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The nanoparticulation by octaarginine-modified liposome improves α-galactosylceramide-mediated antitumor therapy via systemic administration.

Nakamura T, Yamazaki D, Yamauchi J, Harashima H.SourceFaculty of Pharmaceutical Sciences, Hokkaido University, Kita 12 Nishi 6, Kita-ku, Sapporo, Hokkaido 060-0812, Japan.
Journal of controlled release : official journal of the Controlled Release Society.J Control Release.2013 Oct 28;171(2):216-24. doi: 10.1016/j.jconrel.2013.07.004. Epub 2013 Jul 13.
Alpha-galactosylceramide (αGC), a lipid antigen present on CD1d molecules, is predicted to have clinical applications as a new class of adjuvant, because αGC strongly activates natural killer T (NKT) cells which produce large amounts of IFN-γ. Here, we incorporated αGC into stearylated octaargin
PMID 23860186

Cholesterol and glycosphingolipids of human trabecular meshwork and aqueous humor: comparative profiles from control and glaucomatous donors.

Aribindi K, Guerra Y, Piqueras Mdel C, Banta JT, Lee RK, Bhattacharya SK.SourceBascom Palmer Eye Institute, University of Miami , Miami, FL , USA.
Current eye research.Curr Eye Res.2013 Oct;38(10):1017-26. doi: 10.3109/02713683.2013.803123. Epub 2013 Jun 21.
Abstract Purpose: To determine the differential profiles of cholesterol and glycosphingolipid species and their quantitative differences between control and glaucomatous aqueous humor (AQH) and the trabecular meshwork (TM) derived from human donors. Methods: Control TM and selected primary open angl
PMID 23790057

Opposing effects of prednisolone treatment on T/NKT Cell- and Hepatotoxin-Mediated hepatitis in mice.

Kwon HJ, Won YS, Park O, Feng D, Gao B.SourceLaboratory of Liver Diseases, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD, USA; College of Veterinary Medicine, Chungnam National University, Yuseong-gu, Daejeon, South Korea.
Hepatology (Baltimore, Md.).Hepatology.2013 Oct 1. doi: 10.1002/hep.26748. [Epub ahead of print]
Prednisolone is a corticosteroid that has been used to treat inflammatory liver diseases such as autoimmune hepatitis and alcoholic hepatitis. However, the results have been controversial, and how prednisolone affects liver disease progression remains unknown. In the current study we examined the ef
PMID 24115096

Activation of Natural Killer T Cells Ameliorates Postinfarct Cardiac Remodeling and Failure in Mice

Sobirin Mochamad Ali,Kinugawa Shintaro,Takahashi Masashige,Fukushima Arata,Homma Tsuneaki,Ono Taisuke,Hirabayashi Kagami,Suga Tadashi,Azalia Putri,Takada Shingo,Taniguchi Masaru,Nakayama Toshinori,Ishimori Naoki,Iwabuchi Kazuya,Tsutsui Hiroyuki
Circulation Research 111(8), 1037-1047, 2012-09-28
… Methods and Results: After creation of MI, mice received the injection of either α-galactosylceramide (αGC; …
NAID 120005228375

Activation of Invariant NKT Cells with Glycolipid Ligand α-Galactosylceramide Ameliorates Glucose-6-Phosphate Isomerase Peptide-Induced Arthritis

Horikoshi Masanobu,Goto Daisuke,Segawa Seiji,Yoshiga Yohei,Iwanami Keiichi,Inoue Asuka,Tanaka Yuki,Matsumoto Isao,Sumida Takayuki,後藤大輔,瀬川誠司,井上明日香,松本功,住田孝之
PLoS ONE 7(12), e51215, 2012-00-00
… ObjectiveInvariant natural killer T (iNKT) cells regulate collagen-induced arthritis (CIA) when activated by their potent glycolipid ligand, alpha-galactosylceramide (α-GalCer). …
NAID 120005246546

Sulfatides Inhibit Adhesion, Migration, and Invasion of Murine Melanoma B16F10 Cell Line in Vitro

Ozawa Hiroki,Sonoda Yoshiko,Kato Saori [他],Suzuki Erika,Matsuoka Ryotaro,Kanaya Takayuki,Kiuchi Fumiyuki,Hada Noriyasu,Kasahara Tadashi
Biological and Pharmaceutical Bulletin 35(11), 2054-2058, 2012
… Endogenous sulfatide, such as 3-sulfated galactosylceramide (3-sulfatide) has been reported to be involved in neuronal development and regulation of tumor cell metastasis. …
NAID 130001872262