WordNet

make a map of; show or establish the features of details of; "map the surface of Venus"
to establish a mapping (of mathematical elements or sets) (同)represent
a diagrammatic representation of the earths surface (or part of it)
plan, delineate, or arrange in detail; "map ones future" (同)map out
depict as if on a map; "sorrow was mapped on the mothers face"
explore or survey for the purpose of making a map; "We havent even begun to map the many galaxies that we know exist"
locate within a specific region of a chromosome in relation to known DNA or gene sequences; "map the genes"
the 13th letter of the Roman alphabet (同)m
an enzyme that catalyzes the conversion of a proenzyme to an active enzyme

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Ying H1, DePinho RA2.
Cell research.Cell Res.2014 Nov;24(11):1282-3. doi: 10.1038/cr.2014.103. Epub 2014 Aug 8.
The propagation of kinase-mediated phosphorylation signals is central to the oncogenic activity of the RAS-MAPK pathway in human cancers. A recent study shows that protein lysine methylation controls the phosphorylation status of a key component of the RAS-MAPK pathway to enable oncogenic KRAS in ca
PMID 25104733

Obatoclax overcomes resistance to cell death in aggressive thyroid carcinomas by countering Bcl2a1 and Mcl1 overexpression.

Champa D1, Russo MA1, Liao XH1, Refetoff S2, Ghossein RA1, Di Cristofano A3.
Endocrine-related cancer.Endocr Relat Cancer.2014 Oct;21(5):755-67. doi: 10.1530/ERC-14-0268. Epub 2014 Jul 10.
Poorly differentiated tumors of the thyroid gland (PDTC) are generally characterized by a poor prognosis due to their resistance to available therapeutic approaches. The relative rarity of these tumors is a major obstacle to our understanding of the molecular mechanisms leading to tumor aggressivene
PMID 25012986

Restoration of miR17/20a in solid tumor cells enhances the natural killer cell antitumor activity by targeting Mekk2.

Jiang H1, Wang P2, Li X3, Wang Q4, Deng ZB4, Zhuang X4, Mu J4, Zhang L4, Wang B4, Yan J4, Miller D4, Zhang HG5.
Cancer immunology research.Cancer Immunol Res.2014 Aug;2(8):789-99. doi: 10.1158/2326-6066.CIR-13-0162. Epub 2014 May 6.
Aberrant microRNA (miRNA) expression has been identified in various human solid cancers. However, whether the levels of miRNA expression in tumor cells have any effect on tumor progression has not been determined. In this proof-of-concept study, the restoration of high-level expression of the miR17-
PMID 24801835

Methylglyoxal activates the target of rapamycin complex 2-protein kinase C signaling pathway in Saccharomyces cerevisiae.

Nomura Wataru,Inoue Yoshiharu
Molecular and cellular biology 35(7), 1269-1280, 2015-04
… We show here that methylglyoxal activates the Pkc1-Mpk1 mitogen-activated protein (MAP) kinase cascade in a target of rapamycin complex 2 (TORC2)-dependent manner in the budding yeast Saccharomyces cerevisiae. … Methylglyoxal enhanced the phosphorylation of Pkc1 at Ser(1143), which transmitted the signal to the downstream Mpk1 MAP kinase cascade. …
NAID 120005615637

Geranylgeranyltransferase Cwg2-Rho4/Rho5 module is implicated in the Pmk1 MAP kinase-mediated cell wall integrity pathway in fission yeast

Doi Akira,Kita Ayako,Kanda Yuki,Uno Takaya,Asami Keita,Satoh Ryosuke,Nakano Kentaro,Sugiura Reiko
Genes to cells 20(4), 310-323, 2015-04
Pmk1, a fission yeast homologue of mammalian ERK MAPK, regulates cell wall integrity, cytokinesis, RNA granule formation and ion homeostasis. Our screen for vic (viable in the presence of immunosuppre …
NAID 120005608185

Irciniastatin A Induces Potent and Sustained Activation of Extracellular Signal-Regulated Kinase and Thereby Promotes Ectodomain Shedding of Tumor Necrosis Factor Receptor 1 in Human Lung Carcinoma A549 Cells

Quach Hue Tu,Hirano Seiya,Fukuhara Sayuri [他],Watanabe Tsubasa,Kanoh Naoki,Iwabuchi Yoshiharu,Usui Takeo,Kataoka Takao
Biological and Pharmaceutical Bulletin 38(6), 941-946, 2015
… In human lung carcinoma A549 cells, irciniastatin A induced a marked and sustained activation of extracellular signal-regulated kinase (ERK) and induced little activation of p38 mitogen-activated protein (MAP) kinase and c-Jun N-terminal kinase (JNK). …
NAID 130005072659