IRF-7

• インターフェロン調節因子-7

関

interferon regulatory factor-7

WordNet

1. the 9th letter of the Roman alphabet (同)i

PrepTutorEJDIC

1. 『私は』私が
2. iodineの化学記号

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2013/03/10 00:18:16」(JST)

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Interferon regulatory factor 7
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 2O61
Identifiers
Symbols	IRF7; IRF-7H; IRF7A
External IDs	OMIM: 605047 MGI: 1859212 HomoloGene: 128624 GeneCards: IRF7 Gene
Gene Ontology Molecular function • RNA polymerase II core promoter sequence-specific DNA binding • RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity • DNA binding • protein binding Cellular component • nucleus • nucleoplasm • cytoplasm • cytosol • endosome membrane Biological process • negative regulation of transcription from RNA polymerase II promoter • MyD88-independent toll-like receptor signaling pathway • regulation of adaptive immune response • transcription from RNA polymerase II promoter • protein phosphorylation • protein acetylation • response to DNA damage stimulus • Toll signaling pathway • response to virus • immunoglobulin mediated immune response • establishment of viral latency • cytokine-mediated signaling pathway • regulation of type I interferon production • interferon-alpha production • interferon-beta production • positive regulation of interferon-alpha production • positive regulation of interferon-beta production • regulation of MyD88-dependent toll-like receptor signaling pathway • regulation of MyD88-independent toll-like receptor signaling pathway • toll-like receptor 3 signaling pathway • toll-like receptor 4 signaling pathway • TRIF-dependent toll-like receptor signaling pathway • MDA-5 signaling pathway • innate immune response • type I interferon biosynthetic process • regulation of monocyte differentiation • positive regulation of transcription, DNA-dependent • positive regulation of transcription from RNA polymerase II promoter • regulation of immune response • interferon-gamma-mediated signaling pathway • type I interferon-mediated signaling pathway • negative regulation of macrophage apoptotic process Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	3665	54123
Ensembl	ENSG00000185507	ENSMUSG00000025498
UniProt	Q92985	P70434
RefSeq (mRNA)	NM_001572	NM_001252600
RefSeq (protein)	NP_001563	NP_001239529
Location (UCSC)	Chr 11: 0.61 – 0.62 Mb	Chr 7: 141.26 – 141.27 Mb
PubMed search	[1]	[2]

Interferon regulatory factor 7, also known as IRF7, is a member of the interferon regulatory factor family of transcription factors.

IRF7 encodes interferon regulatory factor 7, a member of the interferon regulatory transcription factor (IRF) family. IRF7 has been shown to play a role in the transcriptional activation of virus-inducible cellular genes, including the type I interferon genes. In particular, IRF7 regulates many interferon-alpha genes. Constitutive expression of IRF7 is largely restricted to lymphoid tissue, largely plasmacytoid dendritic cells, whereas IRF7 is inducible in many tissues. Multiple IRF7 transcript variants have been identified, although the functional consequences of these have not yet been established.

The IRF7 pathway was shown to be silenced in some metastatic breast cancer cell lines, which may help the cells avoid the host immune response. Restoring IRF7 to these cell lines reduced metastases and increased host survival time in animal models.

See also

• Interferon regulatory factors

Interactions

IRF7 has been shown to interact with IRF3.

References

Further reading

Ning S*, Pagano J, Barber G. IRF7: activation, regulation, modification, and function. (Review). Genes & Immunity. 2011. Epub ahead of print: 4/14/2011 PMID 21490621

