hepatitis B immune globulin

同

HBIG

WordNet

1. secure against; "immune from taxation as long as he resided in Bermuda"; "immune from criminal prosecution"
2. a person who is immune to a particular infection
3. relating to or conferring immunity (to disease or infection) (同)resistant
4. (usually followed by `to'
5. relating to the condition of immunity; "the immune system"
6. the 2nd letter of the Roman alphabet (同)b
7. the blood group whose red cells carry the B antigen (同)type_B, group B
8. a family of proteins found in blood and milk and muscle and in plant seed
9. inflammation of the liver caused by a virus or a toxin

PrepTutorEJDIC

1. 免疫の / 《補語にのみ用いて》(影響・攻撃・義務・税などを)免れている《+『against』(『from, to』)+『名』》
2. グロブリン(動植物組織内の純蛋白(たんぱく)質の総称)
3. 肝[臓]炎

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/02/10 23:18:23」(JST)

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[Wiki en表示]

Hepatitis B immune globulin

Clinical data
AHFS/Drugs.com	monograph
Pregnancy cat.	C (US)
Legal status	?
Routes	intramuscular injection
Identifiers
ATC code	J06BB04
Chemical data
Formula	?
N (what is this?)  (verify)

Hepatitis B immune globulin (HBIG) is a human immune globulin that is used to prevent the development of hepatitis B.

Preparation

HBIG is prepared from the plasma of donors who have high antibody levels of the hepatitis B surface antigen. It is extracted from the Cohn Fraction II. During the process, viruses are deactivated, and in the final steps, solvents used in the preparation are removed. The preparation is tested for absence of HIV, HCV, herpes virus, and reovirus.

Indications

HBIG is indicated as a postexposure prophylaxis for people at risk to develop hepatitis B because they have been recently exposed to body fluids of individuals who have hepatitis B. This includes babies of mothers with hepatitis B, sexual partners, healthcare workers, police and fire workers, and morticians. It provides a temporarily induced immunity by the transfer of immunoglobulins.

The medication is given as an intramuscular injection. Side effects include allergic reactions, back pain, general feeling of discomfort, headaches, muscle pain, nausea, and pain or bleeding at the injection site. Allergy to human immune globulin is a contraindication. HIV has never been transmitted by HBIG. As with all blood-derived products, the transmission of prions is possible as a residual risk.

Concomitant vaccination

HBIG should be given within 14 days of exposure to the hepatitis B virus. The half-life of HBIG is about 3 weeks. In lieu of a booster administration of HBIG, a hepatitis B vaccination is initiated at the time of the initial HBIG administration, thus providing long term protection.

HBIG is classified as pregnancy category C substance by the U.S. Food and Drug Administration.

Brand names

• Bayhep B
• HepaGam B
• HyperHEP B
• Nabi-HB
• Nabi-HB NovaPlus

References

See also

• Needlestick injury

UpToDate Contents

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

• 1. 医療従事者におけるB型肝炎ウイルスおよびC型肝炎ウイルス感染の予防 prevention of hepatitis b virus and hepatitis c virus infection among healthcare providers
• 2. 慢性B型肝炎ウイルス感染に対する肝移植 liver transplantation for chronic hepatitis b virus infection
• 3. 乳児、小児、青年へのB型肝炎ウイルス予防接種 hepatitis b virus immunization in infants children and adolescents
• 4. B型肝炎と妊娠 hepatitis b and pregnancy
• 5. 肝炎ウイルスと新生児：臨床症状および治療 hepatitis viruses and the newborn clinical manifestations and treatment

English Journal

• Antiviral therapy in chronic hepatitis B viral infection during pregnancy: A systematic review and meta-analysis.

• Brown RS Jr1, McMahon BJ2, Lok AS3, Wong JB4, Ahmed AT5,6, Mouchli MA7, Wang Z5,6, Prokop LJ8, Murad MH5,6,9, Mohammed K5,6,9.
• Hepatology (Baltimore, Md.).Hepatology.2016 Jan;63(1):319-33. doi: 10.1002/hep.28302. Epub 2015 Nov 13.
• Perinatal or mother-to-child transmission (MTCT) of hepatitis B virus (HBV) remains the major risk factor for chronic HBV infection worldwide. In addition to hepatitis B immune globulin and vaccination, oral antiviral therapies in highly viremic mothers can further decrease MTCT of HBV. We conducted
• PMID 26565396

• A human monoclonal antibody against small envelope protein of hepatitis B virus with potent neutralization effect.

