estrogen receptor beta

エストロゲン受容体β、エストロゲンレセプターβ

関

ER-beta、ERbeta

WordNet

1. to remain unmolested, undisturbed, or uninterrupted -- used only in infinitive form; "let her be"
2. work in a specific place, with a specific subject, or in a specific function; "He is a herpetologist"; "She is our resident philosopher" (同)follow
3. have life, be alive; "Our great leader is no more"; "My grandfather lived until the end of war" (同)live
4. be identical to; be someone or something; "The president of the company is John Smith"; "This is my house"
5. happen, occur, take place; "I lost my wallet; this was during the visit to my parents house"; "There were two hundred people at his funeral"; "There was a lot of noise in the kitchen"
6. have the quality of being; (copula, used with an adjective or a predicate noun); "John is rich"; "This is not a good answer"
7. occupy a certain position or area; be somewhere; "Where is my umbrella?" "The toolshed is in the back"; "What is behind this behavior?"
8. spend or use time; "I may be an hour"
9. stake on the outcome of an issue; "I bet $100 on that new horse"; "She played all her money on the dark horse" (同)wager, play
10. the act of gambling; "he did it on a bet" (同)wager
11. maintain with or as if with a bet; "I bet she will be there!" (同)wager
12. second in order of importance; "the candidate, considered a beta male, was perceived to be unable to lead his party to victory"
13. the 2nd letter of the Greek alphabet
14. preliminary or testing stage of a software or hardware product; "a beta version"; "beta software"
15. a general term for female steroid sex hormones that are secreted by the ovary and responsible for typical female sexual characteristics (同)oestrogen
16. a cellular structure that is postulated to exist in order to mediate between a chemical agent that acts on nervous tissue and the physiological response

PrepTutorEJDIC

1. 《連結語として補語を伴なって…『である』,…だ,…です / 《位置・場所を表す語句を伴って》(…に)『ある』,いる(occupy a place or situation) / 〈物事が〉『存在する』,ある(exist);〈生物が〉生存する,生きている(live) / 行われる,起こる,発生する(take place, occur) / 存続する,そのままでいる(remain as before) / 《『be to』 do》 / …する予定である,…することになっている / …すべきだ / 《受動態の不定詞を伴って》…できる / 《命令》…するのだ / 《条件節に》…する意図がある / 《『if…were to』 do》…するとしたなら / 《『be』 do『ing』》《進行形》 / 《進行中の動作》…している,しつつある / 《近い未来》…しようとしている,するつもり / 《動作の反復》(いつも)…している / 《『be』+『他動詞の過去分詞』》《受動態》…される,されている / 《『be』+『自動詞の過去分詞』》《完了形》…した[状態にある]
2. 『かけ』・(…との)かけ《+『with』+『名』》 / かけた物(金) / かけの対象 / 〈金・物〉'を'『かける』 / (かけ事・ゲームなどで)〈人〉‘と'『かけをする』《+『名』〈人〉+『on』+『名』》 / (…に)『かける』《+『on』(『against』)+『名』(one's do『ing』)》
3. ベータ(ギリシア語アルファベットの第2文字;B,β;英語のB,b に遭当)
4. エストロゲン(動物の雌を発情させる卵胞ホルモン)(《英》oestrogen)
5. =sense organ / 受信装置

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2013/10/08 07:01:19」(JST)

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[Wiki en表示]

