WordNet

markedly different from an accepted norm; "aberrant behavior"; "deviant ideas" (同)deviant, deviate
one whose behavior departs substantially from the norm of a group
state in which the conditions of life are extremely bad as from deprivation or oppression or terror
a work of fiction describing an imaginary place where life is extremely bad because of deprivation or oppression or terror
abnormal position of a part or organ (especially at the time of birth)
(of biological species or speciation) occurring in areas isolated geographically from one another

PrepTutorEJDIC

正道からはずれた,常軌を逸した;異常な

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2013/06/29 18:23:18」(JST)

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1. ヘモグロビンの酸素親和性に関する遺伝性疾患 genetic disorders of hemoglobin oxygen affinity
2. 咽喉頭逆流 laryngopharyngeal reflux

English Journal

T-quaternary structure of oxy human adult hemoglobin in the presence of two allosteric effectors, L35 and IHP.

Kanaori K, Tajiri Y, Tsuneshige A, Ishigami I, Ogura T, Tajima K, Neya S, Yonetani T.SourceDepartment of Biomolecular Engineering, Kyoto Institute of Technology, Matsugasaki, Sakyo-ku, Kyoto 606-8585, Japan.
Biochimica et biophysica acta.Biochim Biophys Acta.2011 Oct;1807(10):1253-61. Epub 2011 Jun 15.
The cooperative O(2)-binding of hemoglobin (Hb) have been assumed to correlate to change in the quaternary structures of Hb: T(deoxy)- and R(oxy)-quaternary structures, having low and high O(2)-affinities, respectively. Heterotropic allosteric effectors have been shown to interact not only with deox
PMID 21703224

Hemoglobin allostery: Variations on the theme.

Bellelli A, Brunori M.AbstractThe two-state allosteric model of Monod, Wyman and Changeux (1965) offers a simple and elegant, yet very powerful and comprehensive, description of the functional behavior of hemoglobin. Although the extensive body of structural and functional information available is by-and-large consistent with this conceptual framework, some discrepancies between theory and experiment have been extensively discussed and considered to demand modifications of the original hypothesis. More recently the role of tertiary structural changes has been re-analyzed leading to extended kinetic models or indicating that powerful heterotropic effectors may be of paramount importance in controlling the function of human hemoglobin. The aim of this review is to analyze, and possibly reconcile, some discrepancies. We always felt that by looking at hemoglobins other than human HbA, the relative role of tertiary and quaternary allosteric effects may be better understood. The model systems illustrated below are the different hemoglobins from trout's blood, since they are characterized by the most striking variability of heterotropic effects, ranging from totally absent to very extreme with dominant contributions of tertiary effects. This article is part of a Special Issue entitled: Allosteric cooperativity in respiratory proteins.
Biochimica et biophysica acta.Biochim Biophys Acta.2011 Oct;1807(10):1262-72. Epub 2011 May 3.
The two-state allosteric model of Monod, Wyman and Changeux (1965) offers a simple and elegant, yet very powerful and comprehensive, description of the functional behavior of hemoglobin. Although the extensive body of structural and functional information available is by-and-large consistent with th
PMID 21565157

Japanese Journal

1P102 T quaternary state of oxy haemoglobin in the presence of heterotropic effectors(Heme proteins,The 48th Annual Meeting of the Biophysical Society of Japan)

Kanaori Kenji,Tajiri Yusuke,Tsuneshige Antonio,Yonetani Takashi
生物物理 50(SUPPLEMENT_2), S37, 2010-08-15
NAID 110008102338

Bifidobacterium bifidumの乳酸脱水素酵素

露木あかね,飯野久和,松本孝
學苑 806, 50-55, 2007-12
Bifidobacterium bifidum DSM20456からNAD^+依存性の乳酸脱水素酵素(LDH)を電気泳動的にほぼ均一な状態に精製した。この酵素はピルビン酸からの乳酸生成のみならず,乳酸からピルビン酸への酸化反応においても,その活性発現にフルクトース1,6-二リン酸を要求したが,それぞれの反応における酵素の基質に対する親和性は,ピルビン酸の方が乳酸よりも2,000倍近く高かった。
NAID 110007054746

Related Pictures

★リンクテーブル★

リンク元	「aberrant」「ectopia」「異所」「異所性」「ectopic」
拡張検索	「heterotropically」

「aberrant」

　　[★]

ab 'away, from' + errare 'to stray' -> aberrant 'wandering away'

adj.

正道をはずれた、軌道を逸した。あやまった。(生)異常型の。(医)異所性の、迷入性の

Autosomal dominant dRTA results from mutations involving the chloride-bicarbonate exchanger AE1, the gateway for bicarbonate exit into the blood. Anion exchange by the mutant AE1 is normal, but aberrant targeting of AE1 from the basal to apical plasma membrane is believed to cause bicarbonate loss into the urine instead of recovery.(HIM.1085)