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1. 低リスク妊娠性絨毛腫瘍の初期マネージメント initial management of low risk gestational trophoblastic neoplasia
2. 抵抗性または再発性の妊娠性絨毛腫瘍のマネージメント management of resistant or recurrent gestational trophoblastic neoplasia
3. ユーイング肉腫ファミリーの腫瘍の治療 treatment of the ewing sarcoma family of tumors
4. 肝疾患を有する患者における化学療法による肝毒性および用量調整 chemotherapy hepatotoxicity and dose modification in patients with liver disease
5. 高リスク妊娠性絨毛腫瘍の初期マネージメント initial management of high risk gestational trophoblastic neoplasia

Apoptosis induced by NAD depletion is inhibited by KN-93 in a CaMKII-independent manner.

Takeuchi M1, Yamamoto T2.
Experimental cell research.Exp Cell Res.2015 Jul 1;335(1):62-7. doi: 10.1016/j.yexcr.2015.05.019. Epub 2015 May 27.
Nicotinamide phosphoribosyltransferase (NAMPT) is a key enzyme that catalyzes the synthesis of nicotinamide mononucleotide from nicotinamide (Nam) in the salvage pathway of mammalian NAD biosynthesis. Several potent NAMPT inhibitors have been identified and used to investigate the role of intracellu
PMID 26024774

Imaging of nucleolar RNA in living cells using a highly photostable deep-red fluorescent probe.

Zhou B1, Liu W1, Zhang H1, Wu J1, Liu S1, Xu H1, Wang P2.
Biosensors & bioelectronics.Biosens Bioelectron.2015 Jun 15;68:189-96. doi: 10.1016/j.bios.2014.12.055. Epub 2014 Dec 26.
A new crescent-shape fluorescent probe (named here as CP) that selectively stains RNA in nucleoli of living cells is prepared. CP shows a deep-red emission (658 nm) and a large Stokes shift because of the introduction of rigid-conjugated coumarin moiety into the molecular structure. Cell imaging exp
PMID 25569876

Gilbert B1, Ahmad K1, Roos J1, Lehmann C2, Chiba T3, Ulrich-Rückert S1, Smeenk L4, van Heeringen S5, Maier T1, Groner B6, Steinhilber D7.
Biochimica et biophysica acta.Biochim Biophys Acta.2015 Jun 9. pii: S1874-9399(15)00124-8. doi: 10.1016/j.bbagrm.2015.06.004. [Epub ahead of print]
The p53 tumor suppressor plays a critical role in cancer, and more than 50% of human tumors contain mutations or deletions of the TP53 gene. p53 can transactivate or repress target genes in response to diverse stress signals, such as transient growth arrest, DNA repair, cellular differentiation, sen
PMID 26070487