See also: Estrogen receptor

Estrogen receptor 2 (ER beta)
PDB rendering based on 1hj1.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 1L2J, 1NDE, 1QKM, 1U3Q, 1U3R, 1U3S, 1U9E, 1X76, 1X78, 1X7B, 1X7J, 1YY4, 1YYE, 1ZAF, 2FSZ, 2GIU, 2I0G, 2JJ3, 2NV7, 2QTU, 2YJD, 2YLY, 2Z4B, 3OLL, 3OLS, 3OMO, 3OMP, 3OMQ, 4J24, 4J26
Identifiers
Symbols	ESR2; ER-BETA; ESR-BETA; ESRB; ESTRB; Erb; NR3A2
External IDs	OMIM: 601663 MGI: 109392 HomoloGene: 1100 IUPHAR: NR3A2 ChEMBL: 242 GeneCards: ESR2 Gene
Gene Ontology Molecular function • core promoter sequence-specific DNA binding • DNA binding • sequence-specific DNA binding transcription factor activity • steroid hormone receptor activity • transcription coactivator activity • ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity • steroid binding • protein binding • zinc ion binding • enzyme binding • estrogen receptor activity • estrogen response element binding • receptor antagonist activity Cellular component • extracellular region • nucleus • nucleoplasm • mitochondrion Biological process • negative regulation of transcription from RNA polymerase II promoter • ovarian follicle development • neuron migration • regulation of transcription, DNA-dependent • transcription initiation from RNA polymerase II promoter • signal transduction • cell-cell signaling • brain development • gene expression • negative regulation of cell growth • intracellular estrogen receptor signaling pathway • positive regulation of apoptotic process • negative regulation of epithelial cell proliferation • positive regulation of sequence-specific DNA binding transcription factor activity • uterus development • vagina development • prostate gland epithelium morphogenesis • epithelial cell maturation involved in prostate gland development • negative regulation of androgen receptor signaling pathway • extracellular negative regulation of signal transduction Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	2100	13983
Ensembl	ENSG00000140009	ENSMUSG00000021055
UniProt	Q92731	O08537
RefSeq (mRNA)	NM_001040275	NM_010157
RefSeq (protein)	NP_001035365	NP_034287
Location (UCSC)	Chr 14: 64.55 – 64.8 Mb	Chr 12: 76.12 – 76.18 Mb
PubMed search	[1]	[2]

Estrogen receptor beta (ER-β), also known as NR3A2 (nuclear receptor subfamily 3, group A, member 2), is a nuclear receptor which is activated by the sex hormone estrogen. In humans, ER-β is encoded by the ESR2 gene.

Function

Estrogen receptor β is a member of the family of estrogen receptors and the superfamily of nuclear receptor transcription factors. The gene product contains an N-terminal DNA binding domain and C-terminal ligand binding domain and is localized to the nucleus, cytoplasm, and mitochondria. Upon binding to 17-β-estradiol or related ligands, the encoded protein forms homo-dimers or hetero-dimers with estrogen receptor α that interact with specific DNA sequences to activate transcription. Some isoforms dominantly inhibit the activity of other estrogen receptor family members. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been fully characterized.

ER-β may have anti-proliferative effects and therefore oppose the actions of ER-α in reproductive tissue. ER-β may also have an important role in adaptive function of the lung during pregnancy.

Estrogen receptor β is a potent tumor suppressor and plays a crucial role in many cancer types such as prostate cancer.

Tissue distribution

ER-β is expressed by many tissues including blood monocytes and tissue macrophages, colonic and pulmonary epithelial cells and in prostatic epithelium and in malignant counterparts of these tissues. Also, ER-β is found throughout the brain at different concentrations in different neuron clusters.

Interactions

Estrogen receptor beta has been shown to interact with:

• Estrogen receptor alpha
• NCOA3,
• NCOA6,
• Cyclin D1,
• MAD2L1,
• RBM39, and
• Src.

