cutaneous cryptococcosis

皮膚クリプトコッカス症

WordNet

1. relating to or existing on or affecting the skin; "cutaneous nerves"; "a cutaneous infection" (同)cutaneal, dermal
2. a fungal infection characterized by nodular lesions--first in the lungs and spreading to the nervous system

PrepTutorEJDIC

1. 皮膚の,皮膚を冒す

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/07/02 13:45:24」(JST)

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Not to be confused with Cryptosporidiosis.

Cryptococcosis
Micrograph of cryptococcosis showing the characteristically thick capsule of cryptococcus. Field stain.
Classification and external resources
Specialty	Infectious disease, Pulmonology
ICD-10	B45
ICD-9	117.5
DiseasesDB	3213
MedlinePlus	001328
eMedicine	med/482
Patient UK	Cryptococcosis
MeSH	D003453

Cryptococcosis, or cryptococcal disease, is a potentially fatal fungal disease. It is caused by one of two species; Cryptococcus neoformans and Cryptococcus gattii. These were all previously thought to be subspecies of C. neoformans but have now been identified as distinct species.

Cryptococcosis is believed to be acquired by inhalation of the infectious propagule from the environment. Although the exact nature of the infectious propagule is unknown, the leading hypothesis is the basidiospore created through sexual or asexual reproduction.

Cause

Cryptococcosis is a defining opportunistic infection for AIDS, and is the second-most-common AIDS-defining illness in Africa. Other conditions that pose an increased risk include certain lymphomas (e.g., Hodgkin's lymphoma), sarcoidosis, liver cirrhosis, and patients on long-term corticosteroid therapy.

Distribution is worldwide in soil. The prevalence of cryptococcosis has been increasing over the past 20 years for many reasons, including the increase in incidence of AIDS and the expanded use of immunosuppressive drugs.

In humans, C. neoformans causes three types of infections:

• Wound or cutaneous cryptococcosis
• Pulmonary cryptococcosis
• Cryptococcal meningitis.

Cryptococcal meningitis (infection of the meninges, the tissue covering the brain) is believed to result from dissemination of the fungus from either an observed or unappreciated pulmonary infection. Often there is also silent dissemination throughout the brain when meningitis is present. Cryptococcus gattii causes infections in immunocompetent people (fully functioning immune system), but C. neoformans v. grubii, and v. neoformans usually only cause clinically evident infections in persons with some form of defect in their immune systems (immunocompromised persons). People with defects in their cell-mediated immunity, for example, people with AIDS, are especially susceptible to disseminated cryptococcosis. Cryptococcosis is often fatal, even if treated. It is estimated that the three-month case-fatality rate is 9% in high-income regions, 55% in low/middle-income regions, and 70% in sub-Saharan Africa. As of 2009 there were globally approximately 958,000 annual cases and 625,000 deaths within three months after infection.

Although the most common presentation of cryptococcosis is of C. neoformans infection in an immunocompromised person (such as persons living with AIDS), the C. gattii is being increasingly recognised as a pathogen in what is presumed to be immunocompetent hosts, especially in Canada and Australia. This may be due to rare exposure and high pathogenicity, or to unrecognised isolated defects in immunity, specific for this organism.

Diagnosis

Dependent on the infectious syndrome, symptoms include fever, fatigue, dry cough, headache, blurred vision, and confusion. Symptom onset is often subacute, progressively worsened over several weeks. The two most common presentations are meningitis (an infection in and around the brain) and pulmonary (lung) infection.

Detection of cryptococcal antigen (capsular material) by culture of CSF, sputum and urine provides definitive diagnosis. Blood cultures may be positive in heavy infections. India ink of the CSF is a traditional microscopic method of diagnosis, although the sensitivity is poor in early infection, and may miss 15-20% of patients with culture-positive cryptococcal meningitis. Unusual morphological forms are rarely seen. Cryptococcal antigen from cerebrospinal fluid is the best test for diagnosis of cryptococcal meningitis in terms of sensitivity. Apart from conventional methods of detection like direct microscopy and culture, rapid diagnostic methods to detect cryptococcal antigen by latex agglutination test, lateral flow immunochromatographic assay (LFA), or enzyme immunoassay (EIA). A new cryptococcal antigen LFA was FDA approved in July 2011. Polymerase chain reaction (PCR) has been used on tissue specimens.

Cryptococcosis can rarely occur in the non-immunosuppressed people, particularly with Cryptococcus gattii.

