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a highly malignant neoplasm derived from striated muscle (同)rhabdosarcoma

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/12/28 11:07:42」(JST)

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Embryonal rhabdomyosarcoma (ERMS) is a rare histological form of cancer of connective tissue wherein the mesenchymally-derived malignant cells resemble the primitive developing skeletal muscle of the embryo. It is the most common soft tissue sarcoma occurring in children.^[1]

Classification

ERMS is the more common of two major subtypes of rhabdomyosarcoma, the other being alveolar rhabdomyosarcoma.

It has been informally classified as a "small round blue cell tumor"^[1] because of the characteristic microscopic appearance of its cells after histological staining with hematoxylin and eosin.

Prognosis and survival

The prognosis for rhabdomyosarcoma has improved greatly in recent decades, with over 70% of patients surviving for five years after diagnosis.^[2]

References

^ ^a ^b Masola V, Maran C, Tassone E, Zin A, Rosolen A, Onisto M (2009). "Heparanase activity in alveolar and embryonal rhabdomyosarcoma: implications for tumor invasion". BMC Cancer 9: 304. doi:10.1186/1471-2407-9-304. PMC 2743710. PMID 19715595.
^ Breitfeld PP, Meyer WH (August 2005). "Rhabdomyosarcoma: new windows of opportunity". Oncologist 10 (7): 518–27. doi:10.1634/theoncologist.10-7-518. PMID 16079319.

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1. 小児および思春期の横紋筋肉腫および未分化型肉腫：疫学、病理、および分子学的病因 rhabdomyosarcoma and undifferentiated sarcoma in childhood and adolescence epidemiology pathology and molecular pathogenesis
2. 小児および思春期の横紋筋肉腫および未分化型肉腫：治療 rhabdomyosarcoma and undifferentiated sarcoma in childhood and adolescence treatment
3. 小児および思春期の横紋筋肉腫および未分化型肉腫：臨床症状、診断的評価、および
病期分類 rhabdomyosarcoma and undifferentiated sarcoma in childhood and adolescence clinical presentation diagnostic evaluation and staging
4. 膣癌 vaginal cancer
5. 小児および思春期女性における膣出血の評価 evaluation of vaginal bleeding in children and adolescents

English Journal

Histopathological, immunohistochemical and molecular cytogenetic analysis of 21 spindle cell/sclerosing rhabdomyosarcomas.

Rekhi B1, Singhvi T.
APMIS : acta pathologica, microbiologica, et immunologica Scandinavica.APMIS.2014 Nov;122(11):1144-52. doi: 10.1111/apm.12272. Epub 2014 Apr 14.
Recently, spindle cell/sclerosing rhabdomyosarcoma (RMS) has been recognized as another distinct variant of a RMS. We evaluated clinicopathological features of 21 cases of spindle cell and sclerosing RMS and performed fluorescent in situ hybridization (FISH) testing in 10 (47.6%) tumours. Twenty-one
PMID 24730567

Preliminary Results of a Phase II Trial of Proton Radiotherapy for Pediatric Rhabdomyosarcoma.

Ladra MM1, Szymonifka JD1, Mahajan A1, Friedmann AM1, Yong Yeap B1, Goebel CP1, MacDonald SM1, Grosshans DR1, Rodriguez-Galindo C1, Marcus KJ1, Tarbell NJ1, Yock TI2.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology.J Clin Oncol.2014 Oct 20. pii: JCO.2014.56.1548. [Epub ahead of print]
PURPOSE: This prospective phase II study was designed to assess disease control and to describe acute and late adverse effects of treatment with proton radiotherapy in children with rhabdomyosarcoma (RMS).PATIENTS AND METHODS: Fifty-seven patients with localized RMS (age 21 years or younger) or meta
PMID 25332253

Japanese Journal

筋発生分化と横紋筋肉腫の発生病態 (特集個体発生と細胞分化の医学)

菊地顕,細井創
京都府立医科大学雑誌 122(6), 341-348, 2013-06
NAID 40019758685

膀胱全摘出術によって長期生存を認めた犬の横紋筋肉腫の1例

志賀大輔,三品美夏,青木大 [他],石井宏志,渡邊俊文
日本獣医師会雑誌 = Journal of the Japan Veterinary Medical Association 65(7), 525-529, 2012-07-20
1歳3カ月齢,未去勢のラブラドール・レトリバーが,血尿,頻尿を主訴に来院した。身体検査にて,下腹部に腫瘤を認め,超音波検査,X線膀胱造影検査を実施したところ,膀胱三角部全域にわたる膀胱腫瘤が確認されたため,膀胱全摘出術が実施された。摘出した膀胱は病理組織学的検査により胎児型横紋筋肉腫と診断された。手術後は,化学療法を1回実施したが,その後は飼い主の希望により経過観察とした。現在,術後約6年が経過し …
NAID 10030800987