骨髄腫瘍、骨髄新生物
WordNet
- remove the bones from; "bone the turkey before roasting it" (同)debone
- the porous calcified substance from which bones are made (同)osseous_tissue
- consisting of or made up of bone; "a bony substance"; "the bony framework of the body"
- a shade of white the color of bleached bones (同)ivory, pearl, off-white
- rigid connective tissue that makes up the skeleton of vertebrates (同)os
- any of various squash plants grown for their elongated fruit with smooth dark green skin and whitish flesh (同)marrow squash, vegetable_marrow
- the fatty network of connective tissue that fills the cavities of bones (同)bone_marrow
- very tender and very nutritious tissue from marrowbones (同)bone_marrow
- large elongated squash with creamy to deep green skins (同)vegetable_marrow
- having bones as specified; "his lanky long-boned body"
- having had the bones removed; "a boneless rib roast"; "a boned (or deboned) fish" (同)deboned
- a percussion instrument consisting of a pair of hollow pieces of wood or bone (usually held between the thumb and fingers) that are made to click together (as by Spanish dancers) in rhythm with the dance (同)castanets, clappers, finger cymbals
PrepTutorEJDIC
- 〈C〉骨 / 〈U〉骨を作っている物質,骨質 / 《複数形で》骨格;死骸(がい) / 〈魚など〉‘の'骨を取る
- 髄(ずい),骨髄 / 精髄,粋 / 力,活力
- (魚など)骨を取り除いた / (衣服が)(コルセットなどで)骨で張りをつけた[ような]
- (体内にできる)新生物;腫瘍(しゅよう)
UpToDate Contents
全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.
English Journal
- Cell intrinsic and extrinsic factors synergize in mice with haploinsufficiency for Tp53, and two human del(5q) genes, Egr1 and Apc.
- Stoddart A, Wang J, Fernald AA, Karrison T, Anastasi J, Le Beau MM.Author information Department of Medicine.AbstractTherapy-related myeloid neoplasms (t-MN) are a late complication of the successful use of cytotoxic therapy for patients with cancer. A heterozygous deletions of the long arm of chromosome 5 [del(5q)], observed in 40% of patients, is associated with prior exposure to alkylating agents, and a high frequency of TP53 loss or mutation. In previous studies, we demonstrated that haploinsufficiency of 2 del(5q) genes, Egr1, and Apc, individually play a role in the pathogenesis of hematologic disease in mice. We now show that loss of one copy of Egr1 or Tp53 in an Apc haploinsufficient background (Apc (del/+)) accelerated the development of a macrocytic anemia with monocytosis, early features of t-MN. The development of anemia was significantly accelerated by treatment of mice with the alkylating agent, N-ethyl-N-nitrosourea (ENU), regardless of the levels of expression of Egr1 and Tp53. Transplantation of either wild type; Egr1(+/-); Tp53(+/-); Apc(del/+); or Egr1(+/-), Apc(del/+) bone marrow cells into lethally irradiated Apc(del/+) recipients resulted in rapid development of anemia that was further accelerated by administration of ENU to recipients, demonstrating that the Apc(del/+)-induced anemia was cell extrinsic and potentiated by ENU mutagenesis. These data emphasize the synergistic role of cell intrinsic and cell extrinsic (microenvironment) factors in the pathogenesis of t-MN, and raise awareness of the deleterious effects of cytotoxic therapy on the stromal microenvironment.
- Blood.Blood.2014 Jan 9;123(2):228-38. doi: 10.1182/blood-2013-05-506568. Epub 2013 Nov 21.
- Therapy-related myeloid neoplasms (t-MN) are a late complication of the successful use of cytotoxic therapy for patients with cancer. A heterozygous deletions of the long arm of chromosome 5 [del(5q)], observed in 40% of patients, is associated with prior exposure to alkylating agents, and a high fr
- PMID 24264229
- Epstein-Barr virus-driven bone marrow aplasia and plasmacytosis mimicking a plasma cell neoplasm.
- Desborough MJ, Grech H.
- British journal of haematology.Br J Haematol.2014 Jan 9. doi: 10.1111/bjh.12721. [Epub ahead of print]
- PMID 24405048
- NF-kappa B mediated Up-regulation of CCCTC-binding factor in pediatric acute lymphoblastic leukemia.
- Zhang H, Zhu L, He H, Zhu S, Zhang W, Liu X, Zhao X, Gao C, Mei M, Bao S, Zheng H.AbstractBACKGROUND: Acute lymphoblastic leukemia (ALL) is the most frequently occurring malignant neoplasm in children. Despite advances in treatment and outcomes for ALL patients, the pathogenesis of the disease remains unclear. Microarray analysis of samples from 100 Chinese children with ALL revealed the up-regulation of CTCF (CCCTC binding factor). CTCF is a highly conserved 11-zinc finger protein that is involved in many human cancers; however, the biological function of CTCF in pediatric ALL is unknown.
- Molecular cancer.Mol Cancer.2014 Jan 7;13(1):5. [Epub ahead of print]
- BACKGROUND: Acute lymphoblastic leukemia (ALL) is the most frequently occurring malignant neoplasm in children. Despite advances in treatment and outcomes for ALL patients, the pathogenesis of the disease remains unclear. Microarray analysis of samples from 100 Chinese children with ALL revealed the
- PMID 24393203
Japanese Journal
- Increased bone marrow uptake of 18F-FDG in leukemia patients: preliminary findings.
Related Links
- Bone marrow neoplasm information including symptoms, causes, diseases, symptoms, treatments, and other medical and health issues. ... Introduction: Bone marrow neoplasm Description of Bone marrow neoplasm Bone marrow ...
- Chronic myelomonocytic leukemia is a disease in which too many myelocytes and monocytes (immature white blood cells) are made in the bone marrow. In chronic myelomonocytic leukemia (CMML), the body tells too many blood ...
Related Pictures
★リンクテーブル★
[★]
- 英
- bone marrow neoplasm
- 関
- 骨髄新生物
[★]
- 英
- bone marrow neoplasm
- 関
- 骨髄腫瘍
[★]
- 関
- benign neoplasm、cancer、neoplasia、neoplastic、onco、oncologic、tumor、tumour
[★]
骨