• Wang W1, Sun L2, Li T1, Ma Y3, Li J4, Liu Y2, Li M1, Wang L1, Li C2, Xie Y1, Wen Y1, Liang M2, Chen L1, Tong S1.
• mAbs.MAbs.2015 Dec 29:0. [Epub ahead of print]
• Hepatitis B virus (HBV) produces large (L), middle (M), and small (S) envelope proteins, alternatively referred to as hepatitis B surface antigen (HBsAg). Currently, yeast-derived S protein serves as the preventive vaccine, while hepatitis B immune globulin (HBIG) concentrated from pooled plasma of
• PMID 26713590

• Limited benefit of hepatitis B immunoglobulin prophylaxis in children of hepatitis Be antigen negative mothers.

• Lee LY1,2, Aw MM1,2, Saw S3, Rauff M4, Tong PY4, Lee GH5,6.
• Singapore medical journal.Singapore Med J.2015 Dec 29. doi: 10.11622/smedj.2015194. [Epub ahead of print]
• INTRODUCTION: Since 2006, Singapore has adopted the universal hepatitis B immune globulin (HBIg) policy for all infants delivered of hepatitis B surface antigen (HBsAg) positive mothers to receive HBIg, irrespective of maternal hepatitis Be antigen (HBeAg) status. However, the benefits of HBIg for s
• PMID 26778725

Japanese Journal

• B型肝炎ワクチン(HBワクチン)と抗HBs人免疫グロブリン(HBIG)の適応と効果--我が国におけるB型肝炎ウイルス(HBV)感染予防対策の現状と課題 (新時代のウイルス性肝炎学--基礎・臨床研究の進歩) -- (B型肝炎ウイルス感染とその予防対策)

• 小方 則夫,舟田 久,青柳 豊
• 日本臨床 69(-) (999), 408-416, 2011-05-00
• NAID 40018838508

• HBV垂直感染のリスク

• 花岡 正智,山口 晃史,久保 隆彦,名取 道也
• 日本周産期・新生児医学会雑誌 = Journal of Japan Society of Perinatal and Neonatal Medicine 45(4), 1345-1349, 2009-12-20
• NAID 10029091293

• Characterization of Liver Injury Associated with Hypersensitive Skin Reactions Induced by Trichloroethylene in the Guinea Pig Maximization Test

• Tang Xiaojiang,Que Bingling,Song Xiangrong [他],LI Senhua,YANG Xiaojun,WANG Hailan,HUANG Hanlin,KAMIJIMA Michihiro,NAKAJIMA Tamie,LIN Yongcheng,LI Laiyu
• Journal of occupational health 50(2), 114-121, 2008-03-00
• … Trichloroethylene (TCE) can induce non-dose-related hepatitis, possibly classified as delayed-type hypersensitivity (immune-mediated hepatitis), as well as dose-related toxic liver injury. … However, the difference in pathophysiology between the two kinds of hepatitis remains unknown. … The guinea pig maximization test (GPMT) was also carried out as a model of immune-mediated liver injury, in which the total TCE dosage was below 340 mg/kg. …
• NAID 110006680528

Related Links

• Hepatitis B immune globulin - Wikipedia, the free encyclopedia

N (what is this?) (verify). Hepatitis B immune globulin (HBIG) is a human immune globulin that is used to prevent the development of hepatitis B. Contents. 1 Preparation; 2 Indications; 3 Concomitant vaccination; 4 Brand names; 5 References ...

• Hepatitis B Immune Globulin (Intramuscular Route, Intravenous ...

1 Jul 2012 ... Hepatitis B immune globulin (Human) injection is used to prevent hepatitis B from occurring again in HBsAg-positive liver transplant patients who have had liver transplants. This medicine also helps keep you from getting sick ...

Related Pictures

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★リンクテーブル★

リンク元	「BAYHEP B」「H-BIG」「HYPERHEP」
関連記事	「B」「immune」「globuli」「immune globulin」

「BAYHEP B」

　　[★]

関

hepatitis B immune globulin

「H-BIG」

　　[★]

同

hepatitis B immune globulin

「HYPERHEP」

　　[★]

関

hepatitis B immune globulin

「B」

　　[★]

• 気管分岐部下緑
• 補体のalternative pathwayに関わる蛋白質

• Mg2+存在下でC3, B, Dが反応してC3bBbとなり、これがC3転換酵素(C3bBb)あるいはC5転換酵素(C3bBb3b)を形成する。これらはP(properdin)と結合して活性化し、それぞれC3、C5を活性化する

　 　

「immune」

　　[★]

• adj.

• 免疫の、免疫性の

関

immunisation、immunise、immunity、immunization、immunize、immuno、immunologic

　 　 　 　 　 　

「globuli」

　　[★]

• np.

• 小球

関

globule、globulus、spherule

「immune globulin」

　　[★] 免疫グロブリン Ig immunoglobulins Igs