関: chondroitinase ABC

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the 1st letter of the Roman alphabet (同)a
the blood group whose red cells carry the A antigen (同)type_A, group A
the blood group whose red cells carry both the A and B antigens (同)type_AB, group AB

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2017/08/06 05:06:36」(JST)

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Chondroitin ABC lyase (EC 4.2.2.4, chondroitinase, chondroitin ABC eliminase, chondroitinase ABC) is an enzyme with systematic name chondroitin ABC lyase.^[1]^[2] This enzyme catalyses the following chemical reaction

Eliminative degradation of polysaccharides containing 1,4-beta-D-hexosaminyl and 1,3-beta-D-glucuronosyl or 1,3-alpha-L-iduronosyl linkages to disaccharides containing 4-deoxy-beta-D-gluc-4-enuronosyl groups

This enzyme acts on chondroitin 4-sulfate, chondroitin 6-sulfate and dermatan sulfate.

Uses

Following a spinal cord injury, this enzyme can be used to erode scar tissue that can interfere with regeneration.^[3]

References

^ Yamagata, T.; Saito, H.; Habuchi, O.; Suzuki, S. (1968). "Purification and properties of bacterial chondroitinases and chondrosulfatases". J. Biol. Chem. 243: 1523–1535. PMID 5647268.
^ Saito, H.; Yamagata, T.; Suzuki, S. (1968). "Enzymatic methods for the determination of small quantities of isomeric chondroitin sulfates". J. Biol. Chem. 243: 1536–1542. PMID 4231029.
^ https://www.eurekalert.org/pub_releases/2014-04/sfn-gti033114.php

External links

Chondroitin ABC lyase at the US National Library of Medicine Medical Subject Headings (MeSH)

UpToDate Contents

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English Journal

Monocyte-to-macrophage differentiation: synthesis and secretion of a complex extracellular matrix.

Chang MY, Chan CK, Braun KR, Green PS, O'Brien KD, Chait A, Day AJ, Wight TN.SourceMetabolism, Endocrinology and Nutrition, Department of Medicine, University of Washington, Seattle, Washington 98195, USA.
The Journal of biological chemistry.J Biol Chem.2012 Apr 20;287(17):14122-35. Epub 2012 Feb 20.
Although monocyte- and macrophage-derived molecules are known to promote extracellular matrix (ECM) disruption and destabilization, it is less appreciated that they also synthesize molecules contributing to ECM formation, stabilization, and function. We have identified and characterized the synthesi
PMID 22351750

Neuronal glycosylation differentials in normal, injured and chondroitinase-treated environments.

Kilcoyne M, Sharma S, McDevitt N, O'Leary C, Joshi L, McMahon SS.SourceGlycoscience Group, National Centre for Biomedical Engineering Science, National University of Ireland, Galway, Ireland.
Biochemical and biophysical research communications.Biochem Biophys Res Commun.2012 Apr 13;420(3):616-22. Epub 2012 Mar 20.
Glycosylation is found ubiquitously throughout the central nervous system (CNS). Chondroitin sulphate proteoglycans (CSPGs) are a group of molecules heavily substituted with glycosaminoglycans (GAGs) and are found in the extracellular matrix (ECM) and cell surfaces. Upon CNS injury, a glial scar is
PMID 22465128

Japanese Journal

Characterization of Chondroitin/Dermatan Sulfate Proteoglycans Synthesized by Bovine Retinal Pericytes in Culture(Highlighted paper selected by Editor-in-chief)(Biochemistry/Molecular Biology)

KAJI Toshiyuki,SAKURAI Shigeru,YAMAMOTO Chika,FUJIWARA Yasuyuki,YAMAGISHI Sho-ichi,YAMAMOTO Hiroshi,KINSELLA Michael G.,WIGHT Thomas N.
Biological & pharmaceutical bulletin 27(11), 1763-1768, 2004-11-01
… Separated proteoglycans were digested with papain, heparitinase or chondroitin ABC lyase and the GAGs characterized by Sepharose CL-6B chromatography. … Proteoglycans were also assessed by sodium dodecyl sulfate polyacrylamide gel electrophoresis before and after digestion with chondroitin ABC lyase. …
NAID 110003608693

REGULATION OF BIGLYCAN AND DECORIN SYNTHESIS BY CONNECTIVE TISSUE GROWTH FACTOR IN CULTURED BOVINE AORTIC ENDOTHELIAL CELLS

Yamamoto Chika,Oh-i Mami,Fujiwara Yasuyuki,Kaji Toshiyuki,Nishida Takashi,Nakanishi Tohru,Takigawa Masaharu,Kinsella Michael G.,Wight Thomas N.
Connective tissue 34(1), 50, 2002-04
… The glycosaminoglycan (GAGs) M_r and composition were analyzed by Sepharose CL-6B chromatography, and the core protein M_r was analyzed by SDS-polyacrylamide gel electrophoresis, before and after digestion with papain, heparitinase or chondroitin ABC lyase. … However, neither the hydrodynamic size nor the GAG chain length of these two small chondroitin/dermatan sulfate proteoglycans was changed by the growth factor. …
NAID 110004002464

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リンク元	「コンドロイチンABCリアーゼ」「chondroitinase ABC」
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Chondroitin ABC lyase
Identifiers
EC number	4.2.2.4
CAS number	9024-13-9
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
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　　[★]

英: chondroitin ABC lyase
関: コンドロイチナーゼABC

「chondroitinase ABC」

　　[★]

コンドロイチナーゼABC

関: chondroitin ABC lyase

「A」

　　[★]

「ABC」

　　[★]

「AB」

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同: asthmatic bronchitis, 喘息性気管支炎

[1] Yamagata, T.; Saito, H.; Habuchi, O.; Suzuki, S. (1968). "Purification and properties of bacterial chondroitinases and chondrosulfatases". J. Biol. Chem. 243: 1523–1535. PMID 5647268.

[2] Saito, H.; Yamagata, T.; Suzuki, S. (1968). "Enzymatic methods for the determination of small quantities of isomeric chondroitin sulfates". J. Biol. Chem. 243: 1536–1542. PMID 4231029.

[3] ttps://www.eurekalert.org/pub_releases/2014-04/sfn-gti033114.php

v t e Carbon-oxygen lyases (EC 4.2) (primarily dehydratases)
4.2.1: Hydro-Lyases	Carbonic anhydrase Fumarase Aconitase Enolase Alpha Enolase 2 Enoyl-CoA hydratase/3-Hydroxyacyl ACP dehydrase Methylglutaconyl-CoA hydratase Tryptophan synthase Cystathionine beta synthase Porphobilinogen synthase 3-Isopropylmalate dehydratase Urocanase Uroporphyrinogen III synthase Nitrile hydratase
4.2.2: Acting on polysaccharides	Hyaluronate lyase
4.2.3: Acting on phosphates	Threonine synthase
4.2.99: Other	Carboxymethyloxysuccinate lyase

v t e Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Catalytically perfect enzyme Coenzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list)

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chondroitin ABC lyase