Prevention

Cryptococcosis is a very subacute infection with a prolonged subclinical phase lasting weeks to months in persons with HIV/AIDS before the onset of symptomatic meningitis. In Sub-Saharan Africa, the prevalence rates of detectable cryptococcal antigen in perpheral blood is often 4-12% in persons with CD4 counts lower than 100 cells/mcL. Cryptococcal antigen screen and preemptive treatment with fluconazole is cost saving to the healthcare system by avoiding cryptococcal meningitis. The World Health Organization recommends cryptococcal antigen screening in HIV-infected persons entering care with CD4<100 cells/μL. This undetected subclinical cryptococcal (if not preemptively treated with anti-fungal therapy) will often go on to develop cryptococcal meningitis, despite receiving HIV therapy. Cryptococcosis accounts for 20-25% of the mortality after initiating HIV therapy in Africa. What is effective preemptive treatment is unknown, with the current recommendations on dose and duration based on expert opinion. Screening in the United States is controversial, with official guidelines not recommending screening, despite cost-effectiveness and a 3% U.S. cryptococcal antigen prevalence in CD4<100 cells/μL.

Treatment

Treatment options in persons without HIV-infection have not been well studied. Intravenous Amphotericin B combined with flucytosine by mouth is recommended.

Persons living with AIDS often have a greater burden of disease and higher mortality (30-70% at 10-weeks), but recommended therapy is with amphotericin B and flucytosine. Where flucytosine is not available (i.e. all low and middle income countries), fluconazole should be used adjunctively with amphotericin. Amphotericin-based induction therapy has much greater microbiologic activity than fluconazole monotherapy with 30% better survival at 10-weeks. Based on a systematic review of existing data, the most cost-effective induction treatment in resource-limited settings appears to be one week of amphotericin B coupled with high-dose fluconazole. After initial induction treatment as above, typical consolidation therapy is with oral fluconazole for at least 8 weeks used with secondary prophylaxis with fluconazole thereafter.

The decision on when to start treatment for HIV appears to be very different than other opportunistic infections. A large multi-site trial supports deferring ART for 4–6 weeks was overall preferable with 15% better 1-year survival than earlier ART initiation at 1–2 weeks after diagnosis. A Cochrane review also supports the delayed starting of treatment until crytococcosis starts improving with antifungal treatment.

IRIS in those with normal immune function

The immune reconstitution inflammatory syndrome (IRIS) has been described in those with normal immune function with meningitis caused by C. gattii and C. grubii. Several weeks or even months into appropriate treatment, there can be deterioration with worsening meningitis symptoms and progression or development of new neurological symptoms. IRIS is however much more common in those with poor immune function (~25% vs. ~8%).

Magnetic resonance imaging shows increase in the size of brain lesions, and CSF abnormalities (white cell count, protein, glucose) increase. Radiographic appearance of cryptococcal IRIS brain lesions can mimic that of toxoplasmosis with ring enhancing lesions on head computed tomography (CT). CSF culture is sterile, and there is no increase in CSF cryptococcal antigen titre.

The increasing inflammation can cause brain injury or be fatal.

The mechanism behind IRIS in cryptococcal meningitis is primarily immunologic. With reversal of immunosuppression, there is paradoxical increased inflammation as the recovering immune system recognises the fungus. In severe IRIS cases, treatment with systemic corticosteroids has been utilized - although evidence-based data are lacking.

Other animals

Cryptococcosis is also seen in cats and occasionally dogs. It is the most common deep fungal disease in cats, usually leading to chronic infection of the nose and sinuses, and skin ulcers. Cats may develop a bump over the bridge of the nose from local tissue inflammation. It can be associated with FeLV infection in cats. Cryptococcosis is most common in dogs and cats but cattle, sheep, goats, horses, wild animals, and birds can also be infected. Soil, fowl manure, and pigeon droppings are among the sources of infection.