References

Further reading

• Pettersson K, Gustafsson JA (2001). "Role of estrogen receptor beta in estrogen action". Annu. Rev. Physiol. 63: 165–92. doi:10.1146/annurev.physiol.63.1.165. PMID 11181953. 
• Warner M, Saji S, Gustafsson JA (2004). "The normal and malignant mammary gland: a fresh look with ER beta onboard". Journal of Mammary Gland Biology and Neoplasia 5 (3): 289–94. doi:10.1023/A:1009598828267. PMID 14973391. 
• Saxon LK, Turner CH (2005). "Estrogen receptor beta: the antimechanostat?". Bone 36 (2): 185–92. doi:10.1016/j.bone.2004.08.003. PMID 15780944. 
• Halachmi S, Marden E, Martin G et al. (1994). "Estrogen receptor-associated proteins: possible mediators of hormone-induced transcription". Science 264 (5164): 1455–8. doi:10.1126/science.8197458. PMID 8197458. 
• Schwabe JW, Chapman L, Finch JT, Rhodes D (1993). "The crystal structure of the estrogen receptor DNA-binding domain bound to DNA: how receptors discriminate between their response elements". Cell 75 (3): 567–78. doi:10.1016/0092-8674(93)90390-C. PMID 8221895. 
• Chen H, Lin RJ, Schiltz RL et al. (1997). "Nuclear receptor coactivator ACTR is a novel histone acetyltransferase and forms a multimeric activation complex with P/CAF and CBP/p300". Cell 90 (3): 569–80. doi:10.1016/S0092-8674(00)80516-4. PMID 9267036. 
• Pace P, Taylor J, Suntharalingam S et al. (1997). "Human estrogen receptor beta binds DNA in a manner similar to and dimerizes with estrogen receptor alpha". J. Biol. Chem. 272 (41): 25832–8. doi:10.1074/jbc.272.41.25832. PMID 9325313. 
• Brandenberger AW, Tee MK, Lee JY et al. (1997). "Tissue distribution of estrogen receptors alpha (ER-alpha) and beta (ER-beta) mRNA in the midgestational human fetus". J. Clin. Endocrinol. Metab. 82 (10): 3509–12. doi:10.1210/jc.82.10.3509. PMID 9329394. 
• Enmark E, Pelto-Huikko M, Grandien K et al. (1998). "Human estrogen receptor beta-gene structure, chromosomal localization, and expression pattern". J. Clin. Endocrinol. Metab. 82 (12): 4258–65. doi:10.1210/jc.82.12.4258. PMID 9398750. 
• Vladusic EA, Hornby AE, Guerra-Vladusic FK, Lupu R (1998). "Expression of estrogen receptor beta messenger RNA variant in breast cancer". Cancer Res. 58 (2): 210–4. PMID 9443393. 
• Ogawa S, Inoue S, Watanabe T et al. (1998). "The complete primary structure of human estrogen receptor beta (hER beta) and its heterodimerization with ER alpha in vivo and in vitro". Biochem. Biophys. Res. Commun. 243 (1): 122–6. doi:10.1006/bbrc.1997.7893. PMID 9473491. 
• Alves SE, Lopez V, McEwen BS, Weiland NG (1998). "Differential colocalization of estrogen receptor β (ERβ) with oxytocin and vasopressin in the paraventricular and supraoptic nuclei of the female rat brain: An immunocytochemical study". Proc. Natl. Acad. Sci. U.S.A. 95 (6): 3281–6. doi:10.1073/pnas.95.6.3281. PMC 19733. PMID 9501254. 
• Brandenberger AW, Tee MK, Jaffe RB (1998). "Estrogen receptor alpha (ER-alpha) and beta (ER-beta) mRNAs in normal ovary, ovarian serous cystadenocarcinoma and ovarian cancer cell lines: down-regulation of ER-beta in neoplastic tissues". J. Clin. Endocrinol. Metab. 83 (3): 1025–8. doi:10.1210/jc.83.3.1025. PMID 9506768. 
• Moore JT, McKee DD, Slentz-Kesler K et al. (1998). "Cloning and characterization of human estrogen receptor beta isoforms". Biochem. Biophys. Res. Commun. 247 (1): 75–8. doi:10.1006/bbrc.1998.8738. PMID 9636657. 
• Ogawa S, Inoue S, Watanabe T et al. (1998). "Molecular cloning and characterization of human estrogen receptor betacx: a potential inhibitor ofestrogen action in human". Nucleic Acids Res. 26 (15): 3505–12. doi:10.1093/nar/26.15.3505. PMC 147730. PMID 9671811. 
• Lu B, Leygue E, Dotzlaw H et al. (1998). "Estrogen receptor-beta mRNA variants in human and murine tissues". Mol. Cell. Endocrinol. 138 (1–2): 199–203. doi:10.1016/S0303-7207(98)00050-1. PMID 9685228. 
• Seol W, Hanstein B, Brown M, Moore DD (1998). "Inhibition of estrogen receptor action by the orphan receptor SHP (short heterodimer partner)". Mol. Endocrinol. 12 (10): 1551–7. doi:10.1210/me.12.10.1551. PMID 9773978. 
• Hanstein B, Liu H, Yancisin MC, Brown M (1999). "Functional analysis of a novel estrogen receptor-beta isoform". Mol. Endocrinol. 13 (1): 129–37. doi:10.1210/me.13.1.129. PMID 9892018. 
• Vidal O, Kindblom LG, Ohlsson C (1999). "Expression and localization of estrogen receptor-beta in murine and human bone". J. Bone Miner. Res. 14 (6): 923–9. doi:10.1359/jbmr.1999.14.6.923. PMID 10352100. 

