WordNet
- on the surface; "surface materials of the moon"
- the outer boundary of an artifact or a material layer constituting or resembling such a boundary; "there is a special cleaner for these surfaces"; "the cloth had a pattern of red dots on a white surface"
- the outermost level of the land or sea; "earthquakes originate far below the surface"; "three quarters of the Earths surface is covered by water" (同)Earth''s surface
- a superficial aspect as opposed to the real nature of something; "it was not what it appeared to be on the surface"
- the extended two-dimensional outer boundary of a three-dimensional object; "they skimmed over the surface of the water"; "a brush small enough to clean every dental surface"; "the sun has no distinct surface"
- come to the surface (同)come_up, rise up, rise
- sing with closed lips; "She hummed a melody"
- a humming noise; "the hum of distant traffic" (同)humming
- be noisy with activity; "This office is buzzing with activity" (同)buzz, seethe
- sound with a monotonous hum (同)thrum
- make a low continuous sound; "The refrigerator is humming"
- small room in which a monk or nun lives (同)cubicle
- a device that delivers an electric current as the result of a chemical reaction (同)electric cell
- a room where a prisoner is kept (同)jail cell, prison cell
- (biology) the basic structural and functional unit of all organisms; they may exist as independent units of life (as in monads) or may form colonies or tissues as in higher plants and animals
- any small compartment; "the cells of a honeycomb"
- a small unit serving as part of or as the nucleus of a larger political movement (同)cadre
- relating to a person; "the experiment was conducted on 6 monkeys and 2 human subjects"
- characteristic of humanity; "human nature"
- having human form or attributes as opposed to those of animals or divine beings; "human beings"; "the human body"; "human kindness"; "human frailty"
- of or involving the ovaries; "ovarian cancer"
PrepTutorEJDIC
- (物の)表面,外面;水面 / 《比喩的に》『うわべ』,見かけ / 『表面(水面)の,』表面(水面)に関する / 《比喩的に》『うわべだけの,』見かけだけの / 陸(水)上輸送の / (沈んでいたものが)表面に浮上する;《話》《おどけて》(寝ていた人が)起きる / (…で)…‘に'表面をつける,〈道路〉‘を'舗装する《+名+with+名》
- 〈ハチ・機械などが〉『ブンブンいう』,ブーンと鳴る / 『鼻歌を歌う』,ハミングスル / (ちゅうちょ・当惑で)ふむふむいう / 《話》〈雰囲気・事業などが〉活気がある,活発に動く;(…で)活気づく《+『with』+『名』》 / …‘を'『ハミングで歌う』,鼻歌を歌って…‘を'(ある状熊に)する / (ハチ・機械などの)『ブンブン』[『うなる音』];鼻歌 / (雑踏などの)ガヤガヤ]いう音],騒音 / ふ‐む,う‐ん(ちゅうちょ・当惑・黙考・疑惑・不快などの声)
- (刑務所の)『独房』;(修道院の)小さい独居室 / (ミツバチの)みつ房,巣穴 / 小さい部屋 / 『細胞』 / 電池 / 花粉室 / (共産党などの)細胞
- (動物・神に対して)『人間の』,人の / 『人間らいし』,人間的な,人情味のある / 〈C〉《複数形》(動物に怠して)人間(human being) / 〈U〉《the human》人類
- 卵巣の / 子房(しぼう)の
UpToDate Contents
全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.
- 1. 卵巣癌、卵管癌、および腹膜癌：病期分類および初期外科的マネージメント cancer of the ovary fallopian tube and peritoneum staging and initial surgical management
- 2. 卵巣の悪性胚細胞腫瘍の治療 treatment of malignant germ cell tumors of the ovary
- 3. 卵巣胚細胞腫瘍：病理学、臨床症状、および診断 ovarian germ cell tumors pathology clinical manifestations and diagnosis
- 4. 妊娠中における付属器腫瘤 adnexal mass in pregnancy
- 5. 上皮性卵巣癌、卵管癌、および腹膜癌：臨床的特徴および診断 epithelial carcinoma of the ovary fallopian tube and peritoneum clinical features and diagnosis
English Journal
- Methylation of OPCML promoter in ovarian cancer tissues predicts poor patient survival.
