関: Tropheryma whipplei

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/05/23 03:32:16」(JST)

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Tropheryma whipplei, formerly called Tropheryma whippelii,^[1] is a bacterium and the causative organism of Whipple's disease^[2] and rarely endocarditis.

While T. whipplei is categorized with the Gram-positive Actinobacteria, the organism is commonly found to be Gram-negative or Gram-indeterminate when stained in the laboratory.^[2] Whipple himself probably observed the organisms as rod-shaped structures with silver stain in his original case.^[3]

History of the name

No name was given to the organism until 1991 when the name Tropheryma^[4] whippelii was proposed after sections of the bacterial genome were sequenced.^[5] The name was changed to Tropheryma whipplei in 2001 (correcting the spelling of Whipple's name) when the organism was deposited in bacterial collections.^[2]

Pathogenesis

Genome structure

Several strains of Tropheryma whipplei have been sequenced.^[6]^[7]

References

^ Liang Z, La Scola B, Raoult D; La Scola; Raoult (January 2002). "Monoclonal antibodies to immunodominant epitope of Tropheryma whipplei". Clin. Diagn. Lab. Immunol. 9 (1): 156–9. doi:10.1128/CDLI.9.1.156-159.2002. PMC 119894. PMID 11777846.
^ ^a ^b ^c La Scola B, Fenollar F, Fournier PE, Altwegg M, Mallet MN, Raoult D; Fenollar; Fournier; Altwegg; Mallet; Raoult (July 2001). "Description of Tropheryma whipplei gen. nov., sp. nov., the Whipple's disease bacillus". Int. J. Syst. Evol. Microbiol. 51 (Pt 4): 1471–9. PMID 11491348.
^ Whipple GH. (1907). "A hitherto undescribed disease characterized anatomically by deposits of fat and fatty acids in the intestinal and mesenteric lymphatic tissues". Johns Hopkins Hosp Bull 18: 382–91.
^ From Greek τροφή trophê, "nourishment, food" and ἔρυμα eruma, "fence, a defence against, barrier".
^ Relman D, Schmidt T, MacDermott R, Falkow S; Schmidt; MacDermott; Falkow (1992). "Identification of the uncultured bacillus of Whipple's disease". N Engl J Med 327 (5): 293–301. doi:10.1056/NEJM199207303270501. PMID 1377787.
^ Raoult D, et al. (2003). "Tropheryma whipplei Twist: a human pathogenic Actinobacteria with a reduced genome". Genome Res 13 (8): 1800–9. doi:10.1101/gr.1474603 (inactive 2015-02-01). PMC 403771. PMID 12902375.
^ Bentley, SD.; Maiwald, M.; Murphy, LD.; Pallen, MJ.; Yeats, CA.; Dover, LG.; Norbertczak, HT.; Besra, GS.; et al. (Feb 2003). "Sequencing and analysis of the genome of the Whipple's disease bacterium Tropheryma whipplei". Lancet 361 (9358): 637–44. doi:10.1016/S0140-6736(03)12597-4. PMID 12606174.

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English Journal

Relapsing Whipple's disease: a case report and literature review.

Ruggiero E1, Zurlo A, Giantin V, Galeazzi F, Mescoli C, Nante G, Petruzzellis F, Manzato E.
European journal of gastroenterology & hepatology.Eur J Gastroenterol Hepatol.2015 Dec 8. [Epub ahead of print]
Whipple's disease is a rare infection caused by Tropheryma whipplei, a Gram-negative Bacillus usually found in macrophages of the lamina propria of the small intestine. The typical clinical manifestations of classic Whipple's disease are diarrhea, weight loss, malabsorption, abdominal pain, and arth
PMID 26649803

Airway dysbiosis: Haemophilus influenzae and Tropheryma in poorly controlled asthma.

Simpson JL1, Daly J2, Baines KJ3, Yang IA4, Upham JW5, Reynolds PN6, Hodge S6, James AL7, Hugenholtz P2, Willner D2, Gibson PG8.
The European respiratory journal.Eur Respir J.2015 Dec 2. pii: ERJ-00405-2015. doi: 10.1183/13993003.00405-2015. [Epub ahead of print]
Asthma is a chronic inflammatory disorder of the airways where bacteria may act as protagonists of chronic inflammation. Little is known about the relation of airway inflammation to the presence of specific bacterial taxa. We sought to describe the sputum microbiome in adults with poorly controlled
PMID 26647445

Tropheryma whipplei Endocarditis: A Two-patient Case Series.

