WordNet

of or relating to or causing bacteriostasis

English Journal

Phase composition control of calcium phosphate nanoparticles for tunable drug delivery kinetics and treatment of osteomyelitis. II. Antibacterial and osteoblastic response.

Uskoković V, Desai TA.Author information Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, California 94158-2330, USA. vuk21@yahoo.comAbstractOsteomyelitis has been traditionally treated by the combination of long-term antibiotic therapies and surgical removal of diseased tissue. The multifunctional material was developed in this study with the aim to improve this therapeutic approach by: (a) enabling locally delivered and sustained release of antibiotics at a tunable rate, so as to eliminate the need for repetitive administration of systemically distributed antibiotics; and (b) controllably dissolving itself, so as to promote natural remineralization of the portion of bone lost to disease. We report hereby on the effect of previously synthesized calcium phosphates (CAPs) with tunable solubilities and drug release timescales on bacterial and osteoblastic cell cultures. All CAP powders exhibited satisfying antibacterial performance against Staphylococcus aureus, the main causative agent of osteomyelitis. Still, owing to its highest drug adsorption efficiency, the most bacteriostatically effective phase was amorphous CAP with the minimal inhibitory concentration of less than 1 mg/mL. At the same time, the positive cell response and osteogenic effect of the antibiotic-loaded CAP particles was confirmed in vitro for all the sparsely soluble CAP phases. Adsorption of the antibiotic onto CAP particles reversed the deleterious effect that the pure antibiotic exerted on the osteogenic activity of the osteoblastic cells. The simultaneous osteogenic and antimicrobial performance of the material developed in this study, altogether with its ability to exhibit sustained drug release, may favor its consideration as a material base for alternative therapeutic approaches to prolonged antibiotic administration and surgical debridement typically prescribed in the treatment of osteomyelitis.
Journal of biomedical materials research. Part A.J Biomed Mater Res A.2013 May;101(5):1427-36. doi: 10.1002/jbm.a.34437. Epub 2012 Oct 31.
Osteomyelitis has been traditionally treated by the combination of long-term antibiotic therapies and surgical removal of diseased tissue. The multifunctional material was developed in this study with the aim to improve this therapeutic approach by: (a) enabling locally delivered and sustained relea
PMID 23115128

Innate immune properties of selected human neuropeptides against Moraxella catarrhalis and nontypeable Haemophilus influenzae.

Augustyniak D, Jankowski A, Mackiewicz P, Skowyra A, Gutowicz J, Drulis-Kawa Z.Author information Department of Pathogen Biology and Immunology, Institute of Genetics and Microbiology, University of Wroclaw, Przybyszewskiego 63/77, 51-148 Wroclaw, Poland. daria.augustyniak@microb.uni.wroc.plAbstractBACKGROUND: Considerable evidence supports the concept of active communication between the nervous and immune systems. One class of such communicators are the neuropeptides (NPs). Recent reports have highlighted the antimicrobial activity of neuropeptides, placing them among the integral components of innate immune defense. This study examined the action of four human neuropeptides: calcitonin gene-related peptide (CGRP), neuropeptide Y (NPY), substance P (SP) and somatostatin (SOM), which are accessible in the upper respiratory tract, against two human-specific respiratory pathogens. We studied: (i) neuropeptide-mediated direct antibacterial activity exerted against Moraxella catarrhalis and nontypeable Haemophilus influenzae, and (ii) indirect immunomodulatory role of these neuropeptides in the neutrophil-mediated phagocytosis of indicated pathogens.
BMC immunology.BMC Immunol.2012 May 2;13:24.
BACKGROUND: Considerable evidence supports the concept of active communication between the nervous and immune systems. One class of such communicators are the neuropeptides (NPs). Recent reports have highlighted the antimicrobial activity of neuropeptides, placing them among the integral components
PMID 22551165

[Antimicrobic features of phenolic lipids].

Nikolaev IuA, Borzenkov IA, Kalinin MV, Loĭko NG, Tarasov AL, Plakunov VK, Beliaev SS, Voronina NV, Gal'chenko VF, El'-Registan GI.AbstractThe connection between the efficiency of phenolic lipids (PL) and their hydrophobic property (solubility) and hydrophobic property of microorganisms' cell structure is shown. The mixture of amphiphilic di(oxiphenil)-phenil-methanes, which act bacteriostatically under 15 mg/l, possesses maximal efficiency against Staphylococcus aureus. Against Mycobacterium smegmatis with hydrophobic cell wall, hydrophobic 2,4-dialkylocibenzol 70 mg/l was the most effective. Hexylresorcin (HR) stops the development of gram-positive bacteria in concentrations 20-50 mg/l, that of gram-negative bacteria in concentration 65 mg/l, that of M. smegmatis at 70 mg/l, and that of yeast and fungi at 300 mg/l. HR prevails bacteria spores germination in the concentration 25-100 mg/l. The dependence of antibacterial action of isomers and homologues of alkylresorcins on their structure--number, position, and length of alkyl substituents--is studied.
Prikladnaia biokhimiia i mikrobiologiia.Prikl Biokhim Mikrobiol.2010 Mar-Apr;46(2):172-9.
The connection between the efficiency of phenolic lipids (PL) and their hydrophobic property (solubility) and hydrophobic property of microorganisms' cell structure is shown. The mixture of amphiphilic di(oxiphenil)-phenil-methanes, which act bacteriostatically under 15 mg/l, possesses maximal effic
PMID 20391760

Japanese Journal

Mode of action of deoxypheganomycin D on Mycobacterium smegmatis ATCC 607.

, , ,
The Journal of Antibiotics 41(5), 675-683, 1988
… 607) bacteriostatically at concentrations as high as 7×10-5M. …
NAID 130003409822

:(1) Streptococcus mutansの発育およびDextransucrase活性に対するNaFの影響

飯田正人,古谷昌裕,岩城正佳,川崎傅男,野崎光洋,佐藤匠
口腔衛生学会雑誌 35(5), 792-797, 1985
NaFは齲蝕予防のためにしばしば臨床に応用されている。この抗齲蝕作用はエナメル質表層のfluoreapatiteやCaF<SUB>2</SUB>形成により歯質を強化し, 耐酸性を向上させるためと考えられている。近年上記の理由の他に口腔齲蝕原性細胞菌の発育や酸産生に対する抑制作用についても検討が加えられている。<BR>そこでわれわれはフッ化物の<I>S …
NAID 130001315364