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1. 小児や青年の肥満の定義、疫学、病因definition epidemiology and etiology of obesity in children and adolescents [show details]
…progressive severe obesity, which is particularly difficult to treat In the pediatric age group, hypothalamic obesity most often arises after surgical treatment for craniopharyngioma, and usually is associated …
2. 成人の肥満：疫学および危険因子obesity in adults etiology and risk factors [show details]
…medications across a spectrum of diseases, can alter body weight and even lead to obesity Hypothalamic obesity is a rare syndrome in humans that can be regularly produced in animals by injury to the ventromedial …
3. 小児における先天性中枢性低換気症候群および睡眠関連低換気症のその他の原因congenital central hypoventilation syndrome and other causes of sleep related hypoventilation in children [show details]
4. 頭蓋咽頭腫craniopharyngioma [show details]
…include: Neurocognitive deficits, particularly among patients with hypothalamic involvement ; Hypothalamic obesity Sleep disorders and a disrupted circadian rhythm ; Behavioral problems ; Most patients…
5. 癌の治療中や治療後の小児に起きる睡眠障害sleep disorders during and after cancer in children [show details]

English Journal

Genetic screening for MC4R gene identifies three novel mutations associated with severe familiar obesity in a cohort of Spanish individuals.

Gimeno-Ferrer F, Albuquerque D, García Banacloy A, Guzmán Luján C, Vidal Garcia C, Marcaida Benito G, Sánchez Juan C, Bruna Esteban M, Rodríguez-López R.
Gene. 2019 Jul;704()74-79.
MC4R gene is a hypothalamic satiety control mediator in which mutations cause a monogenic form of obesity. The aim of this study was to perform a genetic screening to identify variations in the entire region of MC4R gene. A total of 236 unrelated and severely obese patients (BMI ≥ 40 kg/m) w
PMID 30981838

Multi-system reproductive metabolic disorder: significance for the pathogenesis and therapy of polycystic ovary syndrome (PCOS).

Li Y, Chen C, Ma Y, Xiao J, Luo G, Li Y, Wu D.
Life sciences. 2019 Jul;228()167-175.
Polycystic ovary syndrome (PCOS), a multisystem disease, is a major reason for female infertility around the world. It is no longer considered simply as a disease of ovary. Now researchers growing awareness of the multisystem features of this disease. PCOS has a higher relationship with metabolic di
PMID 31029778

Protopanaxadiol alleviates obesity in high-fat diet-fed mice via activation of energy-sensing neuron in the paraventricular nucleus of hypothalamus.

Liu C, Li H, Zhou Z, Li J, Chen H, Liu Y, Huang C, Fan S.
Biochemical and biophysical research communications. 2019 Jun;513(4)1092-1099.
Obesity is one of the most important health problems worldwide. Panax ginseng has been reported to exert anti-obesity effect. However, the active constituents and the underlying mechanism remained uncertain. This study uncovered the anti-obesity effect of protopanaxadiol (PPD) and its potential mech
PMID 31010683

The effects of chronic testosterone administration on body weight, food intake, and fat weight were age-dependent

Iwasa Takeshi,Matsuzaki Toshiya,Mayila Yiliyasi,Yano Kiyohito,Irahara Minoru
Steroids 127, 18-23, 2017-09-08
… In addition, although the administration of testosterone increased the serum leptin level, it did not alter hypothalamic neuropeptide Y mRNA expression in middle-aged rats. … Thus, testosterone might induce hypothalamic leptin resistance, which could lead to fat accumulation in older individuals. … Testosterone might disrupt the mechanisms that protect against adiposity and hyperphagia and represent a risk factor for excessive body weight and obesity, especially in older females. …
NAID 120006535068

Quercetin Protects Obesity-Induced Hypothalamic Inflammation by Reducing Microglia-Mediated Inflammatory Responses via HO-1 Induction

Yang Jihyeon,Kim Chu-Sook,Tu Thai,Kim Min-Seon,Goto Tsuyoshi,Kawada Teruo,Choi Myung-Sook,Park Taesun,Sung Mi-Kyung,Yun Jong,Choe Suck-Young,Lee Jee,Joe Yeonsoo,Choi Hye-Seon,Back Sung,Chung Hun,Yu Rina
Nutrients 9(7), 2017-06-23
… Obesity-induced hypothalamic inflammation is characterized by activation of microglia, which are resident macrophages of the central nervous system, and is implicated in the derangement of energy homeostasis, metabolic complications, and neurodegenerative diseases. …
NAID 120006333889