WordNet

the 2nd letter of the Roman alphabet (同)b
the blood group whose red cells carry the B antigen (同)type_B, group B

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2012/10/16 18:55:44」(JST)

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Cytochalasin B is a cell-permeable mycotoxin. It inhibits cytoplasmic division by blocking the formation of contractile microfilaments. It inhibits cell movement and induces nuclear extrusion. Cytochalasin B shortens actin filaments by blocking monomer addition at the fast-growing end of polymers.^[1] Cytochalasin B inhibits glucose transport^[2] and platelet aggregation. It blocks adenosine-induced apoptotic body formation without affecting activation of endogenous ADP-ribosylation in leukemia HL-60 cells.^[3] It is also used in cloning through nuclear transfer. Here enucleated recipient cells are treated with Hoechst stain containing cytochalasin B. Cytochalasin B makes the walls of the oocytes smoother and makes it easy for micro-manipulation so that the zona pellucida is not so rigid and can be easily pierced by the micro-needles.

This alkaloid is isolated from a fungus, Helminthosporium dematioideum.

References

^ Theodoropoulos, PA; Gravanis, A; Tsapara, A; Margioris, AN; Papadogiorgaki, E; Galanopoulos, V; Stournaras, C (1994). "Cytochalasin B may shorten actin filaments by a mechanism independent of barbed end capping". Biochemical pharmacology 47 (10): 1875–81. doi:10.1016/0006-2952(94)90318-2. PMID 8204105. edit
^ Jung, C. Y.; Rampal, A. L. (1977). "Cytochalasin B binding sites and glucose transport carrier in human erythrocyte ghosts". The Journal of Biological Chemistry 252 (15): 5456–5463. PMID 885863. edit
^ Tanaka, Y.; Yoshihara, K.; Tsuyuki, M.; Kamiya, T. (1994). "Apoptosis Induced by Adenosine in Human Leukemia HL-60 Cells". Experimental Cell Research 213 (1): 242–559. doi:10.1006/excr.1994.1196. PMID 8020596. edit

Merck Index 13, 2819.
Benya, P.; Padilla, S. (1993). "Dihydrocytochalasin B Enhances Transforming Growth Factor-β-Induced Reexpression of the Differentiated Chondrocyte Phenotype without Stimulation of Collagen Synthesis". Experimental Cell Research 204 (2): 268–277. doi:10.1006/excr.1993.1033. PMID 8440324. edit

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English Journal

Development of a novel liquid crystal based cell traction force transducer system.

Soon CF, Youseffi M, Berends RF, Blagden N, Denyer MC.SourceFaculty of Electrical and Electronic Engineering, Universiti Tun Hussein Onn Malaysia, 83000 Batu Pahat, Johor, Malaysia. fionasoon@gmail.com
Biosensors & bioelectronics.Biosens Bioelectron.2013 Jan 15;39(1):14-20. doi: 10.1016/j.bios.2012.06.032. Epub 2012 Jun 28.
Keratinocyte traction forces play a crucial role in wound healing. The aim of this study was to develop a novel cell traction force (CTF) transducer system based on cholesteryl ester liquid crystals (LC). Keratinocytes cultured on LC induced linear and isolated deformation lines in the LC surface. A
PMID 22809522

An in vitro whole blood model to test the effects of different stimuli conditions on the release of myeloperoxidase and elastase by equine neutrophils.

Ceusters JD, Serteyn DA, Minguet G, de la Rebière de Pouyade G, Romainville J, Deby-Dupont GP, Mouithys-Mickalad AA, Franck TJ.SourceCenter for Oxygen Research and Development, Institute of Chemistry B6a, University of Liège, Sart Tilman, 4000 Liège, Belgium. Electronic address: J.ceusters@ulg.ac.be.
Veterinary immunology and immunopathology.Vet Immunol Immunopathol.2012 Dec 15;150(3-4):221-7. doi: 10.1016/j.vetimm.2012.09.008. Epub 2012 Sep 23.
Horses are particularly sensitive and exposed to excessive inflammatory responses evolving toward an important stimulation of polymorphonuclear neutrophils (PMNs). The aim of this work was to stimulate equine neutrophils in whole blood and to evaluate their response by measuring the release of total
PMID 23068273

Japanese Journal

Actin Stress Fiber Retraction and Aggresome Formation Is a Common Cellular Response to Actin Toxins

KAZAMI Sayaka,USUI Takeo,OSADA Hiroyuki
Bioscience, biotechnology, and biochemistry 75(9), 1853-1855, 2011-09-23
… Because cytochalasin D and mycalolide also induced aggresome formation, these results suggest that actin aggresome formation is a common cellular response to actin toxins. …
NAID 10029757824

Ploidy Assessment of Porcine Haploid and Diploid Parthenogenetic Embryos by Fluorescent In Situ Hybridization Detecting a Chromosome 1-Specific Sequence, Sus scrofa Mc1 Satellite DNA

SEMBON Shoichiro,FUCHIMOTO Dai-ichiro,IWAMOTO Masaki,SUZUKI Shun-ichi,ONISHI Akira
The Journal of reproduction and development 57(2), 307-311, 2011-04-01
… some were treated with cytochalasin B to prevent second PB extrusion (1PB embryos), and the others extruded the second PB (2PB embryos). …
NAID 10028275717

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★リンクテーブル★

リンク元	「サイトカラシンB」
関連記事	「B」

「サイトカラシンB」

Cytochalasin B
	Other names Phomin
Identifiers
CAS number	14930-96-2
Properties
Molecular formula	C29H37NO5
Molar mass	479.6 g/mol
Solubility in water	1.280 mg/L
Hazards
MSDS	Cytochalasin B MSDS from Fermentek
	(verify) (what is: /?); Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
	Infobox references

　　[★]

英: cytochalasin B
関: サイトカラシン

アクチン重合阻害剤

「B」

　　[★]

気管分岐部下緑
補体のalternative pathwayに関わる蛋白質

Mg2+存在下でC3, B, Dが反応してC3bBbとなり、これがC3転換酵素(C3bBb)あるいはC5転換酵素(C3bBb3b)を形成する。これらはP(properdin)と結合して活性化し、それぞれC3、C5を活性化する

[0] Theodoropoulos, PA; Gravanis, A; Tsapara, A; Margioris, AN; Papadogiorgaki, E; Galanopoulos, V; Stournaras, C (1994). "Cytochalasin B may shorten actin filaments by a mechanism independent of barbed end capping". Biochemical pharmacology 47 (10): 1875–81. doi:10.1016/0006-2952(94)90318-2. PMID 8204105. edit

[1] Jung, C. Y.; Rampal, A. L. (1977). "Cytochalasin B binding sites and glucose transport carrier in human erythrocyte ghosts". The Journal of Biological Chemistry 252 (15): 5456–5463. PMID 885863. edit

[2] Tanaka, Y.; Yoshihara, K.; Tsuyuki, M.; Kamiya, T. (1994). "Apoptosis Induced by Adenosine in Human Leukemia HL-60 Cells". Experimental Cell Research 213 (1): 242–559. doi:10.1006/excr.1994.1196. PMID 8020596. edit

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案内

案内

cytochalasin B