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In the idiopathic inflammatory myopathies (IIM), do reactive oxygen species (ROS) contribute to muscle weakness?

Lightfoot AP1, McArdle A1, Jackson MJ1, Cooper RG1.
Annals of the rheumatic diseases.Ann Rheum Dis.2015 Jul;74(7):1340-6. doi: 10.1136/annrheumdis-2014-207172. Epub 2015 Apr 28.
The idiopathic inflammatory myopathies (IIMs) are a group of rare autoimmune disorders, collectively known as myositis. Affected patients present with proximal muscle weakness, which usually improves following treatment with immunosuppressants, but often incompletely so, thus many patients remain we
PMID 26063809

Oguma J1, Ozawa S.
Kyobu geka. The Japanese journal of thoracic surgery.Kyobu Geka.2015 Jul;68(8):701-5.
Esophageal rupture is a rare emergency disorder. The leakage of gastric contents and foods can cause severe mediastinitis and pyothorax, occasionally resulting in the development of systemic sepsis and shock within hours. Iatrogenic injury to the esophagus is the most frequent cause of esophageal ru
PMID 26197919

Streptococcus pneumoniae triggers progression of pulmonary fibrosis through pneumolysin.

Knippenberg S1, Ueberberg B1, Maus R1, Bohling J1, Ding N1, Tort Tarres M1, Hoymann HG2, Jonigk D3, Izykowski N3, Paton JC4, Ogunniyi AD4, Lindig S5, Bauer M5, Welte T6, Seeger W7, Guenther A7, Sisson TH8, Gauldie J9, Kolb M9, Maus UA10.
Thorax.Thorax.2015 Jul;70(7):636-46. doi: 10.1136/thoraxjnl-2014-206420. Epub 2015 May 11.
RATIONALE: Respiratory tract infections are common in patients suffering from pulmonary fibrosis. The interplay between bacterial infection and fibrosis is characterised poorly.OBJECTIVES: To assess the effect of Gram-positive bacterial infection on fibrosis exacerbation in mice.METHODS: Fibrosis pr
PMID 25964315

Republication: Two premature neonates of congenital syphilis with severe clinical manifestations

Akahira-Azuma Moe,Kubota Mai,Hosokawa Shinichi,Kaneshige Masao,Yasuda Noriko,Sato Noriko,Matsushita Takeji
Tropical Medicine and Health advpub(0), 2015
… Patient 1 (gestational age 31 weeks, birth weight 1423 g) had disseminated idiopathic coagulation (DIC) while Patient 2 (gestational age 34 weeks and 6 days, birth weight 2299 g) had refractory syphilitic meningitis. … Each neonate was initially treated with ampicillin and cefotaxime for early bacterial sepsis/meningitis that coexisted with CS. …
NAID 130005076137

松谷毅,野村務,萩原信敏,牧野浩司,丸山弘,宮下正夫,内田英二
日本腹部救急医学会雑誌 35(1), 061-065, 2015
（目的）当科における食道破裂・穿孔症例の診断，治療と転帰を検討する。（対象）2003～2013年までの食道破裂・穿孔15例（特発性4例，医原性11例）を対象とした。（結果）特発性の縦隔内限局型2例は保存的治療を，胸腔内穿破型2例は手術療法を行った。食道アカラシアおよび食道狭窄のバルーン拡張術，内視鏡的逆行性胆管膵管造影用の内視鏡ファイバー，咽頭部通過用のガイドチューブ，食道癌に対する粘膜剥離術など …
NAID 130005069724

藤田昌久,石川文彦,釜田茂幸,山田千寿,兼子耕
日本大腸肛門病学会雑誌 68(3), 157-162, 2015
2003年1月から2012年12月までに，2施設で手術を施行し，病理組織学的に診断された特発性大腸穿孔26例を対象とした．年齢は59歳から90歳，平均76.8歳であり，性別は男性11例，女性15例であった．慢性的な便秘を12例に，便秘との関連が疑われる併存疾患を12例に，排便など発症の誘因となる動作を11例に認め，88％に便秘や排便と関連する患者因子を認めた．死亡率は27％であり，生存例と死亡例で …
NAID 130004902118