同: CAIV

WordNet

an abundant nonmetallic tetravalent element occurring in three allotropic forms: amorphous carbon and graphite and diamond; occurs in all organic compounds (同)C, atomic number 6
a copy made with carbon paper (同)carbon_copy
the 9th letter of the Roman alphabet (同)i

PrepTutorEJDIC

『炭素』(化学記号は『C』) / 〈C〉炭素棒 / 〈C〉《時に〈U〉》=carbon paper
『私は』私が
iodineの化学記号

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2013/02/08 20:01:24」(JST)

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Carbonic anhydrase 4 is an enzyme that in humans is encoded by the CA4 gene.^[1]^[2]

Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. CA IV is a glycosylphosphatidyl-inositol-anchored membrane isozyme expressed on the luminal surfaces of pulmonary (and certain other) capillaries and of proximal renal tubules. Its exact function is not known, however, it may have a role in inherited renal abnormalities of bicarbonate transport.^[2]

Interactions

CA4 has been shown to interact with Band 3.^[3]

References

^ Okuyama T, Batanian JR, Sly WS (Aug 1993). "Genomic organization and localization of gene for human carbonic anhydrase IV to chromosome 17q". Genomics 16 (3): 678–84. doi:10.1006/geno.1993.1247. PMID 8325641.
^ ^a ^b "Entrez Gene: CA4 carbonic anhydrase IV". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=762.
^ Sterling, Deborah; Alvarez Bernardo V, Casey Joseph R (Jul. 2002). "The extracellular component of a transport metabolon. Extracellular loop 4 of the human AE1 Cl-/HCO3- exchanger binds carbonic anhydrase IV". J. Biol. Chem. (United States) 277 (28): 25239–46. doi:10.1074/jbc.M202562200. ISSN 0021-9258. PMID 11994299.

External links

GeneReviews/NCBI/NIH/UW entry on Retinitis Pigmentosa Overview

This article on a gene on chromosome 17 is a stub. You can help Wikipedia by expanding it.

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1. 利尿剤の作用機序 mechanism of action of diuretics
2. 尿細管性アシドーシスにおける腎結石症 nephrolithiasis in renal tubular acidosis
3. 代謝性アルカローシスの治療 treatment of metabolic alkalosis
4. 小児における痙攣およびてんかん：初期治療およびモニタリング seizures and epilepsy in children initial treatment and monitoring
5. 幼児および小児における尿細管性アシドーシスの病因および臨床症状 etiology and clinical manifestations of renal tubular acidosis in infants and children

English Journal

Intraocular pressure efficacy of glaucoma medications versus placebo in phase II compared to later phase trials.

Sharpe RA, Nelson LA, Stewart JA, Stewart WC.SourcePRN Pharmaceutical Research Network, LLC, 109 East 17th Street, Suite 3407, Cheyenne, Wyoming 82001, USA; info@prnorb.com.
The British journal of ophthalmology.Br J Ophthalmol.2013 Feb;97(2):121-5. doi: 10.1136/bjophthalmol-2012-302046. Epub 2012 Oct 11.
This review aimed to compare the predictive value between the untreated reduction in intraocular pressure (IOP) from baseline or placebo measured in early phase clinical trials to phase III and IV results for glaucoma medicines. Published, placebo-controlled, randomised, parallel, single-masked or d
PMID 23060621

GPI-anchored carbonic anhydrase IV displays both intra- and extracellular activity in cRNA-injected oocytes and in mouse neurons.

Schneider HP, Alt MD, Klier M, Spiess A, Andes FT, Waheed A, Sly WS, Becker HM, Deitmer JW.SourceAbteilung für Allgemeine Zoologie, and Arbeitsgruppe Zoologie/Membrantransport, Fachbereich Biologie, University of Kaiserslautern, D-67653 Kaiserslautern, Germany.
Proceedings of the National Academy of Sciences of the United States of America.Proc Natl Acad Sci U S A.2013 Jan 22;110(4):1494-9. doi: 10.1073/pnas.1221213110. Epub 2013 Jan 7.
Soluble cytosolic carbonic anhydrases (CAs) are well known to participate in pH regulation of the cytoplasm of mammalian cells. Membrane-bound CA isoforms-such as isoforms IV, IX, XII, XIV, and XV-also catalyze the reversible conversion of carbon dioxide to protons and bicarbonate, but at the extrac
PMID 23297198

Regression of glioma tumor growth in F98 and U87 rat glioma models by the Nitrone OKN-007.

