aspartate-tRNA ligase

アスパラギン酸tRNAリガーゼ

関

aspartyl-tRNA synthetase

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/07/05 15:10:50」(JST)

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aspartate-tRNA ligase
Identifiers
EC number	6.1.1.12
CAS number	9027-32-1
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / EGO
Search PMC articles PubMed articles NCBI proteins

In enzymology, an aspartate-tRNA ligase (EC 6.1.1.12) is an enzyme that catalyzes the chemical reaction

ATP + L-aspartate + tRNAAsp $\rightleftharpoons$ AMP + diphosphate + L-aspartyl-tRNAAsp

The 3 substrates of this enzyme are ATP, L-aspartate, and tRNA(Asp), whereas its 3 products are AMP, diphosphate, and L-aspartyl-tRNA(Asp).

This enzyme belongs to the family of ligases, to be specific those forming carbon-oxygen bonds in aminoacyl-tRNA and related compounds. The systematic name of this enzyme class is L-aspartate:tRNAAsp ligase (AMP-forming). Other names in common use include aspartyl-tRNA synthetase, aspartyl ribonucleic synthetase, aspartyl-transfer RNA synthetase, aspartic acid translase, aspartyl-transfer ribonucleic acid synthetase, and aspartyl ribonucleate synthetase. This enzyme participates in alanine and aspartate metabolism and aminoacyl-trna biosynthesis.

Structural studies

As of late 2007, 10 structures have been solved for this class of enzymes, with PDB accession codes 1ASY, 1ASZ, 1B8A, 1C0A, 1EFW, 1EOV, 1EQR, 1G51, 1IL2, and 1L0W.

See also

• DARS (gene)

References

• Gangloff J, Dirheimer G (1973). "Studies on aspartyl-tRNA synthetase from Baker's yeast. I Purification and properties of the enzyme". Biochim. Biophys. Acta 294 (1): 263–72. doi:10.1016/0005-2787(73)90298-0. PMID 4575961. 
• NORTON SJ, RAVEL JM, LEE C, SHIVE W (1963). "Purification and properties of the aspartyl ribonucleic acid synthetase of Lactobacillus arabinosus". J. Biol. Chem. 238: 269–74. PMID 13939000. 

UpToDate Contents

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English Journal

• Protein identification in two phases of 1,3-propanediol production by proteomic analysis.

• Comba González N, Vallejo AF, Sánchez-Gómez M, Montoya D.SourceBioprocesses and Bioprospecting Group, Biotechnology Institute, Universidad Nacional de Colombia, Bogotá, Colombia.
• Journal of proteomics.J Proteomics.2013 Aug 26;89:255-64. doi: 10.1016/j.jprot.2013.06.011. Epub 2013 Jun 28.
• Proteomic analysis by two-dimensional electrophoresis (2D)-mass spectrometry was used to identify differentially expressed proteins in the Clostridium sp. native strain (IBUN 158B) in two phases of the 1,3-propanediol (1,3-PD) production (lag phase and exponential growth phase). Intracellular protei
• PMID 23811541

• Patients with non-Jo-1 anti-RNA-synthetase autoantibodies have worse survival than Jo-1 positive patients.

• Hervier B, Devilliers H, Benveniste O.KEYWORDS: Adult Onset Still's Disease, Amyloidosis, Analgesics
• Annals of the rheumatic diseases.Ann Rheum Dis.2013 Jul;72(7):e18. doi: 10.1136/annrheumdis-2013-203605. Epub 2013 May 5.
• PMID 23644669

• Mutations in DARS cause hypomyelination with brain stem and spinal cord involvement and leg spasticity.

• Taft RJ, Vanderver A, Leventer RJ, Damiani SA, Simons C, Grimmond SM, Miller D, Schmidt J, Lockhart PJ, Pope K, Ru K, Crawford J, Rosser T, de Coo IF, Juneja M, Verma IC, Prabhakar P, Blaser S, Raiman J, Pouwels PJ, Bevova MR, Abbink TE, van der Knaap MS, Wolf NI.SourceInstitute for Molecular Bioscience, University of Queensland, St. Lucia, Queensland 4072, Australia. r.taft@imb.uq.edu.au
• American journal of human genetics.Am J Hum Genet.2013 May 2;92(5):774-80. doi: 10.1016/j.ajhg.2013.04.006.
• Inherited white-matter disorders are a broad class of diseases for which treatment and classification are both challenging. Indeed, nearly half of the children presenting with a leukoencephalopathy remain without a specific diagnosis. Here, we report on the application of high-throughput genome and
• PMID 23643384

Related Links

• DARS - Aspartate--tRNA ligase, cytoplasmic - Homo sapiens ...

Aspartate--tRNA ligase, cytoplasmic (EC:6.1.1.12) Alternative name(s): Aspartyl-tRNA synthetase Short name: AspRS Cell proliferation-inducing gene 40 protein Gene names i Name:DARS ORF Names: PIG40 Organism i i 9606 ...

• aspS - Aspartate--tRNA ligase - Escherichia coli (strain K12)

<p>An evidence describes the source of an annotation, e.g. an experiment that has been published in the scientific literature, an orthologous protein, a record from another database, etc.</p> <p><a href="/manual/evidences">More ...

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★リンクテーブル★

リンク元	「aspartyl-tRNA synthetase」「アスパラギン酸tRNAリガーゼ」
関連記事	「aspartate」「tRNA」「ligase」「tRNAs」「tRNA ligase」

「aspartyl-tRNA synthetase」

　　[★]

アスパルチルtRNA合成酵素、アスパルチルtRNAシンテターゼ

関

aspartate-tRNA ligase

「アスパラギン酸tRNAリガーゼ」

　　[★]

英

aspartate-tRNA ligase

関

アスパルチルtRNA合成酵素

「aspartate」

　　[★] アスパラギン酸、アスパラギン酸塩

関

Asp、aspartic、aspartic acid、D、L-aspartate、L-aspartic acid、magnesium aspartate、potassium aspartate

aspartic acid

「tRNA」

　　[★] トランスファーRNA, transfer RNA, 転位RNA

「ligase」

　　[★]

リガーゼ、連結酵素

関

synthetase

「tRNAs」

　　[★] トランスファーRNA transfer RNAs

「tRNA ligase」

　　[★]

tRNAリガーゼ

関

RNA ligase