関: euflavine

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/08/01 21:05:45」(JST)

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Acriflavine is a topical antiseptic. It has the form of an orange or brown powder. It may be harmful in the eyes or if inhaled. It is a dye and it stains the skin and may irritate. The hydrochloride form is more irritating than the neutral form. It is derived from acridine.

Commercial preparations are often mixtures with proflavine. It is known by a variety of commercial names.

Acriflavine was developed in 1912 by Paul Ehrlich, a German medical researcher, and was used during the First World War against sleeping sickness.^[1]

Acriflavine is also used as treatment for external fungal infections of aquarium fish.^[2]

Acriflavine has been shown to have anti-cancer activity by inhibition of HIF-1 which prevents blood vessels growing to supply tumors with blood and interferes with glucose uptake and use.^[3]

Legal status

USA, Europe, Canada

Australia

Acriflavine is a controlled substance in Australia and dependent on situation,^{[clarification needed]} is considered either a Schedule 5 (Caution) or Schedule 7 (Dangerous Poison) substance. The use, storage and preparation of the chemical is subject to strict state and territory laws.^{[citation needed]}

References

^ acriflavine(Encyclopædia Britannica)
^ Acriflavine use in aquaria
^ Lee, K.; Zhang, H.; Qian, D. Z.; Rey, S.; Liu, J. O.; Semenza, G. L. (2009). "Acriflavine inhibits HIF-1 dimerization, tumor growth, and vascularization". Proceedings of the National Academy of Sciences 106 (42): 17910. doi:10.1073/pnas.0909353106.

External links

ChemExper Chemical Directory (accessed 2005-08-16)

UpToDate Contents

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1. 共焦点レーザー内顕微鏡検査および超拡大内視鏡 confocal laser endomicroscopy and endocytoscopy

English Journal

Characterization of Erysipelothrix rhusiopathiae strains isolated from acute swine erysipelas outbreaks in Eastern China.

Zou Y1, Zhu X, Muhammad HM, Jiang P, Li Y.
The Journal of veterinary medical science / the Japanese Society of Veterinary Science.J Vet Med Sci.2015 Jul 1;77(6):653-60. doi: 10.1292/jvms.14-0589. Epub 2015 Feb 3.
Recently, a series of acute swine erysipelas outbreaks occurred in Eastern China. Eight strains isolated from cases of septicemia were determined as serotype 1a, and 4 of the isolates were resistant to acriflavine. One isolate strain named HX130709 was attenuated on agar media containing acriflavine
PMID 25649849

Single-step multiresidue determination of ten multiclass veterinary drugs in pork, milk, and eggs using liquid chromatography with tandem mass spectrometry.

Park JA1, Zhang D1, Kim DS1, Kim SK1, Cho KS1, Jeong D1, Shim JH2, Kim JS1, El-Aty AM1,3, Shin HC1.
Journal of separation science.J Sep Sci.2015 May 29. doi: 10.1002/jssc.201500501. [Epub ahead of print]
A multiclass, multiresidue determination method is reported for the detection of ten veterinary drugs, including scopolamine, metoclopramide, acriflavine, berberine, tripelennamine, diphenhydramine, acrinol, triamcinolone, loperamide, and roxithromycin in pork, milk, and eggs. The method involves a
PMID 26033853

A quantitative microscopic approach to predict local recurrence based on in vivo intraoperative imaging of sarcoma tumor margins.

Mueller JL1, Fu HL1, Mito JK2, Whitley MJ2, Chitalia R1, Erkanli A3, Dodd L4, Cardona DM5, Geradts J5, Willett RM6, Kirsch DG2,7, Ramanujam N1.
International journal of cancer. Journal international du cancer.Int J Cancer.2015 May 20. doi: 10.1002/ijc.29611. [Epub ahead of print]
The goal of resection of soft tissue sarcomas located in the extremity is to preserve limb function while completely excising the tumor with a margin of normal tissue. With surgery alone, one-third of patients with soft tissue sarcoma of the extremity will have local recurrence due to microscopic re
PMID 25994353

Japanese Journal

Mechanisms of action of acriflavine : electron microscopic study of cell wall changes induced in Staphylococcus aureus by acriflavine

KAWAI Mako,YAMAGISHI Jun-icni
Microbiology and immunology 53(9), 481-486, 2009-09-20
NAID 10027687311

Acriflavine inhibits HIF-1 dimerization, tumor growth, and vascularization

LEE K
Proc Natl Acad Sci USA 106, 17910-17915, 2009
NAID 80020635444

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★リンクテーブル★

リンク元	「acquired B」「アクリフラビン」「euflavine」

「acquired B」

Acriflavinium chloride
	; Pure acriflavinium chloride
Names
	IUPAC name 3,6-Diamino-10-methylacridin-10-ium chloride
Identifiers
CAS Number	65589-70-0 ; 10597-46-3 (HCl)
ChEBI	CHEBI:383703
ChEMBL	ChEMBL354349
ChemSpider	391386 ; 21018 (HCl)
EC Number	201-668-8
Jmol 3D model	Interactive image; Interactive image
PubChem	443101; 15558347 (HCl)
UNII	1S73VW819C
	InChI InChI=1S/C14H13N3.ClH/c1-17-13-7-11(15)4-2-9(13)6-10-3-5-12(16)8-14(10)17;/h2-8H,1H3,(H3,15,16);1H Key: KKAJSJJFBSOMGS-UHFFFAOYSA-N ; InChI=1S/C14H13N3.C13H11N3.ClH/c1-17-13-7-11(15)4-2-9(13)6-10-3-5-12(16)8-14(10)17;14-10-3-1-8-5-9-2-4-11(15)7-13(9)16-12(8)6-10;/h2-8H,1H3,(H3,15,16);1-7H,14-15H2;1H Key: PEJLNXHANOHNSU-UHFFFAOYSA-N ; Key: PEJLNXHANOHNSU-UHFFFAOYSA-N ;
	SMILES [Cl-].C[N+]1=C2C=C(N)C=CC2=CC2=C1C=C(N)C=C2 ; [Cl-].n1c3c(cc2c1cc(N)cc2)ccc(c3)N.Nc3cc2[n+](c1cc(N)ccc1cc2cc3)C ;
Properties
Chemical formula	C14H14ClN3
Molar mass	259.74 g·mol−1
Pharmacology
ATC code	R02AA13 (WHO) QG01AC90 (WHO)
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
	verify (what is ?)
	Infobox references

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関: ABO式血液型検査

A型の人の赤血球が細菌感染によって抗Bと弱い凝集反応をすること。A抗原のN-acetylgalactosamineからアセチル基が細菌酵素によって切断されるために生じる。又は赤血球が抗B血清の着色色素acriflavineと反応して凝集する現象。(参考1より引用)

参考

1.

http://homepage2.nifty.com/cryomedicine/wdA_C.htm

2.

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1989801/

3.

http://www.yuketsu.gr.jp/gakkaishi/49-1/049010050.pdf

「アクリフラビン」

　　[★]

英: acriflavine
同: トリパフラビン trypaflavine
関: ユーフラビン、アクリジン、トリパノソーマ

「euflavine」

　　[★]

ユーフラビン

関: acriflavine

[EB-1] riflavine(Encyclopædia Britannica)

[2] Acriflavine use in aquaria

[3] Lee, K.; Zhang, H.; Qian, D. Z.; Rey, S.; Liu, J. O.; Semenza, G. L. (2009). "Acriflavine inhibits HIF-1 dimerization, tumor growth, and vascularization". Proceedings of the National Academy of Sciences 106 (42): 17910. doi:10.1073/pnas.0909353106.

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案内

acriflavine