WordNet
- having partial rights and privileges or subordinate status; "an associate member"; "an associate professor"
- a person who joins with others in some activity or endeavor; "he had to consult his associate before continuing"
- a person with subordinate membership in a society, institution, or commercial enterprise; "associates in the law firm bill at a lower rate than do partners"
- any event that usually accompanies or is closely connected with another; "first was the lightning and then its thunderous associate"
- make a logical or causal connection; "I cannot connect these two pieces of evidence in my mind"; "colligate these facts"; "I cannot relate these events at all" (同)tie_in, relate, link, colligate, link up, connect
- the time when something ends; "it was the death of all his plans"; "a dying of old hopes" (同)dying, demise
- the time at which life ends; continuing until dead; "she stayed until his death"; "a struggle to the last" (同)last
- the absence of life or state of being dead; "he seemed more content in death than he had ever been in life"
- the permanent end of all life functions in an organism or part of an organism; "the animal died a painful death"
- the act of killing; "he had two deaths on his conscience"
- the event of dying or departure from life; "her death came as a terrible shock"; "upon your decease the capital will pass to your grandchildren" (同)decease, expiry
- territory over which rule or control is exercised; "his domain extended into Europe"; "he made it the law of the land" (同)demesne, land
- (mathematics) the set of values of the independent variable for which a function is defined (同)domain of a function
- any of a large group of nitrogenous organic compounds that are essential constituents of living cells; consist of polymers of amino acids; essential in the diet of animals for growth and for repair of tissues; can be obtained from meat and eggs and milk and legumes; "a diet high in protein"
PrepTutorEJDIC
- 〈人〉'を'(…の)『仲間に加える』,(…に)連合させる《+『名』〈人〉+『with』+『名』》 / (…と)…'を'結びつけて考える(起こす)《+『名』+『with』+『名』》 / (…と)『仲間になる』,交際する《+『with』+『名』》 / (…と)合体する,提携する《+『with』+『名』》 / 『仲間』,『同僚』;組合員 / 準会員 / 付属物;連想されるもの / 連合した;仲間の,同僚の / 補助の,準…
- 〈U〉〈C〉『死』,死亡;死に方,死にざま / 〈U〉死んだ[ような]状体 / 《the~》(…の)絶滅,破滅《+『of』+『名』》 / 《the~》(…の)死の原因,命取り《+『of』+『名』》 / 《通例『D-』》死神(手に鎌(かマ)を持った黒装束の骸骨(がいこつ)で表される)
- (国の)領地,領土;(個人の)所有地 / (関心・活動などの)範囲,分野 / (個人・一族の)所有地 / (数学で)変域(関数の独立変数がとる値の集合)
- 蛋白(たんばく)質
UpToDate Contents
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- 1. BおよびTリンパ球の正常な発生 normal b and t lymphocyte development
- 2. アポトーシスと自己免疫疾患 apoptosis and autoimmune disease
- 3. 自己免疫性リンパ増殖症候群(ALPS)：疫学および病因 autoimmune lymphoproliferative syndrome alps epidemiology and pathogenesis
- 4. 適応細胞性免疫応答 the adaptive cellular immune response
- 5. 自然免疫系の概要 an overview of the innate immune system
English Journal
- The Drosophila IMD pathway in the activation of the humoral immune response.
- Kleino A, Silverman N.SourceDivision of Infectious Diseases, Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA. Electronic address: anni.kleino@umassmed.edu.
- Developmental and comparative immunology.Dev Comp Immunol.2014 Jan;42(1):25-35. doi: 10.1016/j.dci.2013.05.014. Epub 2013 May 27.
- The IMD pathway signaling plays a pivotal role in the Drosophila defense against bacteria. During the last two decades, significant progress has been made in identifying the components and deciphering the molecular mechanisms underlying this pathway, including the means of bacterial sensing and sign
- PMID 23721820
- Regulation of the MIR155 host gene in physiological and pathological processes.
- Elton TS, Selemon H, Elton SM, Parinandi NL.SourceDavis Heart and Lung Research Institute, The Ohio State University, Columbus, OH, USA; College of Pharmacy, Division of Pharmacology, The Ohio State University, Columbus, OH, USA; Department of Medicine, Division of Cardiology, The Ohio State University, Columbus, OH, USA. Electronic address: terry.elton@osumc.edu.
- Gene.Gene.2013 Dec 10;532(1):1-12. doi: 10.1016/j.gene.2012.12.009. Epub 2012 Dec 14.
- MicroRNAs (miRNAs), a family of small nonprotein-coding RNAs, play a critical role in posttranscriptional gene regulation by acting as adaptors for the miRNA-induced silencing complex to inhibit gene expression by targeting mRNAs for translational repression and/or cleavage. miR-155-5p and miR-155-3
- PMID 23246696
- Phytoestrogens induce apoptosis through a mitochondria/caspase-pathway in human breast cancer cells.
