hypertrophy of the liver

肝腫大

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• 1. 大腸癌肝転移に対する肝切除術hepatic resection for colorectal cancer liver metastasis [show details]
  …remnant liver hypertrophies. Portal vein embolization can be performed after the first operation to promote the extent of liver hypertrophy . If there is sufficient hypertrophy to prevent liver failure …
• 2. アルコール性脂肪性肝炎およびアルコール性肝硬変の臨床症状および診断clinical manifestations and diagnosis of alcoholic fatty liver disease and alcoholic cirrhosis [show details]
  … findings in patients with cirrhosis may include atrophy of the right lobe of the liver, hypertrophy of the caudate lobe, hypertrophy of the lateral segment of the left lobe, parenchymal nodularity, attenuation …
• 3. 切除可能大腸癌の肝転移のマネージメントmanagement of potentially resectable colorectal cancer liver metastases [show details]
  …while awaiting hypertrophy as this practice significantly reduces rates of hepatic tumor progression and does not inhibit liver hypertrophy. If there is sufficient hypertrophy to prevent liver failure at …
• 4. 術前門脈塞栓術preoperative portal vein embolization [show details]
  … assessment of the liver volume using computed tomography or magnetic resonance imaging is performed before PVE and repeated four weeks after PVE to assess the extent of liver hypertrophy prior to undertaking …
• 5. 肝肥大：鑑別診断および評価hepatomegaly differential diagnosis and evaluation [show details]
  … lobe of the liver can also be elongated and is described as a "beaver-tailed liver." In this case, a large left hepatic lobe may be confused with hepatomegaly or the left lobe hypertrophy that can be seen …

English Journal

• SWELL signalling in adipocytes: can fat 'feel' fat?

• Gunasekar SK, Xie L, Sah R.
• Adipocyte. 2019 Dec;8(1)223-228.
• Obesity is becoming a global epidemic, predisposing to Type 2 diabetes, cardiovascular disease, fatty liver disease, pulmonary disease, osteoarthritis and cancer. Therefore, understanding the biology of adipocyte expansion in response to overnutrition is critical to devising strategies to treat obes
• PMID 31112068

• Right ventricular pressure overload alters cardiac lipid composition.

• Koop AMC, Hagdorn QAJ, Bossers GPL, van Leusden T, Gerding A, van Weeghel M, Vaz FM, Koonen DPY, Silljé HHW, Berger RMF, Bartelds B.
• International journal of cardiology. 2019 Jul;287()96-105.
• Right ventricular (RV) failure due to pressure load is an important determinant of clinical outcome in pulmonary hypertension, congenital heart disease and left ventricular failure. The last decades it has become clear that metabolic dysregulation is associated with the development of RV-failure. Ho
• PMID 31003793

• Fibroblast growth factor 21 protects the heart from angiotensin II-induced cardiac hypertrophy and dysfunction via SIRT1.

• Li S, Zhu Z, Xue M, Yi X, Liang J, Niu C, Chen G, Shen Y, Zhang H, Zheng J, Zhao C, Liang Y, Cong W, Wang Y, Jin L.
• Biochimica et biophysica acta. Molecular basis of disease. 2019 Jun;1865(6)1241-1252.
• This study investigated the mechanism through which fibroblast growth factor 21 (FGF21) protects against angiotensin II (Ang II)-induced cardiac hypertrophy and dysfunction. Male silent information regulator 1 (SIRT1) flox/flox and cardiomyocyte-specific inducible SIRT1 knockout mice (SIRT1-iKO) wer
• PMID 30677512

Japanese Journal

• Lack of Association of a Single Nucleotide Polymorphism （rs1053874）in the DNase I Gene With Plural Tissue Weight

• TAKINAMI Yoshikazu,FUJIHARA Junko,Kimura Kaori,INOUE Ken,KOMINATO Yoshihiko,Yamada Kazuo,Takeshita Haruo
• Shimane Journal of
• … Background: We have found the association of single nucleotide polymorphism （SNP） rs6180 in the growthhormone receptor （GHR） gene with plural tissue weight. …
• NAID 120006601927

• Blood Pressure-Independent Effect of Olmesartan on Albuminuria in Mice Overexpressing Renin:Its Beneficial Role in the ACE2/Ang (1-7)/Mas Axis and NADPH Oxidase Expression

• Ichikawa Hiroaki,Tomita Hirofumi,Narita Ikuyo,Narita Masato,Tanno Tomohiro,Yokono Yoshikazu,Kimura Yoshihiro,Tanaka Makoto,Osanai Tomohiro,Okumura Ken
• International Heart Journal 59(6), 1445-1453, 2018
• … <p>Enhanced renin-angiotensin activity contributes to hypertension, albuminuria, and glomerular hypertrophy. … The angiotensin (Ang)-converting enzyme (ACE) 2/Ang (1-7)/Mas axis pathway acts against Ang II type 1 receptor (AT1R) signaling. …
• NAID 130007522207

• The first clinical cases of <i>Haemoproteus</i> infection in a snowy owl (<i>Bubo scandiacus</i>) and a goshawk (<i>Accipiter gentilis</i>) at a zoo in the Republic of Korea

• LEE Seung-Hun,KWAK Dongmi,KIM Kyoo-Tae
• Ｔｈｅ
• … <p>This study reports two clinical cases of avian haemosporidian infection caused by a <i>Haemoproteus</i> … The snowy owl died after presenting with anorexia, depression and lethargy. …
• NAID 130007432152

Related Links

• Top 5 Causes of Liver Hypertrophy And How To Detox ...

