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- 1. 肝グリコーゲン合成酵素欠損症（糖原病0型） liver glycogen synthase deficiency glycogen storage disease 0
- 2. 低アルドステロン症（4型RTA）の病因、診断、および治療 etiology diagnosis and treatment of hypoaldosteronism type 4 rta
- 3. エキノカンジンの薬理学 pharmacology of echinocandins
- 4. 新生児におけるカンジダ感染の治療 treatment of candida infection in neonates
- 5. 新生児における特殊な真菌感染症 unusual fungal infections in the neonate
English Journal
- Modulation of Alternaria infectoria Cell Wall Chitin and Glucan Synthesis by Cell Wall Synthase Inhibitors.
- Fernandes C1, Anjos J, Walker LA, Silva BM, Cortes L, Mota M, Munro CA, Gow NA, Gonçalves T.Author information 1CNC-Center for Neurosciences and Cell Biology, University of Coimbra, Coimbra, Portugal.AbstractThe present work reports the effects of caspofungin, a β-1,3-glucan synthase inhibitor, and nikkomycin Z, an inhibitor of chitin synthases, on two strains of Alternaria infectoria, a melanized fungus involved in opportunistic human infections and respiratory allergies. One of the strains tested, IMF006, bore phenotypic traits that conferred advantages in resisting antifungal treatment. First, the resting cell wall chitin content was higher and in response to caspofungin, the chitin level remained constant. In the other strain, IMF001, the chitin content increased upon caspofungin treatment to values similar to basal IMF006 levels. Moreover, upon caspofungin treatment, the FKS1 gene was upregulated in IMF006 and downregulated in IMF001. In addition, the resting β-glucan content was also different in both strains, with higher levels in IMF001 than in IMF006. However, this did not provide any advantage with respect to echinocandin resistance. We identified eight different chitin synthase genes and studied relative gene expression when the fungus was exposed to the antifungals under study. In both strains, exposure to caspofungin and nikkomycin Z led to modulation of the expression of class V and VII chitin synthase genes, suggesting its importance in the robustness of A. infectoria. The pattern of A. infectoria phagocytosis and activation of murine macrophages by spores was not affected by caspofungin. Monotherapy with nikkomycin Z and caspofungin provided only fungistatic inhibition, while a combination of both led to fungal cell lysis, revealing a strong synergistic action between the chitin synthase inhibitor and the β-glucan synthase inhibitor against this fungus.
- Antimicrobial agents and chemotherapy.Antimicrob Agents Chemother.2014 May;58(5):2894-904. doi: 10.1128/AAC.02647-13. Epub 2014 Mar 10.
- The present work reports the effects of caspofungin, a β-1,3-glucan synthase inhibitor, and nikkomycin Z, an inhibitor of chitin synthases, on two strains of Alternaria infectoria, a melanized fungus involved in opportunistic human infections and respiratory allergies. One of the strains tested, IM
- PMID 24614372
- Breakthrough Candidemia Due to Multidrug-Resistant Candida glabrata during Prophylaxis with a Low Dose of Micafungin.
- Bizerra FC1, Jimenez-Ortigosa C, Souza AC, Breda GL, Queiroz-Telles F, Perlin DS, Colombo AL.Author information 1Laboratório Especial de Micologia, Disciplina de Infectologia, Universidade Federal de São Paulo, São Paulo, Brazil.AbstractWe identified a case of breakthrough candidemia in a 25-year-old patient receiving micafungin prophylaxis (50 mg/day). Five Candida glabrata isolates were obtained from blood cultures and were classified as multidrug-resistant isolates, since all of them exhibited high MICs for echinocandin and azole drugs. A mutation (S663F) in hot spot 1 of the FKS2 gene was found in all five isolates. This mutation yielded a 1,3-β-d-glucan synthase enzyme with highly reduced sensitivities to echinocandin drugs.
- Antimicrobial agents and chemotherapy.Antimicrob Agents Chemother.2014 Apr;58(4):2438-40. doi: 10.1128/AAC.02189-13. Epub 2014 Jan 27.
- We identified a case of breakthrough candidemia in a 25-year-old patient receiving micafungin prophylaxis (50 mg/day). Five Candida glabrata isolates were obtained from blood cultures and were classified as multidrug-resistant isolates, since all of them exhibited high MICs for echinocandin and azol
- PMID 24468776
- An immunomodulatory activity of micafungin in preclinical aspergillosis.
