- 関
- bacteriostatically
WordNet
- of or relating to or causing bacteriostasis
- a chemical or biological material that inhibits bacterial growth
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2015/09/09 21:52:50」(JST)
[Wiki en表示]
A bacteriostatic agent or bacteriostat, abbreviated Bstatic, is a biological or chemical agent that stops bacteria from reproducing, while not necessarily killing them otherwise. Depending on their application, bacteriostatic antibiotics, disinfectants, antiseptics and preservatives can be distinguished. When bacteriostatic antimicrobials are used, the duration of therapy must be sufficient to allow host defense mechanisms to eradicate the bacteria. Upon removal of the bacteriostat, the bacteria usually start to grow again. This is in contrast to bactericides, which kill bacteria.[1]
Bacteriostats are often used in plastics to prevent growth of bacteria on surfaces. Bacteriostats commonly used in laboratory work include sodium azide (which is acutely toxic) and thiomersal (which is a mutagen in mammalian cells).
Bacteriostatic antibiotics
Bacteriostatic antibiotics limit the growth of bacteria by interfering with bacterial protein production, DNA replication, or other aspects of bacterial cellular metabolism. They must work together with the immune system to remove the microorganisms from the body. However, there is not always a precise distinction between them and bactericidal antibiotics; high concentrations of some bacteriostatic agents are also bactericidal, whereas low concentrations of some bacteriocidal agents are bacteriostatic.
This group[2] includes
- Tetracyclines
- Sulfonamides
- Spectinomycin
- Trimethoprim
- Chloramphenicol
- Macrolides
- Lincosamides
- Clindamycin
- Ethambutol
- Nitrofurantoin
- Novobiocin
- Tigecycline
- Oxazolidinone
See also
- List of antibiotics
- Oligodynamic effect
References
- ^ Pankey GA, Sabath LD (March 2004). "Clinical relevance of bacteriostatic versus bactericidal mechanisms of action in the treatment of Gram-positive bacterial infections". Clin. Infect. Dis. 38 (6): 864–70. doi:10.1086/381972. PMID 14999632.
- ^ Shetty N, Aarons E, Andrews J (2009). "Chapter 5: General principles of antimicrobial therapy". In Andrews J, Shetty N, Tang JW. Infectious Disease: Pathogenesis, Prevention and Case Studies. Wiley-Blackwell. ISBN 1-4051-3543-3.
Concepts in pharmacology
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Pharmacokinetics |
- (L)ADME: (Liberation)
- Absorption
- Distribution
- Metabolism
- Excretion (Clearance)
- Loading dose
- Volume of distribution (Initial)
- Rate of infusion
- Compartment
- Bioequivalence
- Bioavailability
- Onset of action
- Biological half-life
- Plasma protein binding
- Therapeutic index (LD50/ED50)
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Pharmacodynamics |
- Toxicity (Neurotoxicology)
- Dose–response relationship (Efficacy, Potency)
- Antimicrobial pharmacodynamics: Minimum inhibitory concentration/Bacteriostatic
- Minimum bactericidal concentration/Bactericide
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Agonism and
antagonism |
- Agonist: Inverse agonist
- Irreversible agonist
- Partial agonist
- Superagonist
- Physiological agonist
- Antagonist: Competitive antagonist
- Irreversible antagonist
- Physiological antagonist
- Other: Binding
- Affinity
- Binding selectivity
- Functional selectivity
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Other |
- Drug tolerance: Tachyphylaxis
- Drug resistance: Antibiotic resistance
- Multiple drug resistance
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Drug discovery
strategies |
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Related
fields/subfields |
- Pharmacogenetics
- Pharmacogenomics
- Neuropsychopharmacology (Neuropharmacology, Psychopharmacology)
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UpToDate Contents
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English Journal
- 2,2'-Dithienyl diselenide pro-oxidant activity accounts for antibacterial and antifungal activities.
