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the 9th letter of the Roman alphabet (同)i

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〈U〉〈C〉(…の)(量・額などの)不足,欠乏《+『of』(『in』)+『名』》 / 〈C〉不足分,不足量,不足額 / 〈C〉(精神・肉体などの)欠陥
『私は』私が
iodineの化学記号

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/03/28 01:31:39」(JST)

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IgG deficiency (Selective deficiency of immunoglobulin G) is a form of dysgammaglobulinemia where the proportional levels of the IgG isotype are reduced relative to other immunoglobulin isotypes. IgG deficiency is often found in children as transient hypogammaglobulinemia of infancy (THI), which may occur with or without additional decreases in IgA or IgM.

IgG has four subclasses: IgG₁, IgG₂, IgG₃, and IgG₄. It is possible to have either a global IgG deficiency, or a deficiency of one or more specific subclasses of IgG.^[1]^[2] The main clinically relevant form of IgG deficiency is IgG₂. IgG₃ deficiency is not usually encountered without other concomitant immunoglobulin deficiencies, and IgG₄ deficiency is very common but usually asymptomatic.^[3]

IgG1 is present in the bloodstream at a percentage of about 60-70%, IgG2-20-30%, IgG3 about 5-8 %, and IgG4 1-3 %. IgG subclass deficiencies affect only IgG subclasses (usually IgG2 or IgG3), with normal total IgG and IgM immunoglobulins and other components of the immune system being at normal levels. These deficiencies can affect only one subclass or involve an association of two subclasses, such as IgG2 and IgG4. IgG deficiencies are usually not diagnosed until the age of 10. Some of the IgG levels in the blood are undetectable and have a low percentage such as IgG4, which makes it hard to dertermine if a deficiency is actually present. IgG subclass deficiencies are sometimes correlated with bad responses to pneumoccal polyscaccharides, especially IgG2 and or IgG4 deficiency. Some of these deficiencies are also involved with pancreatitis and have been linked to IgG4 levels.

References

^ Barton JC, Bertoli LF, Acton RT (June 2003). "HLA-A and -B alleles and haplotypes in 240 index patients with common variable immunodeficiency and selective IgG subclass deficiency in central Alabama". BMC Med. Genet. 4: 3. doi:10.1186/1471-2350-4-3. PMC 166147. PMID 12803653.
^ Dhooge IJ, van Kempen MJ, Sanders LA, Rijkers GT (June 2002). "Deficient IgA and IgG2 anti-pneumococcal antibody levels and response to vaccination in otitis prone children". Int. J. Pediatr. Otorhinolaryngol. 64 (2): 133–41. doi:10.1016/S0165-5876(02)00068-X. PMID 12049826.
^ Driessen, G; van der Burg, M (June 2011). "Educational paper: primary antibody deficiencies.". European journal of pediatrics 170 (6): 693–702. doi:10.1007/s00431-011-1474-x. PMID 21544519.

"IgG Subclass Deficiency." Immune Deficiency Foundation. Web. 1 May 2015. <http://primaryimmune.org/about-primary-immunodeficiencies/specific-disease-types/igg-subclass-deficiency/>.

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1. IgG サブクラス欠乏症 igg subclass deficiency
2. 原発性の体液性免疫不全：概要 primary humoral immune deficiencies an overview
3. IgGサブクラス：物理学的性質、遺伝的特徴、および生物学的機能 igg subclasses physical properties genetics and biologic functions
4. 原発性免疫不全症における免疫グロブリン療法 immune globulin therapy in primary immunodeficiency
5. 特異的抗体欠損 specific antibody deficiency

English Journal

Retinal vasculitis revealing immunoglobulin g subclass deficiency.

Tahiri Joutei Hassani R, Rousseau A, de Monchy I, El Sanharawi M, Gendron G, Barreau E, Goujard C, Labetoulle M.SourceDepartment of Ophthalmology, Bicêtre University Hospital , AP-HP, University Paris-Sud 11, Le Kremlin Bicêtre , France.
Ocular immunology and inflammation.Ocul Immunol Inflamm.2013 Feb;21(1):67-9. doi: 10.3109/09273948.2012.734537.
Immunoglobulin G (IgG) subclass deficiency is a rare primary immunodeficiency syndrome characterized by recurrent infections and autoimmune disorders. However, there have been no reports of ocular involvement, either inflammatory or infectious, in association with IgG subclass deficiency. The author
PMID 23323588

Systemic atopy and immunoglobulin deficiency in Turkish patients with vernal keratoconjunctivitis.

Bozkurt B, Artac H, Arslan N, Gokturk B, Bozkurt MK, Reisli I, Irkec M.SourceSelcuk University, Selcuk University Faculty of Medicine, Department of Ophthalmology , Konya , Turkey.
Ocular immunology and inflammation.Ocul Immunol Inflamm.2013 Feb;21(1):21-6. doi: 10.3109/09273948.2012.723110.
Purpose: To determine the prevalence of systemic atopy and immunoglobulin (Ig) deficiencies in vernal keratoconjunctivitis (VKC). Methods: Sixty-seven VKC subjects (79.1% boys) with a mean age of 11.3 ± 4.3 years were included. Serum Ig levels and specific IgE levels were measured using the n
PMID 23323578

Japanese Journal

Common variable immune deficiency in a Pomeranian with Pneumocystis carinii pneumonia

, , , , , , ,
Journal of Veterinary Medical Science advpub(0), 2015
… Serum immunoglobulin concentrations of IgG and IgA were low. … B-cell hypoplasia with subsequent antibody deficiency was suspected. …
NAID 130004781093

The involvement of CD36 in monocyte activation by antiphospholipid antibodies

Kato M.,Atsumi T.,Oku K.,Amengual O.,Nakagawa H.,Fujieda Y.,Otomo K.,Horita T.,Yasuda S.,Koike T.
Lupus 22(8), 761-771, 2013-07
… Methods First, rs3765187, a missense mutation linked to CD36 deficiency, was investigated by TaqMan polymerase chain reaction (PCR) genotyping method in 819 Japanese, including 132 patients with APS, 265 with systemic lupus erythematosus (SLE) in the absence of APS, and 422 healthy subjects. … Purified IgG from patients with APS and a monoclonal phosphatidylserine-dependent antiprothrombin antibody were used in these experiments. …
NAID 120005372328

Fas deficiency in mice with the Balb/c background induces blepharitis with allergic inflammation and hyper-IgE production in conjunction with severe autoimmune disease.

Takahashi Suzuka,Futatsugi-Yumikura Shizue,Fukuoka Ayumi,Yoshimoto Tomohiro,Nakanishi Kenji,Yonehara Shin
International immunology 25(5), 287-293, 2013-05
… To our astonishment, Balb/c Fas KO mice spontaneously develop blepharitis with not only autoimmune inflammation with deposition of auto-antibody but also allergic inflammation with infiltration by eosinophils and mast cells and show the capacity to strongly increase serum level of IgE and IgG1 along with their aging. …
NAID 120005474478

「IgG欠乏」

IgG deficiency
	Immunoglobulin G
Classification and external resources
Specialty	hematology
ICD-10	D80.3
ICD-9-CM	279.03
eMedicine	med/1161
MeSH	D017099
	[edit on Wikidata]