External links

• Estrogen Receptor beta at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

UpToDate Contents

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

• 1. 選択的エストロゲン受容体モジュレーターの作用機序 mechanisms of action of selective estrogen receptor modulators
• 2. 男性不妊症の原因 causes of male infertility
• 3. 限局性、誘発性外陰部痛（旧名：外陰部前庭炎）の臨床症状および診断 clinical manifestations and diagnosis of localized provoked vulvodynia formerly vulvar vestibulitis
• 4. 乳房の葉状腫瘍 phyllodes tumors of the breast
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English Journal

• Estrogen receptor-β protects against colitis-associated neoplasia in mice.

• Saleiro D, Murillo G, Benya RV, Bissonnette M, Hart J, Mehta RG.SourceCancer Biology Division, IIT Research Institute, Chicago, IL; Graduate Program in Areas of Basic and Applied Biology, University of Porto, 4150 Porto, Portugal.
• International journal of cancer. Journal international du cancer.Int J Cancer.2012 Dec 1;131(11):2553-61. doi: 10.1002/ijc.27578. Epub 2012 Apr 27.
• Estrogen receptor-beta (ERβ) has been suggested to exert anti-inflammatory and anti-tumorigenic effects in the colon, providing a translational potential to prevent and/or treat inflammatory bowel disease (IBD) and its progression to colitis-associated colorectal cancer (CAC). However, the specific
• PMID 22488198

• The high-mobility group A1-estrogen receptor β nuclear interaction is impaired in human testicular seminomas.

• Esposito F, Boscia F, Gigantino V, Tornincasa M, Fusco A, Franco R, Chieffi P.SourceDipartimento di Medicina Sperimentale, II Università di Napoli, Via Costantinopoli, Naples, Italy.
• Journal of cellular physiology.J Cell Physiol.2012 Dec;227(12):3749-55. doi: 10.1002/jcp.24087.
• It is well established that estrogens participate in the control of normal spermatogenesis and endogenous or environmental estrogens are involved in pathological germ cell proliferation including testicular germ cell tumors. The effects of estrogen are now known to be mediated by estrogen receptor-�
• PMID 22392906

Japanese Journal

• An <i>in vivo</i> mouse model of primary dysmenorrhea

• Experimental Animals 64(3), 295-303, 2015
• NAID 130005091027

• An <i>in vivo</i> mouse model of primary dysmenorrhea

• Experimental Animals advpub(0), 2015
• NAID 130005066236

• 2C06-3 Relationship between estrogen receptor-beta gene polymorphism and carotid arterial thickness in Japanese women(The Proceedings of the 22nd Annual Meetings of Japan Society of Exercise and Sports Physiology July 19・20, (Okayama))

• Advances in exercise and sports physiology 20(4), 102, 2014-12
• NAID 110009878506

Related Links

• Estrogen receptor beta - Wikipedia, the free encyclopedia

Estrogen receptor beta (ER-β), also known as NR3A2 (nuclear receptor subfamily 3, group A, member 2), is a nuclear receptor which is activated by the sex hormone estrogen. In humans, ER-β is encoded by the ESR2 gene.

• Estrogen receptor - Wikipedia, the free encyclopedia

Estrogen receptor alpha and beta show significant overall sequence homology, and both are composed of five domains (listed from the N- to ... Different ligands may differ in their affinity for alpha and beta isoforms of the estrogen receptor: ...

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★リンクテーブル★

リンク元	「エストロゲン受容体β」「ERbeta」「エストロゲンレセプターβ」
関連記事	「beta」「estrogen receptor」「be」

「エストロゲン受容体β」

　　[★]

英

estrogen receptor beta、ERbeta、ER-beta

関

エストロゲンレセプターβ

「ERbeta」

　　[★]

• エストロゲン受容体β

関

ER-beta、estrogen receptor beta

「エストロゲンレセプターβ」

　　[★]

英

estrogen receptor beta

関

エストロゲン受容体β

「beta」

　　[★]

β、ベータ 　 　 　 　

「estrogen receptor」

　　[★] エストロゲン受容体 ER

「be」

　　[★]