- Pesarico AP, Sartori G, Dos Santos CF, Neto JS, Bortolotto V, Santos RC, Nogueira CW, Prigol M.SourceLaboratório de Síntese, Reatividade e Avaliação Farmacológica e Toxicológica de Organocalcogênios, Centro de Ciências Naturais e Exatas, Universidade Federal de Santa Maria, Santa Maria 97105-900, RS, Brazil; Laboratório de Microbiologia, Centro Universitário Franciscano, Conjunto I, UNIFRA, Santa Maria 97010-032, RS, Brazil.
- Microbiological research.Microbiol Res.2013 Nov 7;168(9):563-8. doi: 10.1016/j.micres.2013.04.009. Epub 2013 May 14.
- The aim of this study was to explore if 2,2'-dithienyl diselenide (DTDS) pro-oxidant activity is related to its antibacterial and antifungal actions. The antimicrobial activity of DTDS against bacterial and fungal was investigated in the broth microdilution assay (3.02-387μg/ml). Additionally, the
- PMID 23683588
- Influence of the MBC/MIC ratio on the antibacterial activity of vancomycin versus linezolid against methicillin-resistant Staphylococcus aureus isolates in a pharmacodynamic model simulating serum and soft tissue interstitial fluid concentrations reported in diabetic patients.
- Gonzalez N, Sevillano D, Alou L, Cafini F, Gimenez MJ, Gomez-Lus ML, Prieto J, Aguilar L.SourceMicrobiology Unit, Medicine Department, School of Medicine, Universidad Complutense, Avda. Complutense s/n, 28040 Madrid, Spain.
- The Journal of antimicrobial chemotherapy.J Antimicrob Chemother.2013 Oct;68(10):2291-5. doi: 10.1093/jac/dkt185. Epub 2013 May 14.
- OBJECTIVES: To explore serum and tissue pharmacodynamics of linezolid versus vancomycin against methicillin-resistant Staphylococcus aureus (MRSA) clinical isolates with different MBC/MIC ratios.METHODS: Five strains (vancomycin MIC/MBCs, mg/L) were used: TOL-1 (2/≥64), TOL-2 (1/16), LT-1 and LT-2
- PMID 23674766
- Tris-EDTA significantly enhances antibiotic efficacy against multidrug-resistant Pseudomonas aeruginosa in vitro.
- Buckley LM, McEwan NA, Nuttall T.SourceSchool of Veterinary Science, The University of Liverpool, Leahurst Campus, Neston, Cheshire, CH64 7TE, UK.
- Veterinary dermatology.Vet Dermatol.2013 Oct;24(5):519-e122. doi: 10.1111/vde.12071.
- BACKGROUND: Multidrug-resistant Pseudomonas aeruginosa commonly complicates chronic bacterial otitis in dogs.HYPOTHESIS/OBJECTIVES: The aim of this in vitro study was to determine the effect of ethylenediaminetetraacetic acid-tromethamine (Tris-EDTA) on the minimal bactericidal concentrations (MBCs)
- PMID 24025021
Japanese Journal
- Enhanced Inactivation of Bacillus subtilis Spores by Carbonation with Heating in the Presence of Monoglycerol-caprate
- Development of Interpreting System for Antimicrobial Susceptibility Testing by the Disc Diffusion Technique(Internet and Applications・3,Internet Architecture and Applications)
Related Links
- Our company is a leading supplier of Hospira Bacteriostatic Water, which contains 0.9% benzyl alcohol as a bacteriostatic preservative. Buy wholesale Sterile Water for Injection and empty sterile vials for sale online.
- Bacteriostatic definition, the prevention of the further growth of bacteria. See more. Thesaurus Translate Puzzles & Games Reference Word of the Day Blog Slideshows Apps by Dictionary My Account Log Out Log In Dictionary ...
Related Pictures
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★リンクテーブル★
[★]
- 英
- bacteriostatic、bacteriostatically
- 関
- 静菌性
[★]
- 英
- bacteriostatic
- 関
- 静菌的
[★]
- 関
- bacteriostatic