English Journal

Genetically engineered pigs and target-specific immunomodulation provide significant graft survival and hope for clinical cardiac xenotransplantation.

Mohiuddin MM1, Singh AK2, Corcoran PC2, Hoyt RF3, Thomas ML 3rd4, Ayares D5, Horvath KA2.
The Journal of thoracic and cardiovascular surgery.J Thorac Cardiovasc Surg.2014 Sep;148(3):1106-13; discussion 1113-4. doi: 10.1016/j.jtcvs.2014.06.002. Epub 2014 Jun 6.
OBJECTIVES: Cardiac transplantation and available mechanical alternatives are the only possible solutions for end-stage cardiac disease. Unfortunately, because of the limited supply of human organs, xenotransplantation may be the ideal method to overcome this shortage. We have recently seen signific
PMID 24998698

Spermatogonial stem cell enrichment using simple grafting of testis and in vitro cultivation.

Lim JJ1, Seol DW2, Choi KH1, Shin DH1, Kim HJ1, Song SH3, Lee DR4.
Scientific reports.Sci Rep.2014 Aug 1;4:5923. doi: 10.1038/srep05923.
Enrichment of spermatogonial stem cells (SSCs) from the mammalian adult testis faces several limitations owing to their relatively low numbers among many types of advanced germ cells and somatic cells. The aim of the present study was to improve the isolation efficiency of SSCs using a simple tissue
PMID 25080919

Heterotropic modulation of selectin affinity by allosteric antibodies affects leukocyte rolling.

Riese SB1, Kuehne C, Tedder TF, Hallmann R, Hohenester E, Buscher K.
Journal of immunology (Baltimore, Md. : 1950).J Immunol.2014 Feb 15;192(4):1862-9. doi: 10.4049/jimmunol.1302147. Epub 2014 Jan 15.
Selectins are a family of adhesion receptors designed for efficient leukocyte tethering to the endothelium under shear. As a key property to resist premature bond disruption, selectin adhesiveness is enhanced by tensile forces that promote the conversion of a bent into an extended conformation of th
PMID 24431230