- Zhou F, Tao G, Chen X, Xie W, Liu M, Cao X.AbstractAbstract Background: Ovarian cancer is a lethal gynecological malignancy largely due to the lack of biomarkers for early detection and treatment options. Opioid binding protein/cell adhesion molecule-like gene (OPCML) has a tumor-suppressor function in ovarian cancer, and epigenetic inactivation of OPCML induces oncogenic transformation of human ovarian surface epithelial cells. Methods: This study investigated OPCML promoter methylation levels in ovarian cancer tissues. A total of 30 normal ovarian, 85 benign ovarian tumor, and 102 ovarian cancer tissues were subjected to quantitative methylation-specific PCR analysis of OPCML methylation. Four ovarian cancer cell lines were cultured and treated with the DNA demethylation agent 5-aza-2'-deoxycytidine (5-AZA) for restoring OPCML expression. Results: The data showed that 80 of 102 (78.4%) ovarian cancer tissues and 28 of 85 (32.9%) benign ovarian tumors had a methylated OPCML gene promoter. In contrast, there was no OPCML gene promoter methylation in any of the 30 normal ovarian samples. OPCML promoter methylation was significantly associated with an older age of the patients (p=0.022), an advanced pathological stage of ovarian cancer (p=0.023), and poor overall survival of ovarian cancer patients (p<0.001). Multivariate analysis data showed that pathological stage, age, and OPCML promoter methylation were all independent factors to predict overall survival of patients. Furthermore, 5-AZA was able to restore expression of OPCML mRNA and protein in ovarian cancer cell lines. Conclusions: These data indicate that detection of OPCML gene promoter methylation could be a useful biomarker for predicting the prognosis of ovarian cancer patients and disease progression.
- Clinical chemistry and laboratory medicine : CCLM / FESCC.Clin Chem Lab Med.2014 May 1;52(5):735-42. doi: 10.1515/cclm-2013-0736.
- Abstract Background: Ovarian cancer is a lethal gynecological malignancy largely due to the lack of biomarkers for early detection and treatment options. Opioid binding protein/cell adhesion molecule-like gene (OPCML) has a tumor-suppressor function in ovarian cancer, and epigenetic inactivation of
- PMID 24327526
- MUC16 mucin (CA125) attenuates TRAIL-induced apoptosis by decreasing TRAIL receptor R2 expression and increasing c-FLIP expression.
- Matte I, Lane D, Boivin M, Rancourt C, Piché A.AbstractBACKGROUND: MUC16 (CA125) is a large transmembrane mucin protein (> 200 kDa) aberrantly expressed in approximately 80% of human epithelial ovarian cancers (EOC). MUC16 expression in EOC cells is associated with increased tumorigenesis and inhibiton of genotoxic drug-induced apoptosis. However, the mechanism by which MUC16 mediates these effects is unknown. In the present study, we investigated the mechanisms by which MUC16 attenuates TRAIL-induced apoptosis.
- BMC cancer.BMC Cancer.2014 Apr 1;14(1):234. [Epub ahead of print]
- BACKGROUND: MUC16 (CA125) is a large transmembrane mucin protein (> 200 kDa) aberrantly expressed in approximately 80% of human epithelial ovarian cancers (EOC). MUC16 expression in EOC cells is associated with increased tumorigenesis and inhibiton of genotoxic drug-induced apoptosis. However, th
- PMID 24690311
- Cystatin B is a progression marker of human epithelial ovarian tumors mediated by the TGF-β signaling pathway.