References

External links

• "Cryptococcosis (European Blastomycosis; Torulosis)". Merck Manual: Health Care Professionals: Infectious Diseases: Fungi. April 2009. 
• PreventCrypto.org is a clearinghouse for information as an international collaboration between government and non-governmental organizations, academic institutions, and private industry partners—who are dedicated to reducing the global burden of cryptococcal disease.
• Health AtoZ
• Busse-Buschke disease at Who Named It?
• See pathology video with commentary of brain tissue infested by Cryptoccocus neoformans
• Medscape entry on cryptococcosis

UpToDate Contents

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

• 1. 中枢神経系以外のクリプトコッカス感染症 cryptococcal infection outside the central nervous system
• 2. HIV感染患者における発熱および発疹 fever and rash in hiv infected patients
• 3. 新生児における特殊な真菌感染症 unusual fungal infections in the neonate
• 4. クリプトコッカス感染症の微生物学および疫学 microbiology and epidemiology of cryptococcal infection
• 5. 非HIV免疫不全ホストにおける高熱および発疹の感染性原因 infectious causes of fever and rash in non hiv immunocompromised hosts

English Journal

• Fatal primary cutaneous cryptococcosis: case report and review of published literature.

• Liu Y1, Qunpeng H, Shutian X, Honglang X.
• Irish journal of medical science.Ir J Med Sci.2015 Aug 6. [Epub ahead of print]
• OBJECTIVE: Cryptococcus is an opportunistic yeast with a worldwide distribution that primarily causes significant infections in immunocompromised individuals, generally by affecting the respiratory tract. But primary cutaneous cryptococcosis (PCC) without systemic infection is rare. We report a case
• PMID 26246081

• Systemic Review of Published Reports on Primary Cutaneous Cryptococcosis in Immunocompetent Patients.

• Du L1, Yang Y, Gu J, Chen J, Liao W, Zhu Y.
• Mycopathologia.Mycopathologia.2015 Aug;180(1-2):19-25. doi: 10.1007/s11046-015-9880-7. Epub 2015 Mar 4.
• Primary cutaneous cryptococcosis (PCC) has been confirmed as a distinct clinical entity with secondary cutaneous cryptococcosis from systematic infection since 2003. Although it has been confirmed as a distinct clinical entity, little has progressed on PCC in immunocompetent hosts compared to their
• PMID 25736173

• Cutaneous Cryptococcus: marker for disseminated infection.

• Srivastava GN1, Tilak R2, Yadav J3, Bansal M3.
• BMJ case reports.BMJ Case Rep.2015 Jul 21;2015. pii: bcr2015210898. doi: 10.1136/bcr-2015-210898.
• Cryptococcosis is an infection caused by the encapsulated yeast, Cryptococcus neoformans, a dimorphic fungus recovered from pigeon excreta, soil, dust and human skin. After a primary infection in the lungs, the disease can disseminate via a haematogenous route to various organs, including the centra
• PMID 26199299

Japanese Journal

• 類天疱瘡治療中の患者に生じた原発性皮膚クリプトコッカス症の1例 (特集 真菌症)

• 松尾 梨沙,林 圭,辻 ひとみ [他]
• 皮膚科の臨床 55(8), 977-981, 2013-08
• NAID 40019785975

• 関節リウマチに合併した続発性皮膚クリプトコッカス症の1例 (特集 真菌症)

• 磯田 祐士,大野 真梨恵,久田 恭子 [他]
• 皮膚科の臨床 55(8), 971-976, 2013-08
• NAID 40019785936

• 原発性皮膚クリプトコッカス症の1例 (特集 真菌症)

• 三枝 良輔,山田 大資,浅野 善英 [他]
• 皮膚科の臨床 55(8), 966-969, 2013-08
• NAID 40019785908

Related Links

• Cutaneous Cryptococcosis: a marker of life threatening ...

Original Articles / Prace Oryginalne CUTANEOUS CRYPTOCOCCOSIS: A MARKER OF LIFE THREATENING DISSEMINATED CRYPTOCOCCOSIS IN HIV AIDS SKÓRNA KRYPTOKOKOZA: MARKER ZAGRAśAJĄCY śYCIU ...

• Cryptococcosis - ScienceDirect.com | Science, health and ...

Clinical manifestations Cryptococcosis may present as chronic lung disease, a unifocal extrapulmonary condition with cutaneous or neurologic manifestations, or a disseminated process. 1 Pulmonary cryptococcosis This involvement ...

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★リンクテーブル★

リンク元	「皮膚クリプトコッカス症」
関連記事	「cutaneous」「cryptococcosis」

「皮膚クリプトコッカス症」

　　[★]

英

cutaneous cryptococcosis

「cutaneous」

　　[★]

• adj.

• 皮膚の、皮膚性の

関

cutaneously、cutis、dermal、skin

　 　

「cryptococcosis」

　　[★] クリプトコッカス症