WordNet

a way of doing something, especially a systematic way; implies an orderly logical arrangement (usually in steps)
United States novelist (1862-1937) (同)Edith Wharton, Edith Newbold Jones Wharton

PrepTutorEJDIC

〈C〉(特に秩序だった)(…の)『方法』,方式《+『of』+『名』(do『ing』)》 / 〈C〉〈U〉(思考行・行為・行動の)きちょうめんさ;秩序,筋道

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1. 乳幼児および思春期前の小児における通常の成長パターン normal growth patterns in infants and prepubertal children
2. 在胎月齢の生後評価 postnatal assessment of gestational age
3. Fertility awareness法での避妊 fertility awareness based methods of pregnancy prevention
4. 低身長の小児および思春期患者に対する診断的アプローチ diagnostic approach to children and adolescents with short stature
5. 腰痛の運動療法 exercise based therapy for low back pain

English Journal

A nanoscaffold impregnated with human wharton's jelly stem cells or its secretions improves healing of wounds.

Tam K1, Cheyyatraviendran S, Venugopal J, Biswas A, Choolani M, Ramakrishna S, Bongso A, Fong CY.Author information 1Department of Obstetrics and Gynaecology, Yong Yoo Lin School of Medicine, National University Health System, National University of Singapore, Kent Ridge, Singapore, 119228, Singapore.AbstractWound healing is a major problem in diabetic patients and current methods of treatment have met with limited success. Since skin cell renewal is under the control of mesenchymal stem cells (MSCs) treatment of wounds has been attempted with the application of exogenous bone marrow MSCs (hBMMSCs). However, hBMMSCs have the limitations of painful harvest, low cell numbers and short-lived stemness properties unlike MSCs from the Wharton's jelly of human umbilical cords (hWJSCs). Since nanoscaffolds provide three dimensional architectural patterns that mimic in vivo stem cell niches and aloe vera has antibacterial properties we evaluated the use of an aloe vera-polycaprolactone (AV/PCL) nanoscaffold impregnated with green fluorescent protein (GFP)-labeled hWJSCs (GFP-hWJSCs + AV/PCL) or its conditioned medium (hWJSC-CM + AV/PCL) for healing of excisional and diabetic wounds. In skin fibroblast scratch-wound assays exposed to GFP-hWJSCs + AV/PCL or hWJSC-CM + AV/PCL, fibroblasts migrated significantly faster from edges of scratches into vacant areas together with increased secretion of collagen I and III, elastin, fibronectin, superoxide dismutase, and metalloproteinase-1 (MMP-1) compared to controls. After one application of GFP-hWJSCs + AV/PCL or hWJSC-CM + AV/PCL excisional and diabetic wounds in mice showed rapid wound closure, reepithelialization, and increased numbers of sebaceous glands and hair follicles compared to controls. The same wounds exposed to GFP-hWJSCs + AV/PCL or hWJSC-CM + AV/PCL also showed positive keratinocyte markers (cytokeratin, involucrin, filaggrin) and increased expression of ICAM-1, TIMP-1, and VEGF-A compared to controls. AV/PCL nanoscaffolds in combination with hWJSCs appear to have synergistic benefits for wound healing.
Journal of cellular biochemistry.J Cell Biochem.2014 Apr;115(4):794-803. doi: 10.1002/jcb.24723.
Wound healing is a major problem in diabetic patients and current methods of treatment have met with limited success. Since skin cell renewal is under the control of mesenchymal stem cells (MSCs) treatment of wounds has been attempted with the application of exogenous bone marrow MSCs (hBMMSCs). How
PMID 24265214

Brain haemosiderin in older people: pathological evidence for an ischaemic origin of magnetic resonance imaging (MRI) microbleeds.

Janaway BM1, Simpson JE, Hoggard N, Highley JR, Forster G, Drew D, Gebril OH, Matthews FE, Brayne C, Wharton SB, Ince PG; MRC Cognitive Function and Ageing Neuropathology Study.Author information 1Sheffield Institute for Translational Neuroscience, University of Sheffield, Sheffield, UK.AbstractINTRODUCTION: Magnetic resonance imaging (MRI) cerebral microbleeds (CMB) arise from ferromagnetic haemosiderin iron assumed to derive from extravasation of erythrocytes. Light microscopy of ageing brain frequently reveals foci of haemosiderin from single crystalloids to larger, predominantly perivascular, aggregates. The pathological and radiological relationship between these findings is not resolved.
Neuropathology and applied neurobiology.Neuropathol Appl Neurobiol.2014 Apr;40(3):258-69. doi: 10.1111/nan.12062.
INTRODUCTION: Magnetic resonance imaging (MRI) cerebral microbleeds (CMB) arise from ferromagnetic haemosiderin iron assumed to derive from extravasation of erythrocytes. Light microscopy of ageing brain frequently reveals foci of haemosiderin from single crystalloids to larger, predominantly periva
PMID 23678850

External validation of multivariable prediction models: a systematic review of methodological conduct and reporting.

Collins GS1, de Groot JA, Dutton S, Omar O, Shanyinde M, Tajar A, Voysey M, Wharton R, Yu LM, Moons KG, Altman DG.Author information 1Centre for Statistics in Medicine, Botnar Research Centre, University of Oxford, Windmill Road, Oxford OX3 7LD, UK. gary.collins@csm.ox.ac.uk.AbstractBACKGROUND: Before considering whether to use a multivariable (diagnostic or prognostic) prediction model, it is essential that its performance be evaluated in data that were not used to develop the model (referred to as external validation). We critically appraised the methodological conduct and reporting of external validation studies of multivariable prediction models.
BMC medical research methodology.BMC Med Res Methodol.2014 Mar 19;14(1):40. doi: 10.1186/1471-2288-14-40.
BACKGROUND: Before considering whether to use a multivariable (diagnostic or prognostic) prediction model, it is essential that its performance be evaluated in data that were not used to develop the model (referred to as external validation). We critically appraised the methodological conduct and re
PMID 24645774

Japanese Journal

97(P-30) 新規Caspase-1阻害天然物Pentenocin類の合成と絶対構造の決定(ポスター発表の部)

菅原勉,福田隼,岩渕好治
天然有機化合物討論会講演要旨集 (45), 573-578, 2003-09-01
… To synthesize (±)-pentenocin B 5 or 6, the mixture of the 1,4-diols 10a and 10b was converted to the α,β-unsaturated ketones 18a and 18b via a Wharton rearrangement. … The (R)-stereochemistry of the C-6 secondary alcohol in (+)-pentenocin B 3 was determined using the modified Mosher method and the X-ray analysis. …
NAID 110006682356

シクロプロパン環の開裂反応を利用した生理活性天然有機化合物の合成研究

谷森紳治,谷森紳治
Bulletin of the University of Osaka Prefecture. Ser. B, Agriculture and biology 43, 123-181, 1991-03-31
… The cleavage reaction of cyclopropane ring is one of the useful method in organic synthesis. … 1, 3-Carbonyl transposition of 168 using Wharton rearrangement afforded ketone (174). …
NAID 110004789021