- Wang X1, Gui L2, Zhang Y2, Zhang J1, Shi J1, Xu G1.Author information 1Center Laboratory, Jinshan Hospital, Fudan University, Shanghai 201508, P.R. China.2Department of Pathology, Jinshan Hospital, Fudan University, Shanghai 201508, P.R. China.AbstractAdvanced ovarian cancer is a devastating disease. Gaining biomarkers of early detection during ovarian tumorigenesis may lead to earlier diagnosis and better therapeutic strategies. Cystatin B (CSTB) functions as an inhibitor to suppress intracellular cysteine proteases and has been implicated in several types of cancers. The present study explored the expression of CSTB in human ovarian tumors, to investigate CSTB expression associated with clinicopathological features, and to examine the effect of transforming growth factor-β (TGF-β), which plays a key role in ovarian tumorigenesis, on CSTB expression in ovarian cancer cells. The ovarian tissue samples from 33 patients were retrieved. The expression of CSTB in ovarian tissue was examined by immunohistochemistry. We found that CSTB was over-expressed in human ovarian surface epithelial tumors, including serous, mucinous and clear cell tumors. The immunoreactive staining of CSTB was strong in borderline and malignant tumors, weak in benign tumors, and negative in normal tissue counterparts, but was not correlated with the clinicopathological features of patients with ovarian tumors, such as age, histological types, tumor size, lymph node metastasis and clinical stages. The CSTB at mRNA and protein levels in two types of epithelial ovarian cancer cells, OVCAR-3 and SK-OV-3, was decreased after TGF-β1 treatment detected by quantitative PCR and western blot analysis, respectively. The inhibitory effect of TGF-β1 on CSTB expression was abolished in the presence of SB-431542, a TGF-β type I receptor kinase inhibitor. Our data suggest that CSTB is tumor tissue-specific and overexpressed in ovarian borderline and malignant tumors. The increased CSTB expression in ovarian tissue represents tumor progression and is dysregulated by the TGF-β signaling pathway. CSTB may become a novel diagnostic intracellular biomarker for the early detection of ovarian cancer.
- International journal of oncology.Int J Oncol.2014 Apr;44(4):1099-106. doi: 10.3892/ijo.2014.2261. Epub 2014 Jan 21.
- Advanced ovarian cancer is a devastating disease. Gaining biomarkers of early detection during ovarian tumorigenesis may lead to earlier diagnosis and better therapeutic strategies. Cystatin B (CSTB) functions as an inhibitor to suppress intracellular cysteine proteases and has been implicated in se
- PMID 24452274
Japanese Journal
- 難治性卵巣癌の浸潤・転移に関わる分子をターゲットとした新規治療法の開発(シンポジウム2(腫瘍) 難治性卵巣癌の克服を目指して,第66回日本産科婦人科学会学術講演会講演要旨)
- 日本産科婦人科學會雜誌 66(11), 2771-2776, 2014-11-01
- NAID 110009872636
- 薬剤運搬に適した腫瘍標的化抗体のスクリーニング法と創薬シーズ開発
- YAKUGAKU ZASSHI 133(9), 931-938, 2013
- NAID 130003361992
- (3)難治性卵巣がんに対する新たな分子標的治療の開発を目指した基礎的研究 : 基礎から臨床へ(<特集>第61回学術講演会シンポジウム3「卵巣癌の新たな治療戦略-基礎から,そして臨床から-」)
- 日本産科婦人科學會雜誌 61(11), 2042-2053, 2009-11-01
- NAID 110007467575
Related Links
- Human Ovarian Surface Epithelial Cells,7310,Primary Cells,Human,Ovarian Cell System,Epithelial Cells, ScienCell Research Laboratories : Human primary cells, Animal cells, Cell culture medium and primary cell derived DNA, RNA and ...
- BACKGROUND: The ovarian surface epithelium (OSE) is a modified mesothelium that gives rise to most human ovarian carcinomas. In culture, OSE cells tend to assume atypical morphologies that make it difficult to accurately identify normal ...
Related Pictures
★リンクテーブル★
| リンク元 | 「HOSE cell」「ヒト卵巣表層上皮細胞」 |
| 関連記事 | 「human」「surface」「epithelial」「epithelial cell」「ovarian」 |
「HOSE cell」
「ヒト卵巣表層上皮細胞」
「human」
- n.
- adj.
- ヒトの、ヒト型の
「surface」
- n.
「epithelial」
- 上皮の、上皮系の、上皮性の、上皮型の
「epithelial cell」
「ovarian」
- adj.
- 卵巣の、(植物)子房の
- 関
- ovary