Borne RT1, Babu A2, Levi M3, Brieke A1, Quaife RA4.
The American journal of medicine.Am J Med.2015 Dec;128(12):1364-6. doi: 10.1016/j.amjmed.2015.06.053. Epub 2015 Jul 31.
BACKGROUND: Whipple endocarditis is caused by Tropheryma whipplei and is a well-described complication of Whipple's disease. Limited and small case series have been published regarding the presentation, diagnosis, and clinical course of this disease.METHODS/RESULTS: We describe 2 cases of patients w
PMID 26239095

Japanese Journal

電子顕微鏡所見とPCR法で確診したWhipple病の1例

日本消化器病学会雑誌 113(11), 1894-1900, 2016
NAID 130005277809

Whipple Disease Diagnosed with PCR Using Formalin-fixed Paraffin-embedded Specimens of the Intestinal Mucosa

Internal Medicine 52(2), 219-222, 2013
NAID 130003365854

Central Nervous System Relapse of Whipple's Disease

Internal Medicine 51(15), 2045-2050, 2012
NAID 130002062266

「トロフェリマ属」

Tropheryma whipplei
Scientific classification
Kingdom:	Bacteria
Phylum:	Actinobacteria
Class:	Actinobacteria
Subclass:	Actinobacteridae
Order:	Actinomycetales
Family:	Cellulomonadaceae
Genus:	Tropheryma
Species:	T. whipplei
Binomial name
	Tropheryma whipplei; La Scola et al. 2001

　　[★]

ラ: Tropheryma
関: トロフェリマ・ウィッペリ

「Tropheryma whipplei」

　　[★]

日: トロフェリマ・ウィッペリ
ラ: Tropheryma whipplei
関: ウィップル病、トロフェリマ属

[show details]

トロフェリマ・ウィッペリ : 10 件
トロフェリマ・ホウィッペリ : 6 件
トロフェリマ・ホウィップリ : 7 件

[1] Liang Z, La Scola B, Raoult D; La Scola; Raoult (January 2002). "Monoclonal antibodies to immunodominant epitope of Tropheryma whipplei". Clin. Diagn. Lab. Immunol. 9 (1): 156–9. doi:10.1128/CDLI.9.1.156-159.2002. PMC 119894. PMID 11777846.

[La_Scola_2001-2] La Scola B, Fenollar F, Fournier PE, Altwegg M, Mallet MN, Raoult D; Fenollar; Fournier; Altwegg; Mallet; Raoult (July 2001). "Description of Tropheryma whipplei gen. nov., sp. nov., the Whipple's disease bacillus". Int. J. Syst. Evol. Microbiol. 51 (Pt 4): 1471–9. PMID 11491348.

[3] Whipple GH. (1907). "A hitherto undescribed disease characterized anatomically by deposits of fat and fatty acids in the intestinal and mesenteric lymphatic tissues". Johns Hopkins Hosp Bull 18: 382–91.

[4] From Greek τροφή trophê, "nourishment, food" and ἔρυμα eruma, "fence, a defence against, barrier".

[5] Relman D, Schmidt T, MacDermott R, Falkow S; Schmidt; MacDermott; Falkow (1992). "Identification of the uncultured bacillus of Whipple's disease". N Engl J Med 327 (5): 293–301. doi:10.1056/NEJM199207303270501. PMID 1377787.

[6] Raoult D, et al. (2003). "Tropheryma whipplei Twist: a human pathogenic Actinobacteria with a reduced genome". Genome Res 13 (8): 1800–9. doi:10.1101/gr.1474603 (inactive 2015-02-01). PMC 403771. PMID 12902375.

[7] Bentley, SD.; Maiwald, M.; Murphy, LD.; Pallen, MJ.; Yeats, CA.; Dover, LG.; Norbertczak, HT.; Besra, GS.; et al. (Feb 2003). "Sequencing and analysis of the genome of the Whipple's disease bacterium Tropheryma whipplei". Lancet 361 (9358): 637–44. doi:10.1016/S0140-6736(03)12597-4. PMID 12606174.

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Tropheryma