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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2013/03/23 23:52:11」(JST)

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Denopamine (INN) is a cardiotonic drug which acts as a Beta-1 adrenergic receptor agonist.^[1] It is used in the treatment of angina^[2] and may also have potential uses in the treatment of congestive heart failure^[3] and for clearing pulmonary oedema.^[4]

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References

^ Ishide T. Denopamine, a selective beta1-receptor agonist and a new coronary vasodilator. Current Medical Research and Opinion. 2002;18(7):407-13. PMID 12487507
^ Nakajima D, Negoro N, Nakaboh A, Nakakoji T, Hoshiga M, Nariyama J, Ishihara T, Hanafusa T. Effectiveness of low dose denopamine, a beta1-adrenoceptor agonist, in a patient with vasospastic angina refractory to intensive medical treatment. International Journal of Cardiology. 2006 Apr 4;108(2):281-3. PMID 15913812
^ Nishio R, Matsumori A, Shioi T, Wang W, Yamada T, Ono K, Sasayama S. Denopamine, a beta1-adrenergic agonist, prolongs survival in a murine model of congestive heart failure induced by viral myocarditis: suppression of tumor necrosis factor-alpha production in the heart. Journal of the American College of Cardiology. 1998 Sep;32(3):808-15. doi:10.1016/S0735-1097(98)00314-3 PMID 9741531
^ Sakuma T, Hida M, Nambu Y, Osanai K, Toga H, Takahashi K, Ohya N, Inoue M, Watanabe Y. Beta1-adrenergic agonist is a potent stimulator of alveolar fluid clearance in hyperoxic rat lungs. Japanese Journal of Pharmacology. 2001 Feb;85(2):161-6. doi:10.1254/jjp.85.161 PMID 11286398

English Journal

Efficacy and limitations of oral inotropic agents for the treatment of chronic heart failure.

Murai K, Seino Y, Kimata N, Inami T, Murakami D, Abe J, Yodogawa K, Maruyama M, Takano M, Ohba T, Ibuki C, Mizuno K.SourceDepartment of Cardiology, Nippon Medical School.
International heart journal.Int Heart J.2013;54(2):75-81.
The heart failure guideline in Japan has stated the necessity of investigating the role of oral inotropic agents in patients with chronic heart failure (CHF), which are clinically available only in Japan. A total of 1,846 consecutive patients with heart failure (mean: 69.5 years old, 1,279 males) tr
PMID 23676366

The mechanism of beta-adrenergic preconditioning: roles for adenosine and ROS during triggering and mediation.

Salie R, Moolman JA, Lochner A.SourceDivision Medical Physiology, Department Biomedical Sciences, Faculty of Health Sciences, University of Stellenbosch, Tygerberg, Republic of South Africa.
Basic research in cardiology.Basic Res Cardiol.2012 Sep;107(5):281. doi: 10.1007/s00395-012-0281-5. Epub 2012 Jul 15.
The aim of this study was to investigate the mechanism of beta-adrenergic preconditioning (BPC). The roles of adenosine and its receptor subtypes, the generation of oxygen free radicals (ROS) and activation of the K(ATP) channels as well as the phosphoinositide-3-kinase (PI(3)K)/PKB/Akt and extracel
PMID 22797560

Japanese Journal

23) Denopamineにて治療継続がてきた低血圧を有する冠攣縮狭心症の一例(第91回日本循環器学会四国地方会)

横矢隆宏,佐藤真一,原田健
Circulation journal : official journal of the Japanese Circulation Society 72(Supplement_II), 908, 2008-04-20
NAID 110006913959

少量の denopamine が心室細動の抑制に有効であった Brugada 症候群の一例(第125回日本循環器学会東海地方会)

松岡宏治,藤井英太郎,大久保節也,笠井篤信,大道近也,内田文也,中野赳
Circulation journal : official journal of the Japanese Circulation Society 69(Supplement_III), 956, 2005-10-20
NAID 110004051170

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「デノパミン」

Denopamine
Systematic (IUPAC) name
	4-[(1S)-2-[2-(3,4-dimethoxyphenyl)ethylamino]-1-hydroxyethyl]phenol
Clinical data
AHFS/Drugs.com	International Drug Names
Pregnancy cat.	?
Legal status	℞ Prescription only
Routes	Oral
Identifiers
CAS number	71771-90-9
ATC code	None
PubChem	CID 71754
IUPHAR ligand	534
ChemSpider	64795
UNII	V5F60UPD8P
KEGG	D02614
Chemical data
Formula	C18H23NO4
Mol. mass	317.37 g/mol
	SMILES O(c1ccc(cc1OC)CCNC[C@@H](O)c2ccc(O)cc2)C;

　　[★]

英: denopamine
商: カルグート、デノパミール、ヘルパミン

[1] Ishide T. Denopamine, a selective beta1-receptor agonist and a new coronary vasodilator. Current Medical Research and Opinion. 2002;18(7):407-13. PMID 12487507

[2] Nakajima D, Negoro N, Nakaboh A, Nakakoji T, Hoshiga M, Nariyama J, Ishihara T, Hanafusa T. Effectiveness of low dose denopamine, a beta1-adrenoceptor agonist, in a patient with vasospastic angina refractory to intensive medical treatment. International Journal of Cardiology. 2006 Apr 4;108(2):281-3. PMID 15913812

[3] Nishio R, Matsumori A, Shioi T, Wang W, Yamada T, Ono K, Sasayama S. Denopamine, a beta1-adrenergic agonist, prolongs survival in a murine model of congestive heart failure induced by viral myocarditis: suppression of tumor necrosis factor-alpha production in the heart. Journal of the American College of Cardiology. 1998 Sep;32(3):808-15. doi:10.1016/S0735-1097(98)00314-3 PMID 9741531

[4] Sakuma T, Hida M, Nambu Y, Osanai K, Toga H, Takahashi K, Ohya N, Inoue M, Watanabe Y. Beta1-adrenergic agonist is a potent stimulator of alveolar fluid clearance in hyperoxic rat lungs. Japanese Journal of Pharmacology. 2001 Feb;85(2):161-6. doi:10.1254/jjp.85.161 PMID 11286398

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denopamine