical or moral principles; "base and unpatriotic motives"; "a base, degrading way of life"; "cheating is dishonorable"; "they considered colonialism immoral"; "unethical practices in handling public funds" (同)immoral
having or showing an ignoble lack of honor or morality; "that liberal obedience without which your army would be a base rabble"- Edmund Burke; "taking a mean advantage"; "chokd with ambition of the meaner sort"- Shakespeare; "something essentially vulgar and meanspirited in politics" (同)mean, meanspirited
(used of metals) consisting of or alloyed with inferior metal; "base coins of aluminum"; "a base metal"
debased; not genuine; "an attempt to eliminate the base coinage"
a design or figure that consists of recurring shapes or colors, as in architecture or decoration (同)motive
a theme that is repeated or elaborated in a piece of music (同)motive
a substance that retards or stops an activity
having a base; "firmly based ice"
having a base of operations (often used as a combining form); "a locally based business"; "an Atlanta-based company"; "carrier-based planes"
restrictive of action; "a repressive regime"; "an overly strict and inhibiting discipline" (同)repressive, repressing

PrepTutorEJDIC

《文》(人や人の行動・孝えが)『卑しい』,下劣な / (金属が)質の劣った;(貨幣が)粗悪な
『基礎』,根拠 / 『基部』,基底,土台 / 『根拠地』,基地 / (野球の)塁,ベース / 主成分;塩基(酸と反応シテ塩(官)を生じる化合物) / (数学で図形の)底;底辺;基線 / (…に)…‘の'『基礎をおく』《+『名』+『on』(『upon』)+『名』》
モチーフ / 文学・芸術作品の表現の中心となる主題 / 楽曲の主題 / デザインなどに繰り返して用いられる主模様
抑制する人(物) / 化学反応抑制剤

UpToDate Contents

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1. 肥満細胞：表面受容体とシグナル伝達 mast cells surface receptors and signal transduction
2. T細胞受容体シグナル伝達 t cell receptor signaling
3. 慢性骨髄性白血病の治療の概要 overview of the treatment of chronic myeloid leukemia
4. チロシン代謝障害 disorders of tyrosine metabolism
5. NK細胞欠損症候群：臨床症状および診断 nk cell deficiency syndromes clinical manifestations and diagnosis

English Journal

V‑set and transmembrane domain‑containing 1 is silenced in human hematopoietic malignancy cell lines with promoter methylation and has inhibitory effects on cell growth.

Li T1, Guo X1, Wang W1, Mo X1, Wang P1, Han W1.
Molecular medicine reports.Mol Med Rep.2015 Feb;11(2):1344-51. doi: 10.3892/mmr.2014.2785. Epub 2014 Oct 27.
Numerous leukocyte differentiation antigens act as important markers for research, diagnosis, triage and eventually treatment targets for hematopoietic malignancies. V‑set and transmembrane domain‑containing 1 (VSTM1) was identified by immunogenomic analysis as a potential leukocyte differentia
PMID 25351446

Inhaled Corticosteroids Increase Siglec-5/14 Expression in Sputum Cells of COPD Patients.

Wielgat P1, Mroz RM, Stasiak-Barmuta A, Szepiel P, Chyczewska E, Braszko JJ, Holownia A.
Advances in experimental medicine and biology.Adv Exp Med Biol.2015;839:1-5. doi: 10.1007/5584_2014_51.
Recent studies show that several Siglec receptors, such as Siglec-8 and Siglec-14, may be important therapeutic targets in asthma and COPD. Siglecs are a family of lectins belonging to the immunoglobulin superfamily and recognize sialic acid residues of glycoproteins. Most of Siglecs have intracellu
PMID 25252903

Ligation of human Fc receptor like-2 by monoclonal antibodies down-regulates B-cell receptor-mediated signalling.

Shabani M1, Bayat AA, Jeddi-Tehrani M, Rabbani H, Hojjat-Farsangi M, Ulivieri C, Amirghofran Z, Baldari CT, Shokri F.
Immunology.Immunology.2014 Nov;143(3):341-53. doi: 10.1111/imm.12311.
B-cell antigen receptor (BCR) signalling and its regulation through negative and positive regulators are critical for balancing B-cell response and function. Human Fc receptor like-2 (FCRL2), a member of the newly identified FCRL family, could influence B-cell signalling due to possession of both im
PMID 24797767

Japanese Journal

抑制性レセプター,Siglec-8のヒト末梢血培養由来マスト細胞における発現とその機能 : アレルギー疾患に対する新しい創薬の可能性を秘めて(<特集>医学研究のUP-TO-DATE)

順天堂医学 54(1), 2-9, 2008-03
NAID 110007125196

抑制性レセプター, Siglec-8のヒト末梢血培養由来マスト細胞における発現とその機能:--アレルギー疾患に対する新しい創薬の可能性を秘めて--

順天堂医学 54(1), 2-9, 2008
NAID 130004716442

Differential contribution of the immunoreceptor tyrosine-based inhibitory motifs of human leukocyte-associated Ig-like receptor-1 to inhibitory function and phosphatase recruitment