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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2013/03/18 08:56:06」(JST)

Epirizole (INN) is a nonsteroidal anti-inflammatory drug.

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English Journal

STAT3 and importins are novel mediators of early molecular and cellular responses in experimental duodenal ulceration.

Khomenko T1, Deng X, Ahluwalia A, Tarnawski A, Patel KN, Sandor Z, Szabo S.
Digestive diseases and sciences.Dig Dis Sci.2014 Feb;59(2):297-306. doi: 10.1007/s10620-013-2807-6. Epub 2014 Jan 3.
OBJECTIVES: Signal transducer and activator of transcription 3 (STAT3) is a transcription factor that directly upregulates VEGF, Ref-1, p21, and anti-apoptotic genes such as Bcl-xL. In this study, we hypothesized that STAT3 signaling is activated and provides a critical protective role that is requi
PMID 24385009

Chemical screen identifies FDA-approved drugs and target pathways that induce precocious pancreatic endocrine differentiation.

Rovira M1, Huang W, Yusuff S, Shim JS, Ferrante AA, Liu JO, Parsons MJ.
Proceedings of the National Academy of Sciences of the United States of America.Proc Natl Acad Sci U S A.2011 Nov 29;108(48):19264-9. doi: 10.1073/pnas.1113081108. Epub 2011 Nov 14.
Pancreatic β-cells are an essential source of insulin and their destruction because of autoimmunity causes type I diabetes. We conducted a chemical screen to identify compounds that would induce the differentiation of insulin-producing β-cells in vivo. To do this screen, we brought together the us
PMID 22084084

Gastric antisecretory and anti-ulcer effect of ME3407, a new benzimidazole derivative, in rats.

Tanaka J1, Iida H, Abe M, Yuda Y, Inoue S, Okabe S.
Arzneimittel-Forschung.Arzneimittelforschung.2004;54(4):221-9.
The effects of a new benzimidazole derivative, ME3407 (n-butyl-2-(thiazolo-[5,4-b]pyrid-2-yl) sulfinylacetate, CAS 133903-90-9), on gastric acid secretion and gastric and duodenal ulcers in rats were examined. ME3407, given orally, inhibited dose-dependently (0.3-30 mg/kg) the incidence of gastric l
PMID 15146935

Preparations of Agglomerated Crystals of Polymorphic Mixtures and a New Complex of Indomethacin-Epirizole by the Spherical Crystallization Technique.

リンク元	「エピリゾール」
拡張検索	「mepirizole」

Epirizole
Systematic (IUPAC) name
	4-methoxy-2-(5-methoxy-3-methylpyrazol-1-yl)-6-methylpyrimidine
Clinical data
AHFS/Drugs.com	International Drug Names
Pregnancy cat.	?
Legal status	℞ Prescription only
Routes	Oral
Identifiers
CAS number	18694-40-1
ATC code	None
PubChem	CID 3242
ChemSpider	3129
UNII	3B46O2FH8I
KEGG	D01394
Chemical data
Formula	C11H14N4O2
Mol. mass	234.25 g/mol
	SMILES n1c(OC)cc(nc1n2nc(cc2OC)C)C;
	InChI InChI=1S/C11H14N4O2/c1-7-5-9(16-3)13-11(12-7)15-10(17-4)6-8(2)14-15/h5-6H,1-4H3; Key:RHAXSHUQNIEUEY-UHFFFAOYSA-N ;
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