• Pitha PM, Au WC, Lowther W et al. (1999). "Role of the interferon regulatory factors (IRFs) in virus-mediated signaling and regulation of cell growth". Biochimie 80 (8–9): 651–8. doi:10.1016/S0300-9084(99)80018-2. PMID 9865487.
• Zhang L, Pagano JS (2002). "Structure and function of IRF-7". J. Interferon Cytokine Res. 22 (1): 95–101. doi:10.1089/107999002753452700. PMID 11846980.
• Zhang L, Pagano JS (1997). "IRF-7, a new interferon regulatory factor associated with Epstein-Barr virus latency". Mol. Cell. Biol. 17 (10): 5748–57. PMC 232423. PMID 9315633. //www.ncbi.nlm.nih.gov/pmc/articles/PMC232423/.
• Wathelet MG, Lin CH, Parekh BS et al. (1998). "Virus infection induces the assembly of coordinately activated transcription factors on the IFN-beta enhancer in vivo". Mol. Cell 1 (4): 507–18. doi:10.1016/S1097-2765(00)80051-9. PMID 9660935.
• Au WC, Moore PA, LaFleur DW et al. (1998). "Characterization of the interferon regulatory factor-7 and its potential role in the transcription activation of interferon A genes". J. Biol. Chem. 273 (44): 29210–7. doi:10.1074/jbc.273.44.29210. PMID 9786932.
• Lu R, Au WC, Yeow WS et al. (2000). "Regulation of the promoter activity of interferon regulatory factor-7 gene. Activation by interferon snd silencing by hypermethylation". J. Biol. Chem. 275 (41): 31805–12. doi:10.1074/jbc.M005288200. PMID 10924517.
• Paris MJ, Williams BR (2001). "Characterization of a 500-kb contig spanning the region between c-Ha-Ras and MUC2 on chromosome 11p15.5". Genomics 69 (2): 196–202. doi:10.1006/geno.2000.6339. PMID 11031102.
• Marié I, Smith E, Prakash A, Levy DE (2000). "Phosphorylation-Induced Dimerization of Interferon Regulatory Factor 7 Unmasks DNA Binding and a Bipartite Transactivation Domain". Mol. Cell. Biol. 20 (23): 8803–14. doi:10.1128/MCB.20.23.8803-8814.2000. PMC 86519. PMID 11073981. //www.ncbi.nlm.nih.gov/pmc/articles/PMC86519/.
• Smith EJ, Marié I, Prakash A et al. (2001). "IRF3 and IRF7 phosphorylation in virus-infected cells does not require double-stranded RNA-dependent protein kinase R or Ikappa B kinase but is blocked by Vaccinia virus E3L protein". J. Biol. Chem. 276 (12): 8951–7. doi:10.1074/jbc.M008717200. PMID 11124948.
• Au WC, Yeow WS, Pitha PM (2001). "Analysis of functional domains of interferon regulatory factor 7 and its association with IRF-3". Virology 280 (2): 273–82. doi:10.1006/viro.2000.0782. PMID 11162841.
• Lu R, Moore PA, Pitha PM (2002). "Stimulation of IRF-7 gene expression by tumor necrosis factor alpha: requirement for NFkappa B transcription factor and gene accessibility". J. Biol. Chem. 277 (19): 16592–8. doi:10.1074/jbc.M111440200. PMID 11877397.
• Morin P, Bragança J, Bandu MT et al. (2002). "Preferential binding sites for interferon regulatory factors 3 and 7 involved in interferon-A gene transcription". J. Mol. Biol. 316 (5): 1009–22. doi:10.1006/jmbi.2001.5401. PMID 11884139.
• Caillaud A, Prakash A, Smith E et al. (2003). "Acetylation of interferon regulatory factor-7 by p300/CREB-binding protein (CBP)-associated factor (PCAF) impairs its DNA binding". J. Biol. Chem. 277 (51): 49417–21. doi:10.1074/jbc.M207484200. PMID 12374802.
• Izmailova E, Bertley FM, Huang Q et al. (2003). "HIV-1 Tat reprograms immature dendritic cells to express chemoattractants for activated T cells and macrophages". Nat. Med. 9 (2): 191–7. doi:10.1038/nm822. PMID 12539042.
• Yang H, Lin CH, Ma G et al. (2003). "Interferon regulatory factor-7 synergizes with other transcription factors through multiple interactions with p300/CBP coactivators". J. Biol. Chem. 278 (18): 15495–504. doi:10.1074/jbc.M212940200. PMID 12604599.
• Ning S, Hahn AM, Huye LE, Pagano JS (2003). "Interferon Regulatory Factor 7 Regulates Expression of Epstein-Barr Virus Latent Membrane Protein 1: a Regulatory Circuit". J. Virol. 77 (17): 9359–68. doi:10.1128/JVI.77.17.9359-9368.2003. PMC 187426. PMID 12915551. //www.ncbi.nlm.nih.gov/pmc/articles/PMC187426/.
• Fitzgerald KA, Rowe DC, Barnes BJ et al. (2003). "LPS-TLR4 Signaling to IRF-3/7 and NF-κB Involves the Toll Adapters TRAM and TRIF". J. Exp. Med. 198 (7): 1043–55. doi:10.1084/jem.20031023. PMC 2194210. PMID 14517278. //www.ncbi.nlm.nih.gov/pmc/articles/PMC2194210/.
• Lin R, Noyce RS, Collins SE et al. (2004). "The Herpes Simplex Virus ICP0 RING Finger Domain Inhibits IRF3- and IRF7-Mediated Activation of Interferon-Stimulated Genes". J. Virol. 78 (4): 1675–84. doi:10.1128/JVI.78.4.1675-1684.2004. PMC 369457. PMID 14747533. //www.ncbi.nlm.nih.gov/pmc/articles/PMC369457/.