They will be able to keep a check on your liver and make sure that it is working the way it is supposed to. After years of research in patients with liver hypertrophy, doctors have comprised a list of symptoms that may indicate an ...

• Liver, Hepatocyte - Hypertrophy - Nonneoplastic Lesion Atlas

comment: Hepatocyte hypertrophy is a form of cytologic alteration that is diagnosed based on an observable increased size of hepatocytes compared with concurrent control liver. It is most readily apparent when it has ...

• Liver Hypertrophy: A Review of Adaptive (Adverse and Non ...

Preclinical toxicity studies have demonstrated that exposure of laboratory animals to liver enzyme inducers during preclinical safety assessment results in a signature of toxicological changes characterized by an increase in liver ...

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★リンクテーブル★

リンク元	「肝腫大」
関連記事	「live」「thing」「liver」

「肝腫大」

　　[★]

英

hepatomegaly, hypertrophy of the liver

同

肝肥大

関

肝臓

概念

• 肝臓がびまん性あるいは局所性に腫大した状態。

症状

• ほぼ無症状。
• 著名に腫大すれば、周囲臓器圧迫により腹満感や息苦しさを訴えることがある。

診察

• 健常者でも約20%に右肋骨弓下に肝を触れる
• 右肋骨弓下に2横指触れれば肝腫大と診断可能

頻度

• 右心不全：100%
• 一過性肝腫脹：高頻度(80%以上)急性心不全、急性ウイルス感染症、薬物性肝障害。
• 持続的肝腫大：高頻度(80%以上)脂肪肝、慢性肝炎、肝硬変。原発性胆汁性肝硬変、ヘモクロマトーシス、Wilson病、巨大肝嚢胞、巨大肝血管腫。

原因

• 脈管：特発性門脈圧亢進症、肝静脈閉塞(バッド・キアリ症候群)、右心不全
• 蓄積：脂肪肝、ヘモクロマトーシス、アミロイドーシス、ウィルソン病、糖原病、
• 炎症：急性ウイルス性肝炎、慢性肝炎、肝硬変、アルコール性肝障害、薬物性肝障害、結核、サルコイドーシス、種々のウイルス感染、寄生虫感染、膠原病
• 胆汁鬱滞：肝内胆汁うっ滞、肝外胆汁うっ滞、原発性硬化性胆管炎
• 腫瘍浸潤：白血病、悪性リンパ腫、多発性骨髄腫、骨髄増殖性疾患
• 肝腫瘍：肝細胞癌、胆管細胞癌、肝芽腫、肝嚢胞、肝海綿状血管腫、転移性肝癌

診断

• 血液検査で肝機能、アルブミン、肝炎ウイルス、ANA、ANA、EBV、CMVを評価
• 腹部超音波検査、腹部造影CT、MRCPが有用
• 腫瘍を疑う場合にはPIVKA II, AFP, CEA, CA19-9

鑑別診断

DIF

	V	I	N	D	I	C	A	T	E
	vascular	infection	neoplasm	degenerative	intoxication	congenital	autoimmune	trauma	endocrine
間質		ウイルス性肝炎	肝細胞癌	脂肪肝	アルコール中毒	嚢胞性疾患	ルポイド肝炎	肝挫傷	甲状腺亢進症
		伝染性単核球症	転移性肝癌		四塩化炭素薬	過誤腫		肝裂傷
		アメーバー症			薬物
支持組織			肝臓肉腫			ゴーシェ病	結節性動脈周囲炎
						溶血性貧血	骨髄異形成
静脈	肝静脈血栓症	門脈炎
動脈	肝動脈結紮							肝動脈結紮
リンパ管			ホジキンリンパ腫
胆管		胆管炎	十二指腸乳頭腫		母乳による胆汁濃縮	胆道閉鎖症		胆石	胆石
			十二指腸乳頭部癌
			膵癌
細胆管		細菌性胆管炎	胆管癌		チアジド系利尿薬	デュビン・ジョンソン症候群			妊娠
					避妊用ピル

「live」

　　[★]

[liv]

• vt.
• vi.

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[laiv]

• adj.

同

LAIV

　 　 　 　 　 　 　 　 　 　 　 　

「thing」

　　[★] 　 　 　 　 　 　 　 　 　 　 　 　

「liver」

　　[★] 肝臓