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English Journal

Possible role of cortactin phosphorylation by protein kinase Cα in actin-bundle formation at growth cone.

Yamada H1, Kikuchi T1, Masumoto T2,3, Wei FY4, Abe T1, Takeda T1, Nishiki T2, Tomizawa K4, Watanabe M5, Matsui H2, Takei K1.
Biology of the cell / under the auspices of the European Cell Biology Organization.Biol Cell.2015 Jun 1. doi: 10.1111/boc.201500032. [Epub ahead of print]
BACKGROUND INFORMATION: Cortactin contributes to growth cone morphogenesis by forming with dynamin, ring-shaped complexes that mechanically bundle and stabilize F-actin. However, the regulatory mechanism of cortactin action is poorly understood.RESULTS: Immunofluorescence microscopy revealed that pr
PMID 26033110

Structure, Distribution, and Function of Neuronal/Synaptic Spinules and Related Invaginating Projections.

Petralia RS1, Wang YX, Mattson MP, Yao PJ.
Neuromolecular medicine.Neuromolecular Med.2015 May 26. [Epub ahead of print]
Neurons and especially their synapses often project long thin processes that can invaginate neighboring neuronal or glial cells. These "invaginating projections" can occur in almost any combination of postsynaptic, presynaptic, and glial processes. Invaginating projections provide a precise mechanis
PMID 26007200

Sakai T1, Jung HS2, Sato O1, Yamada M3, You DJ4, Ikebe R1, Ikebe M5.
The Journal of biological chemistry.J Biol Chem.2015 May 22. pii: jbc.M114.599365. [Epub ahead of print]
Human myosin VIIA (HM7A) is responsible for human Usher Syndrome (USH) type 1B, which causes hearing and visual loss of humans. Here, we studied the regulation of HM7A. The actin activated ATPase activity of full-length HM7A (HM7AFull) was lower than that of tail-truncated HM7A (HM7AΔTail). Deletio
PMID 26001786