External links

• IRF7+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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English Journal

• Bcl6 Sets a Threshold for Antiviral Signaling by Restraining IRF7 Transcriptional Program.

• Xu F1, Kang Y2, Zhuang N2, Lu Z2, Zhang H2, Xu D2,3, Ding Y2, Yin H2, Shi L2,4.
• Scientific reports.Sci Rep.2016 Jan 5;6:18778. doi: 10.1038/srep18778.
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• PMID 26728228

• Depletion of elongation initiation factor 4E binding proteins by CRISPR/Cas9 enhances the antiviral response in porcine cells.

• Ramírez-Carvajal L1, Singh N2, de Los Santos T3, Rodríguez LL3, Long CR2.
• Antiviral research.Antiviral Res.2016 Jan;125:8-13. doi: 10.1016/j.antiviral.2015.11.002. Epub 2015 Nov 22.
• Type I interferons (IFNs) are key mediators of the innate antiviral response in mammalian cells. Elongation initiation factor 4E binding proteins (4E-BPs) are translational controllers of interferon regulatory factor 7 (IRF-7), the "master regulator" of IFN transcription. Previous studies have sugge
• PMID 26592975

• Genetic characterization of bovine viral diarrhea virus strains in Beijing, China and innate immune responses of peripheral blood mononuclear cells in persistently infected dairy cattle.

• Weng XG1, Song QJ1, Wu Q1, Liu MC1, Wang ML1, Wang JF1.
• Journal of veterinary science.J Vet Sci.2015 Dec 30;16(4):491-500. doi: 10.4142/jvs.2015.16.4.491.
• To acquire epidemiological data on the bovine viral diarrhea virus (BVDV) and identify cattle persistently infected (PI) with this virus, 4,327 samples from Holstein dairy cows were screened over a four-year period in Beijing, China. Eighteen BVD viruses were isolated, 12 from PI cattle. Based on ge
• PMID 26119170

Japanese Journal

• Identification of a polyI:C-inducible membrane protein that participates in dendritic cell-mediated natural killer cell activation

• Ebihara Takashi,Azuma Masahiro,Oshiumi Hiroyuki,Kasamatsu Jun,Iwabuchi Kazuya,Matsumoto Kenji,Saito Hirohisa,Taniguchi Tadatsugu,Matsumoto Misako,Seya Tsukasa
• Journal of Experimental Medicine 207(12), 2675-2687, 2010-11-08
• … TICAM-1 signals culminate in interferon (IFN) regulatory factor (IRF) 3 activation. … The protein, referred to as IRF-3-dependent NK-activating molecule (INAM), functioned in both the mDC and NK cell to facilitate NK activation. … In the mDC, TICAM-1, IFN promoter stimulator 1, and IRF-3, but not IRF-7, were required for mDC-mediated NK activation. …
• NAID 120002722561

• Phylogenetic and expression analysis of lamprey toll-like receptors

• Kasamatsu Jun,Oshiumi Hiroyuki,Matsumoto Misako,Kasahara Masanori,Seya Tsukasa
• Developmental & Comparative Immunology 34(8), 855-865, 2010-08
• … In addition, type I interferon (IFN), interferon regulatory factor (IRF)-3, and IRF7 were not identified in the lamprey genome although TLR adaptor and signal transduction genes were highly conserved upstream of (IRF)-3/7 and type I IFN in most vertebrates. …
• NAID 120002261717

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★リンクテーブル★

リンク元	「interferon regulatory factor-7」「インターフェロン調節因子-7」
関連記事	「I」「IRF」「IR」

「interferon regulatory factor-7」

　　[★] インターフェロン調節因子-7

関

IRF-7

「インターフェロン調節因子-7」

　　[★]

英

interferon regulatory factor-7、IRF-7

「I」

　　[★]

• イソロイシン isoleucine
• イノシン inosine
• 阻害剤 inhibitor
• iodine
• ヨード iodide
• I因子 factor I

　 　 　

「IRF」

　　[★]

• インターフェロン調節因子

関

interferon regulatory factor

「IR」

　　[★]

• 反転回復 inversion recovery