WordNet

immunological disorder in which some part of the bodys immune system is inadequate and resistance to infectious diseases is reduced
incapable of developing an immune response following exposure to an antigen; "immunodeficient rodents"
bring disorder to (同)disarray
a physical condition in which there is a disturbance of normal functioning; "the doctor prescribed some medicine for the disorder"; "everyone gets stomach upsets from time to time" (同)upset
a disturbance of the peace or of public order
secure against; "immune from taxation as long as he resided in Bermuda"; "immune from criminal prosecution"
a person who is immune to a particular infection
relating to or conferring immunity (to disease or infection) (同)resistant
(usually followed by `to'
relating to the condition of immunity; "the immune system"
not arranged in order (同)unordered

PrepTutorEJDIC

〈U〉『無秩序』,混乱,乱雑(confusion) / 《しばしば複数形で》(社会的・政治的な)粉争,騒動 / 〈C〉(肉体的・精神的な)不調,異常,障害 / …‘の'秩序を乱す / 〈心身〉‘に'異常を起こさせる
免疫の / 《補語にのみ用いて》(影響・攻撃・義務・税などを)免れている《+『against』(『from, to』)+『名』》

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2013/10/11 23:00:33」(JST)

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An immune disorder is a dysfunction of the immune system. These disorders can be characterized in several different ways:

By the component(s) of the immune system affected
By whether the immune system is overactive or underactive
By whether the condition is congenital or acquired

According to the International Union of Immunological Societies, more than 150 primary immunodeficiency diseases (PIDs) have been characterized.^[1] However, the number of acquired immunodeficiencies exceeds the number of PIDs.^[2]

It has been suggested that most people have at least one primary immunodeficiency.^[3] Due to redundancies in the immune system, though, many of these are never detected.

List of some autoimmune disorders[edit]

Main article: autoimmune disorders

Lupus
Scleroderma
Certain types of hemolytic anemia
Vasculitis
Type one diabetes
Graves disease
Rheumatoid arthritis
Multiple sclerosis
Goodpasture's syndrome
Pernicious anemia
Some types of myopathy

Immunodeficiencies[edit]

Main article: immunodeficiency

Primary immune deficiency diseases are those caused by inherited genetic mutations. Secondary or acquired immune deficiencies are caused by something outside the body such as a virus or immune suppressing drugs.^[4]

Primary immune diseases are at risk to an increased susceptibility to, and often recurrent ear infections, pneumonia, bronchitis, sinusitis or skin infections. Immunodeficient patients may less frequently develop abscesses of their internal organs, autoimmune or rheumatologic and gastrointestinal problems.^[5]

Primary immune deficiencies

Severe combined immunodeficiency (SCID)
DiGeorge syndrome
Hyperimmunoglobulin E syndrome (also known as Job’s Syndrome)
Common variable immunodeficiency (CVID): B-cell levels are normal in circulation but with decreased production of IgG throughout the years, so it is the only primary immune disorder that presents onset in the late teens years.
Chronic granulomatous disease (CGD): a deficiency in NADPH oxidase enzyme, which causes failure to generate oxygen radicals. Classical recurrent infection from catalase positive bacteria and fungi.
Wiskott-Aldrich syndrome (WAS)
Autoimmune lymphoproliferative syndrome (ALPS)
Hyper IgM syndrome: X-linked disorder that causes a deficiency in the production of CD40 ligand on activated T-cells. This increases the production and release of IgM into circulation. The B-cell and T-cell numbers are within normal limits. Increased susceptibility to extracellular bacteria and opportunistic infections.
Leukocyte adhesion deficiency (LAD)
NF-κB Essential Modifier (NEMO) Mutations
Selective immunoglobulin A deficiency: the most common defect of the humoral immunity, characterized by a deficiency of IgA. Produces repeating sino-pulmonary and gastrointestinal infections.
X-linked agammaglobulinemia (XLA; also known as Bruton type agammaglobulinemia): characterized by a deficiency in tyrosine kinase enzyme that blocks B-cell maturation in the bone marrow. No B-cells are produced to circulation and thus, there are no immunoglobulin classes, although there tends to be a normal cell-mediated immunity.
X-linked lymphoproliferative disease (XLP)
Ataxia-telangiectasia

Secondary immune deficiencies

AIDS

Allergies[edit]

Main article: allergy

An allergy is an abnormal immune reaction to a harmless antigen.

