Wild-type and specific mutant androgen receptor mediates transcription via 17β-estradiol in sex hormone-sensitive cancer cells.
Susa T1, Ikaga R, Kajitani T, Iizuka M, Okinaga H, Tamamori-Adachi M, Okazaki T.
Journal of cellular physiology.J Cell Physiol.2015 Jul;230(7):1594-606. doi: 10.1002/jcp.24906.
We previously encountered regulatory processes wherein dihydrotestosterone (DHT) exerted its inhibitory effect on parathyroid hormone-related protein (PTHrP) gene repression through the estrogen receptor (ER)α, but not the androgen receptor (AR), in breast cancer MCF-7 cells. Here, we investigated
Estrogen receptor α mediates the effects of notoginsenoside R1 on endotoxin-induced inflammatory and apoptotic responses in H9c2 cardiomyocytes.
Zhong L1, Zhou XL1, Liu YS1, Wang YM1, Ma F1, Guo BL1, Yan ZQ1, Zhang QY2.
Molecular medicine reports.Mol Med Rep.2015 Jul;12(1):119-26. doi: 10.3892/mmr.2015.3394. Epub 2015 Feb 27.
Estrogen receptors (ERs) are important for preventing endotoxin‑induced myocardial dysfunction. Therefore, plant‑derived phytoestrogens, which target ERs may also affect endotoxin‑induced toxicity in cardiomyocytes. Our previous study revealed that notoginsenoside‑R1 (NG‑R1), a predominant
Archives of oral biology.Arch Oral Biol.2015 Jun;60(6):818-24. doi: 10.1016/j.archoralbio.2015.02.007. Epub 2015 Feb 20.
OBJECTIVE: Temporomandibular joint (TMJ) disorders predominantly afflict women, suggesting that estrogen may play a role in the disease process. Defects in mechanical loading-induced TMJ remodelling are believed to be a major etiological factor in TMJ degenerative disease. Previously, we found that,
1. Trends Endocrinol Metab. 2010 Sep;21(9):545-52. doi: 10.1016/j.tem.2010.05.001. Epub 2010 Jun 18. ERbeta: recent understanding of estrogen signaling. Sugiyama N, Barros RP, Warner M, Gustafsson JA. Center for Nuclear ...