- Moretti S1, Bozza S, Massi-Benedetti C, Prezioso L, Rossetti E, Romani L, Aversa F, Pitzurra L.Author information 1Department of Experimental Medicine and Biochemical Science, University of Perugia, Polo Unico Sant'Andrea delle Fratte, 06132 Perugia, Italy.AbstractOBJECTIVES: Micafungin inhibits 1,3-β-d-glucan synthase and interferes with fungal cell wall synthesis. Clinically, micafungin has been shown to be efficacious for the treatment of invasive fungal infections. However, little is known about the immunomodulatory activity of micafungin in these infections.
- The Journal of antimicrobial chemotherapy.J Antimicrob Chemother.2014 Apr;69(4):1065-74. doi: 10.1093/jac/dkt457. Epub 2013 Nov 20.
- OBJECTIVES: Micafungin inhibits 1,3-β-d-glucan synthase and interferes with fungal cell wall synthesis. Clinically, micafungin has been shown to be efficacious for the treatment of invasive fungal infections. However, little is known about the immunomodulatory activity of micafungin in these infect
- PMID 24265229
Japanese Journal
- Binding Specificity of the Recombinant Cytoplasmic Domain of Cordyceps militaris β-1,3-Glucan Synthase Catalytic Subunit
- Ujita Minoru,Inoue Ryosuke,Makino Yusuke [他],KATSUNO Yosuke,OKUMURA Hiroki
- Bioscience, biotechnology, and biochemistry 75(1), 171-174, 2011-01-23
- … β-1,3-glucan synthase catalytic subunit Fks1 was expressed as a fusion protein with an N-terminal hexahistidine tag and glutathione <I>S</I>-transferase in an <I>Escherichia coli</I> … The recombinant cytoplasmic domain bound specifically to UDP-agarose and lichenan (β-glucan), but not to ADP-agarose, GDP-agarose, or other carbohydrates. …
- NAID 10027897161
- Structure of bacterial cellulose synthase subunit D octamer with four inner passageways
- Hu Song-Qing,Gao Yong-Gui,Tajima Kenji,Sunagawa Naoki,Zhou Yong,Kawano Shin,Fujiwara Takaaki,Yoda Takanori,Shimura Daisuke,Satoh Yasuharu,Munekata Masanobu,Tanaka Isao,Yao Min
- Proceedings of the National Academy of Sciences of the United States of America 107(42), 17957-17961, 2010-10-19
- … The cellulose synthesizing terminal complex consisting of subunits A, B, C, and D in Acetobacter xylinum spans the outer and inner cell membranes to synthesize and extrude glucan chains, which are assembled into sub-elementary fibrils and further into a ribbon. … The location of cellopentaoses in the complex structure suggests that four glucan chains are extruded individually through their own passageway along the dimer interface in a twisted manner. …
- NAID 120002911946
- 3P-1101 麹菌α-1,3グルカン合成酵素遺伝子破壊による細胞壁の分泌タカアミラーゼ吸着能(3a発酵生理学,発酵工学,一般講演,代謝生理学・発酵生産,伝統の技と先端科学技術の融合)
- 佐藤 宏樹,新谷 尚弘,五味 勝也
- 日本生物工学会大会講演要旨集 平成22年度, 83, 2010-09-25
- NAID 110008084657
Related Links
- This is the glycosyltransferase 48 family, which consists of various 1,3-beta- glucan synthase components including Gls1, Gls2 and Gls3 from yeast. 1,3-beta- glucan synthase (EC 2.4.1.34.) also known as callose synthase catalyses the ...
- ABSTRACT. The glucan synthase complex of the human pathogenic moldAspergillus fumigatus has been investigated. The genes encoding the putative catalytic subunit Fks1p and four Rho proteins ofA. fumigatus were cloned and ...
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★リンクテーブル★
| リンク元 | 「グルカン合成酵素」「グルカンシンターゼ」 |
| 関連記事 | 「synthase」「gluc」「glucan」 |
「グルカン合成酵素」
「グルカンシンターゼ」
「synthase」
- n.
「gluc」
「glucan」
- 同
- glucosan