Seasonal allergy
Mastocytosis
Perennial allergy
Anaphylaxis
Food allergy
Allergic rhinitis^[6]
Atopic dermatitis

References[edit]

^ Geha RS, Notarangelo LD, Casanova JL, et al. (October 2007). "Primary immunodeficiency diseases: an update from the International Union of Immunological Societies Primary Immunodeficiency Diseases Classification Committee". J. Allergy Clin. Immunol. 120 (4): 776–94. doi:10.1016/j.jaci.2007.08.053. PMC 2601718. PMID 17952897.
^ Kumar A, Teuber SS, Gershwin ME (2006). "Current perspectives on primary immunodeficiency diseases". Clin. Dev. Immunol. 13 (2–4): 223–59. doi:10.1080/17402520600800705. PMC 2270780. PMID 17162365.
^ Casanova JL, Abel L (August 2007). "Primary immunodeficiencies: a field in its infancy". Science 317 (5838): 617–9. doi:10.1126/science.1142963. PMID 17673650.
^ "Primary Immune Deficiency Diseases". Department of Health and Human Services: National Institutes of Health. Retrieved 31 August 2011.
^ "Primary Immunodeficiency FAQ". INFO4PI. Retrieved 31 August 2011.
^ http://www.merckmanuals.com/home/immune_disorders.html

External links[edit]

Immune disorder at the Open Directory Project

UpToDate Contents

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1. 感染症を繰り返す小児に対するアプローチ approach to the child with recurrent infections
2. 特異的抗体欠損 specific antibody deficiency
3. 慢性肉芽腫性疾患：病因、臨床症状、および診断 chronic granulomatous disease pathogenesis clinical manifestations and diagnosis
4. Recognition of immunodeficiency in the newborn period
5. Eosinophil biology and causes of eosinophilia

Japanese Journal

Regulation of intestinal inflammation through interaction of intestinal environmental factors and innate immune cells

,
Inflammation and Regeneration 35(1), 028-041, 2015
… The intestinal immune system can distinguish between symbiotic bacteria and pathogens, and activates pro-inflammatory responses against pathogenic bacteria for host defense while remaining unresponsive to the beneficial microbes and dietary antigens. … Inflammatory bowel disease is a chronic inflammatory disorder caused by alteration of several factors, such as host genetics, commensal bacteria and diet-derived compounds and metabolites. …
NAID 130004943875

ITPの病態と治療の進歩

柏木浩和,冨山佳昭
臨床血液 56(2), 177-184, 2015
ITPは免疫的機序により血小板破壊と血小板産生障害をきたす自己免疫疾患である。最近の研究により主たる自己抗体である抗GPIIb/IIIa抗体のエピトープの解析，標的分子によるITP病態の違い，更にITPの発症・慢性化に関与する免疫異常としてT細胞異常，特に制御性T細胞の重要性など，その病態に関する理解が進んできている。ITP治療はステロイドおよび脾臓摘出術無効例に対してトロンボポエチン(TPO)受 …
NAID 130004920706

化膿性脊椎炎および脊髄硬膜外膿瘍を伴った咽後膿瘍例

大野慶子,木村百合香
耳鼻咽喉科臨床 108(2), 133-138, 2015
… However, the morbidity and mortality rate are high in immune-compromised patients or when diagnosis and treatment are delayed. … An 83-year-old man presented to the emergency department of our hospital with disorder of consciousness (Japan coma scale I-2), weakness of the limbs, and a 4-day history of neck pain. …
NAID 130004827510

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リンク元	「immune disease」「immunologic disease」「immune system disease」「immunological disease」「免疫異常」
拡張検索	「autoimmune disorders of the nervous system」
関連記事	「disorder」「immune」