Towner RA, Gillespie DL, Schwager A, Saunders DG, Smith N, Njoku CE, Krysiak RS 3rd, Larabee C, Iqbal H, Floyd RA, Bourne DW, Abdullah O, Hsu EW, Jensen RL.SourceAdvanced Magnetic Resonance Center (R.A.T., D.G.S., N.S., C.E.N., R.S.K., C.L., H.I.) and Experimental Therapeutics Laboratory, Oklahoma Medical Research Foundation (R.A.F.), and Department of Pharmaceutical Sciences, The University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma (D.W.A.B.); Huntsman Cancer Institute, University of Utah Health Sciences Center (D.L.G., R.L.J.), Interdepartmental Program in Neuroscience (A.S.), Department of Bioengineering (O.A., E.W.H.), and Departments of Neurosurgery, Radiation Oncology, Oncological Sciences, Clinical Neurosciences Center, University of Utah, Salt Lake City, Utah (R.L.J.).
Neuro-oncology.Neuro Oncol.2013 Jan 17. [Epub ahead of print]
BackgroundGlioblastoma multiforme, a World Health Organization grade IV glioma, has a poor prognosis in humans despite current treatment options. Here, we present magnetic resonance imaging (MRI) data regarding the regression of aggressive rat F98 gliomas and human U87 glioma xenografts after treatm
PMID 23328810

Japanese Journal

犬乳腺ならびに乳腺腫瘍における炭酸脱水酵素の発現(解剖学)

Jen Yi-Fan,Lee Wei-Ming,Lin Cheng-Chung [他],ほか4名,WANG Jiann-Hsiung,KUO Tzong-Fu,CHANG Ming-Huang
The journal of veterinary medical science 70(5), 437-441, 2008-05-25
… 炭酸脱水酵素(carbonic anhydrase, CA)は亜鉛を含む金属酵素で,哺乳類組織に広く分布し,二酸化炭素の可逆的加水分解によって呼吸,酸塩基平衡,イオン輸送,骨吸収などの生理的調節,さらには腫瘍の発達にも関与している.しかし,乳腺組織におけるCAの発現については報告がない.本研究では,正常乳腺組織ならびに乳腺腫瘍組織両者のCA発現を組織検索とRT-PCRによって検討した.犬の正常乳腺組織と乳腺腫瘍組織 …
NAID 110006688946

Serum antibodies to carbonic anhydrase IV in patients with autoimmune pancreatitis

Nishimori I.,Miyaji E.,Morimoto K.,Nagao K.,Kamada M.,Onishi S.
Gut 54, 274-281, 2005-02
NAID 120001614075

Carbonic anhydrase IV and XIV knockout mice : roles of the respective carbonic anhydrases in buffering the extracellular space in brain

SHAH GN
Proc Natl Acad Sci USA 102, 16771-16776, 2005
NAID 80017632903

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関連記事	「I」「carbonic」「IV」「anhydrase」「carbon」

「I」

Carbonic anhydrase IV
	; PDB rendering based on 1znc.
Available structures
PDB	Ortholog search: PDBe, RCSB
List of PDB id codes
	1ZNC, 3F7B, 3F7U, 3FW3
Identifiers
Symbols	CA4; CAIV; Car4; RP17
External IDs	OMIM: 114760 MGI: 1096574 HomoloGene: 20183 ChEMBL: 3729 GeneCards: CA4 Gene
EC number	4.2.1.1
Gene Ontology
Molecular function	• carbonate dehydratase activity; • protein binding; • zinc ion binding; • metal ion binding;
Cellular component	• rough endoplasmic reticulum; • endoplasmic reticulum-Golgi intermediate compartment; • Golgi apparatus; • trans-Golgi network; • plasma membrane; • cell surface; • membrane; • basolateral plasma membrane; • apical plasma membrane; • sarcoplasmic reticulum; • transport vesicle membrane; • secretory granule membrane; • anchored to external side of plasma membrane; • brush border membrane; • sarcolemma; • plasma membrane part; • perinuclear region of cytoplasm;
Biological process	• one-carbon metabolic process; • bicarbonate transport; • response to drug; • small molecule metabolic process; • organ development; • response to steroid hormone stimulus;
	Sources: Amigo / QuickGO
RNA expression pattern
	More reference expression data
Orthologs
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