- Chen FP, Chien MH.AbstractAbstract Objective: To explore the effect and pathway of phytoestrogens on the growth of breast cancer cell line MCF-7. Methods: MCF-7 cells (human estrogen -receptor-positive and progesterone-receptor-positive breast cancer cells) were cultured in serum-free medium for 24 h and then treated with genistein, resveratrol, and quercetin (10-10 to 10-4 M). After further incubation for 24, 48, 72, and 92 h, the cells were harvested and extracted for MTT assay. According to the above results, the proteins involving proliferative and apoptotic pathway were evaluated by western blot analysis. Results: Genistein, resveratrol, and quercetin significantly inhibited cellular proliferation in a dose- and time-dependent manner. Significantly elevated caspase-3 activity was noted after treatment with genistein (10-9-10-7 M), as well as with resveratrol and quercetin (10-9-10-5 M). Significant reduction of PI3K and Akt protein and significant increase of Fas ligand, Fas-Associated protein with Death Domain, cytochrome C, truncated Bid, caspase-9, and caspase-3 were all noted after genistein, resveratrol, and quercetin treatment. E2 induced completely opposite results. ER α expression was significantly increased in E2, whereas ER β expression was significantly elevated in the cultures with genistein, resveratrol, and quercetin. Conclusions: These data demonstrate that genistein, resveratrol, and quercetin have anti-proliferative effects on breast cancer cells. They inducing apoptosis involves the activation of both the intrinsic and extrinsic apoptotic pathways, which may be related to the differential affinity to ER α and ER β. Whether phytoestrogens have similar effects on normal breast cells remains to be examined.
- Climacteric : the journal of the International Menopause Society.Climacteric.2013 Dec 4. [Epub ahead of print]
- Abstract Objective: To explore the effect and pathway of phytoestrogens on the growth of breast cancer cell line MCF-7. Methods: MCF-7 cells (human estrogen -receptor-positive and progesterone-receptor-positive breast cancer cells) were cultured in serum-free medium for 24 h and then treated with ge
- PMID 24299158
Japanese Journal
- Induction of Apoptosis by Icariside II through Extrinsic and Intrinsic Signaling Pathways in Human Breast Cancer MCF7 Cells
- HUANG Chaoqing,CHEN Xiaoguang,GUO Baolin [他],HUANG Wenhua,SHEN Ting,SUN Xinguang,XIAO Peigen,ZHOU Qing
- Bioscience, Biotechnology, and Biochemistry 76(7), 1322-1328, 2012
- … In contrast, IcaS enhanced the expression level of Fas and the Fas-associated death domain (FADD), and activated caspase-8, suggesting the involvement of the extrinsic apoptosis pathway. … IcaS also increased the expression of Bax and BimL without affecting the expression status of Bcl-2 and Bid, suggesting that the apoptosis induced by IcaS was related to Bcl-2 family protein regulation. …
- NAID 130001862722
- DIC診療における現状の問題点と今後の展望 (特集 変貌するDICの診断と治療) -- (臨床編)
- 松田 直之
- Thrombosis medicine 1(1), 73-76, 2011-08-00
- NAID 40019352591
- The Protective Effect of Silibinin Against Mitomycin C-Induced Intrinsic Apoptosis in Human Melanoma A375-S2 Cells
- Jiang Yuan-yuan,Wang Hong-jun,Wang Jing [他],TASHIRO Shin-ichi,ONODERA Satoshi,IKEJIMA Takashi
- Journal of pharmacological sciences 111(2), 137-146, 2009-10-20
- … We found that silibinin exhibited a protective effect against chemotherapeutic reagent mitomycin C–induced cell death in A375-S2 cells in a p53-dependent manner, which contradicted the findings of previous studies investigating the anti-neoplastic activity of silibinin and developing silibinin as a potential anti-neoplastic drug in clinical therapy. … Mitomycin C administration triggered a time- and dose-dependent cell death in A375-S2 cells. …
- NAID 10025738980
Related Links
- Can self-associate. Interacts with CFLAR, PEA15 and MBD4. When phosphorylated, part of a complex containing HIPK3 and FAS. May interact with MAVS/IPS1. Interacts with MOCV v-CFLAR protein and PIDD1. Interacts (via death ...
- FADD » FAS-associated death domain favorite label Protein also known as: FAS-associating death domain-containing protein. Gene name: FADD Entry whose protein(s) existence is based on evidence at protein level 1 168 1 ...
Related Pictures
★リンクテーブル★
| リンク元 | 「FADD protein」「Fas結合デスドメインタンパク質」 |
| 関連記事 | 「associate」「FAS」「domain」「associated」「F」 |
「FADD protein」
「Fas結合デスドメインタンパク質」
「associate」
- vt.
- 結合する、連合させる。連想によって結びつける。(人を)仲間/友達などとしての関係に置く。(化)会合させる
- vi.
- 仲間/友人などとして交際する(with)。一つにまとめる、連合する
- n.
- 仕事仲間、提携者、同僚。友人、朋友。準会員。従業員、社員
- 密接な蒸す偽付きのある物、付随する物、つきもの。準国家
- 連想によって心に浮かぶ言葉/思い、連想物
- adj.
- 仲間の、同僚の。製紙機械員に次ぐ資格の
- 付随する、連想される
- 関
- accompany、association、associative、attach、bearing、bind、binding、bond、bonding、coassemble、colleague、combine、conjoin、conjugate、conjugation、conjunction、connect、connection、correlate、correlation、couple、dock、engage、engagement、federation、implication、join、joint、ligate、link、linkage、peer、pertinent、reference、relate、relation、relationship、relative、relevance、relevant、symphysial、union
「FAS」
- 胎児性アルコール症候群 fetal alcohol syndrome
- 脂肪酸合成酵素 fatty acid synthetase：fatty acid synthetase 1、fatty acid synthetase 2
- (アポトーシスに関連)CD95 Fas
「domain」
- n.
「associated」
- adj.
- 随伴の、随伴性の