- 同
- CMP
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2012/11/16 11:42:45」(JST)
[Wiki en表示]
| Cytidine monophosphate |
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| Identifiers |
| CAS number |
63-37-6 Y |
| PubChem |
6131 |
| ChemSpider |
5901 Y |
| ChEBI |
CHEBI:17361 Y |
| ChEMBL |
CHEMBL307679 Y |
| Jmol-3D images |
Image 1 |
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c1cn(c(=O)nc1N)[C@H]2[C@@H]([C@@H]([C@H](O2)COP(=O)(O)O)O)O
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InChI=1S/C9H14N3O8P/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H2,10,11,15)(H2,16,17,18)/t4-,6-,7-,8-/m1/s1 Y
Key: IERHLVCPSMICTF-XVFCMESISA-N Y
InChI=1/C9H14N3O8P/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H2,10,11,15)(H2,16,17,18)/t4-,6-,7-,8-/m1/s1
Key: IERHLVCPSMICTF-XVFCMESIBY
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| Properties |
| Molecular formula |
C9H14N3O8P |
| Molar mass |
323.20 g/mol |
| Acidity (pKa) |
0.8, 4.5, 6.3 |
Y (verify) (what is: Y/N?)
Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa) |
| Infobox references |
Cytidine monophosphate, also known as 5'-cytidylic acid or simply cytidylate, and abbreviated CMP, is a nucleotide that is used as a monomer in RNA.[1] It is an ester of phosphoric acid with the nucleoside cytidine. CMP consists of the phosphate group, the pentose sugar ribose, and the nucleobase cytosine; hence, a ribonucleoside monophosphate. As a substituent it takes the form of the prefix cytidylyl-.
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Contents
- 1 Metabolism
- 2 Biochemistry
- 3 See also
- 4 References
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Metabolism
CMP can be phosphorylated to Cytidine diphosphate by the enzyme CMP kinase, with Adenosine triphosphate or guanine triphosphate donating the phosphate group. Since Cytidine triphosphate is generated by amination of uridine triphosphate, the main source of CMP is from RNA being decomposed, e.g. by RNAse.
Biochemistry
CMP is used to activate mannose in metabolism.
See also
- Nucleoside
- Nucleotide
- DNA
- RNA
- Oligonucleotide
- Ribonucleoside monophosphate
References
- ^ Pascal JM (February 2008). "DNA and RNA ligases: structural variations and shared mechanisms". Curr. Opin. Struct. Biol. 18 (1): 96–105. doi:10.1016/j.sbi.2007.12.008. PMID 18262407. http://linkinghub.elsevier.com/retrieve/pii/S0959-440X(07)00208-4.
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Nucleic acid constituents
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| Nucleobase |
Purine (Adenine, Guanine, Purine analogue) · Pyrimidine (Uracil, Thymine, Cytosine, Pyrimidine analogue)
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| Nucleoside |
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Ribonucleoside
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Adenosine · Guanosine · 5-Methyluridine · Uridine · Cytidine
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Deoxyribonucleoside
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Deoxyadenosine · Deoxyguanosine · Thymidine · Deoxyuridine · Deoxycytidine
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Nucleotide
(Nucleoside monophosphate) |
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Ribonucleotide
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AMP, GMP, m5UMP, UMP, CMP
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Deoxyribonucleotide
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dAMP, dGMP, dTMP, dUMP, dCMP
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Cyclic nucleotide
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cAMP, cGMP, c-di-GMP, cADPR
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| Nucleoside diphosphate |
ADP, GDP, m5UDP, UDP, CDP · dADP, dGDP, dTDP, dUDP, dCDP
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| Nucleoside triphosphate |
ATP, GTP, m5UTP, UTP, CTP · dATP, dGTP, dTTP, dUTP, dCTP
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- biochemical families: proteins (amino acids/intermediates)
- nucleic acids (constituents/intermediates)
- carbohydrates (glycoproteins, alcohols, glycosides)
- lipids (fatty acids/intermediates, phospholipids, steroids, sphingolipids, eicosanoids)
- tetrapyrroles/intermediates
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UpToDate Contents
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English Journal
- Water-extracted plum (Prunus salicina L. cv. Soldam) attenuates adipogenesis in murine 3T3-L1 adipocyte cells through the PI3K/Akt signaling pathway.
- Choe WK1, Kang BT1, Kim SO2.
- Experimental and therapeutic medicine.Exp Ther Med.2018 Feb;15(2):1608-1615. doi: 10.3892/etm.2017.5569. Epub 2017 Nov 27.
- PMID 29399132
- Crystal structure of IspF from Bacillus subtilis and absence of protein complex assembly among IspD/IspE/IspF enzymes in the MEP pathway.
- Liu Z1, Jin Y1, Liu W2, Tao Y2, Wang G3.
- Bioscience reports.Biosci Rep.2018 Jan 15. pii: BSR20171370. doi: 10.1042/BSR20171370. [Epub ahead of print]
- PMID 29335298
- Metabolomic effects of CeO2, SiO2 and CuO metal oxide nanomaterials on HepG2 cells.
- Kitchin KT1, Stirdivant S2, Robinette BL3, Castellon BT3, Liang X4.
- Particle and fibre toxicology.Part Fibre Toxicol.2017 Nov 29;14(1):50. doi: 10.1186/s12989-017-0230-4.
- PMID 29187207
Japanese Journal
- Production and Purification of Secretory Simian Cytidine Monophosphate-N-acetylneuraminic Acid Hydroxylase Using Baculovirus-Protein Expression System
- Structural Transitions and Enzymatic Function of Ribonuclease A Encapsulated in Transparent Porous Silica Gel
- Bulletin of the Chemical Society of Japan 83(8), 935-941, 2010-08-15
- NAID 10026510560
- Cloning and characterization of cytidine monophosphate-3-deoxy-D-manno-octulosonate synthetase from Arabidopsis thaliana(PLANT BIOTECHNOLOGY)
Related Links
- Favorite Button CITE Translate Facebook Share Twitter Tweet Google+ Share cytidine monophosphate noun, Biochemistry 1. a nucleotide constituent of ribonucleic acids; a phosphoric acid ester of ...
- cytidylic acid /cy·ti·dyl·ic ac·id/ (si″tĭ-dil´ik) phosphorylated cytidine, usually cytidine monophosphate. cy·ti·dyl·ic acid (s t-d l k, s t-) n. A component of RNA that hydrolyzes to yield cytosine, d-ribose, and phosphoric acid. Also called cytidine monophosphate
★リンクテーブル★
[★]
- 英
- cytidine monophosphate, CMP
- 関
- シチジル酸、シチジン
[★]
- 関
- cytidine monophosphate、cytidylic acid
[★]
- 関
- CMP、cytidine monophosphate
[★]
シチジン一リン酸N-アセチルノイラミン酸
- 関
- CMP-NANA
[★]
デオキシシチジン一リン酸
- 関
- dCMP
[★]